ChemicalBook > CAS DataBase List > PROFOXYDIM-LITHIUM

PROFOXYDIM-LITHIUM

Product Name
PROFOXYDIM-LITHIUM
CAS No.
139001-49-3
Chemical Name
PROFOXYDIM-LITHIUM
Synonyms
AIK;AURA;STK7;BTAK;STK6;ARK1;AIRK1;AURKA;STK15;TETRIS
CBNumber
CB4320465
Molecular Formula
C24H32ClNO4S
Formula Weight
466.03
MOL File
139001-49-3.mol
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PROFOXYDIM-LITHIUM Property

Melting point:
<25 °C
Boiling point:
597.2±60.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
-70°C
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
pka
4.25±0.25(Predicted)
color 
White to Off-White
Stability:
Hygroscopic, Unstable in Solution
EPA Substance Registry System
Profoxydim (139001-49-3)
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Safety

Hazard Codes 
Xn
Risk Statements 
21/22
Safety Statements 
36/37
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SRP5034
Product name
GRK2, active, GST tagged human
Purity
PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Packaging
10μG
Price
$520
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
CHM0290689
Product name
PROFOXYDIM-LITHIUM
Purity
98.00%
Packaging
1G
Price
$1238.16
Updated
2021/12/16
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PROFOXYDIM-LITHIUM Chemical Properties,Usage,Production

Uses

Profoxydim Lithium Salt is a salt of Profoxydim (139001-49-3) and an herbicide.

Definition

ChEBI: Profoxydim is a cyclic ketone that is 3-hydroxycyclohex-2-en-1-one substituted by a N-[2-(4-chlorophenoxy)propoxy]butanimidoyl group at position 2 and by a thian-3-yl group at position 5. It is a herbicide used for the control of grass weeds in rice. It has a role as a herbicide and an EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor. It is an oxime O-ether, a member of monochlorobenzenes, an aromatic ether, an enol, an organosulfur heterocyclic compound and a cyclic ketone.

General Description

G-protein-coupled receptor kinase 2 (GRK2), which is officially known as adrenergic, beta, receptor kinase 1 (ADRBK1), gene codes for a 689 amino acid protein, that is of 79.573kDa. This gene has 12 catalytic region subdomains. GRK2 is expressed in the vascular endothelium, arterial smooth muscle, myocardium, kidney and in the renal proximal tubule. It is mapped to human chromosome 11q13.

Biochem/physiol Actions

G-protein-coupled receptor kinase 2 (GRK2) or ADRBK1 is a ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G protein-coupled receptors. GRK2 phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. RAF kinase inhibitor protein RKIP is a physiologic inhibitor of GRK2. After stimulation of G protein-coupled receptors, RKIP dissociates from its known target, RAF1 to associate with GRK2 and block its activity. G-protein-coupled receptor kinase 2 (GRK2) controls several intracellular mechanisms. It helps to maintain the structure and activities of the heart. Hence it participates in several cardiovascular diseases. GRK2 also modulates ion and fluid transport and eventually, blood pressure. It increases the synthesis of mitochondrial superoxide and reduces oxygen utilization and ATP synthesis. This protein serves as a major onco-modulator.

PROFOXYDIM-LITHIUM Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PROFOXYDIM-LITHIUM manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Profoxydim-lithium 139001-49-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%+
Supply Ability
100 tons
Release date
2020-01-13
Career Henan Chemical Co
Product
PROFOXYDIM-LITHIUM 139001-49-3
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
10kg
Release date
2018-12-18

139001-49-3, PROFOXYDIM-LITHIUMRelated Search:


  • CLEFOXYDIM
  • (5RS)-2-{(EZ)-1-[(2RS)-2-(4-chlorophenoxy)propoxyimino]butyl}-3-hydroxy-5-[(3RS)-thian-3-yl]cyclohex-2-en-1-one
  • TETRIS
  • PROFOXYDIM
  • PROFOXYDIM-LITHIUM
  • PROFOXYDIM LITHIUM SALT
  • BAS625H
  • AURA
  • CLEFOXYDIM LITHIUM SALT
  • Aurora Kinase A active human
  • GRK2, active, GST tagged human
  • Anti-Aurora Kinase antibody produced in rabbit
  • ANTI-AIK(N-TERMINAL) antibody produced in rabbit
  • AURORA A, active, GST tagged from mouse
  • MGC34538
  • STK7
  • BTAK
  • Monoclonal Anti-AURKA antibody produced in mouse
  • STK6
  • AIK
  • AIRK1
  • ANTI-AURORA-A(C-TERMINAL) antibody produced in rabbit
  • ARK1
  • AURKA
  • Anti-AURA, C-Terminal antibody produced in rabbit
  • Aurora-A
  • Aurora-family kinase 1
  • Aurora-related kinase 1
  • AURORA A, active, GST tagged human
  • STK15
  • Anti-Serine/threonine protein kinase 15
  • AntiSTK15 (Serine/threonine protein kinase 15)
  • 2-Cyclohexen-1-one, 2-[1-[[2-(4-chlorophenoxy)propoxy]imino]butyl]-3-hydroxy-5-(tetrahydro-2H-thiopyran-3-yl)-
  • 139001-49-3
  • C24H31ClNO4SLi