1,3-Dimethyladamantane
- Product Name
- 1,3-Dimethyladamantane
- CAS No.
- 702-79-4
- Chemical Name
- 1,3-Dimethyladamantane
- Synonyms
- Dimethyladamantane;1,3-DIMETHYL ADAMANTINE;MeMantine Related CoMpound A;Memantine USP RC A;1,3-Dimethyladamanta;1, 3-dimethylfungane;3-Dimethyl Adamantane;Adamantane Impurity A;Memantine intermediate;1,5-Dimethyladamantane
- CBNumber
- CB4335302
- Molecular Formula
- C12H20
- Formula Weight
- 164.29
- MOL File
- 702-79-4.mol
1,3-Dimethyladamantane Property
- Melting point:
- -30 °C
- Boiling point:
- 201.5 °C
- Density
- 0.886 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.478(lit.)
- Flash point:
- 127 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- clear liquid
- Specific Gravity
- 0.886
- color
- Colorless to Almost colorless
- Stability:
- Stable. Incompatible with strong oxidizing agents. Flammable.
- InChI
- InChI=1S/C12H20/c1-11-4-9-3-10(5-11)7-12(2,6-9)8-11/h9-10H,3-8H2,1-2H3
- InChIKey
- CWNOIUTVJRWADX-UHFFFAOYSA-N
- SMILES
- C12(C)CC3CC(CC(C)(C3)C1)C2
- CAS DataBase Reference
- 702-79-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Adamantane, 1,3-dimethyl-(702-79-4)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
N-Bromosuccinimide Price
- Product number
- PHR2449
- Product name
- Memantine Related Compound A
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 100MG
- Price
- $683.05
- Updated
- 2025/07/31
- Product number
- 187836
- Product name
- 1,3-Dimethyladamantane
- Purity
- ≥99%
- Packaging
- 5g
- Price
- $148.2
- Updated
- 2025/07/31
- Product number
- 1380513
- Product name
- Memantine Related Compound A
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 50mg
- Price
- $1300
- Updated
- 2025/07/31
- Product number
- D1081
- Product name
- 1,3-Dimethyladamantane
- Purity
- >99.0%(GC)
- Packaging
- 5mL
- Price
- $54
- Updated
- 2025/07/31
- Product number
- D1081
- Product name
- 1,3-Dimethyladamantane
- Purity
- >99.0%(GC)
- Packaging
- 25mL
- Price
- $159
- Updated
- 2025/07/31
1,3-Dimethyladamantane Chemical Properties,Usage,Production
Chemical Properties
clear colourless liquid
Uses
1,3-Dimethyladamantane is a dimethylated adamantane derivative. Memantine impurity A. Memantine Related Compound A (1,3-Dimethyladamantane).
Application
1,3-Dimethyladamantane was used in the synthesis of 1,3-dibromo-5,7-dimethyladamantane.
Definition
ChEBI: 1,3-dimethyladamantane is a polycyclic alkane and a member of adamantanes. It derives from a hydride of an adamantane.
General Description
1,3-Dimethyladamantane undergoes C-H insertion reaction with phenylchlorocarbene. It reacts with with molecular oxygen in the presence of N-hydroxyphthalimide combined with cobalt salts to yield 3,5-dimethyladamantan-1-ol and 5,7-dimethyladamantane-1,3-diol.
Synthesis
941-37-7
702-79-4
GENERAL METHODS: A thiocarbonate solution was prepared by dissolving 5 g (107 mg, 0.200 mmol) of 1-bromo-3,5-dimethyladamantane in CPME (0.5 mL). Subsequently, a solution of n-Bu3SnH (75.7 mg, 0.260 mmol) and AIBN (6.6 mg, 0.040 mmol) in CPME (1.5 mL) was slowly added dropwise by syringe pump to the above thiocarbonate solution, and the reaction lasted for 30 min at 90 °C. After completion of the reaction, the mixture was continued to be stirred at the same temperature for 30 min, followed by concentration. The residue was purified by 10% w/w K2CO3-silica gel fast column chromatography using gradient elution (hexane → hexane/EtOAc = 100/1 → 50/1 → 20/1) to afford 6 g of cis-consistently cyclized product (53.6 mg, 0.140 mmol, 70% yield) and a mixture of cis- and trans-consistently diastereoisomers (22.0 mg. 0.0572 mmol, 29% yield, cis-trans ratio of 2.8:1). For spectral analysis, these isomers were separated by repeated column chromatography.
References
[1] Tetrahedron, 2013, vol. 69, # 10, p. 2251 - 2259
[2] Organic Letters, 2008, vol. 10, # 4, p. 533 - 536
[3] Journal of Organic Chemistry, 1983, vol. 48, # 16, p. 2762 - 2765
1,3-Dimethyladamantane Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,3-Dimethyladamantane manufacturers
- Product
- 1,3-Dimethyladamantane 702-79-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-09-26
- Product
- 1,3-Dimethyladamantane 702-79-4
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99% hplc
- Supply Ability
- 500TONS
- Release date
- 2025-05-30
- Product
- 1,3-Dimethyladamantane 702-79-4
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100 tons
- Release date
- 2024-08-08