Ellipticine (hydrochloride)
- Product Name
- Ellipticine (hydrochloride)
- CAS No.
- 5081-48-1
- Chemical Name
- Ellipticine (hydrochloride)
- Synonyms
- NSC 71795 (hydrochloride);Ellipticine hydrochloride, 10 mM in DMSO;Ellipticine hydrochloride(NSC 71795 hydrochloride);5,11-dimethyl-6H-pyrido[4,3-b]carbazole hydrogen chloride;Inhibitor,Ellipticine hydrochloride,Ellipticine,NSC71795,NSC 71795,NSC-71795,Topoisomerase,inhibit
- CBNumber
- CB43167610
- Molecular Formula
- C17H15ClN2
- Formula Weight
- 282.77
- MOL File
- 5081-48-1.mol
Ellipticine (hydrochloride) Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO:4.4(Max Conc. mg/mL);15.56(Max Conc. mM)
- form
- A crystalline solid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 18742
- Product name
- Ellipticine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5 mg
- Price
- $65
- Updated
- 2024/03/01
- Product number
- 18742
- Product name
- Ellipticine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10 mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- 18742
- Product name
- Ellipticine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25 mg
- Price
- $223
- Updated
- 2024/03/01
- Product number
- 18742
- Product name
- Ellipticine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 50 mg
- Price
- $380
- Updated
- 2024/03/01
- Product number
- CS-6199
- Product name
- Ellipticinehydrochloride
- Purity
- 99.34%
- Packaging
- 50mg
- Price
- $372
- Updated
- 2021/12/16
Ellipticine (hydrochloride) Chemical Properties,Usage,Production
Uses
Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
in vivo
Ellipticine (NSC 71795) treatment results in ellipticine-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b5 protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b5 may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795)[3].
IC 50
Topoisomerase II
References
[1] Stiborova M, et al. Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):13-23. DOI:10.5507/bp.2006.002
[2] Stiborova M, et al. Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip Toxicol. 2011 Jun;4(2):98-105. DOI:10.2478/v10102-011-0017-7
[3] Stiborova M, et al. The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN?) mice and pure enzymes. Int J Mol Sci. 2014 Dec 25;16(1):284-306. DOI:10.3390/ijms16010284
Ellipticine (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
Ellipticine (hydrochloride) Suppliers
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- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
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