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1,3-Adamantanedicarboxylic acid

Product Name
1,3-Adamantanedicarboxylic acid
CAS No.
39269-10-8
Chemical Name
1,3-Adamantanedicarboxylic acid
Synonyms
ADAMANTANE-1,3-DICARBOXYLIC ACID;(1s,3s,5r,7r)-AdaMantane-1,3-dicarboxylic acid;AKOS BC-0656;1,3-DICARBOXYADAMANTANE;adamantane-1,3-dicarboxylate;1,3-ADAMANTANEDICARBOXYLIC ACID;1,3-Adamantanedicarboxylic Acid >1,3-Adamantanedicarboxylic acid 98%;Tricyclo[3.3.1.13,7]decane-1,3-dicarboxylic acid;tricyclo(3.3.1.1(sup3,7))decane-1,3-dicarboxylicacid
CBNumber
CB5316047
Molecular Formula
C12H16O4
Formula Weight
224.25
MOL File
39269-10-8.mol
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1,3-Adamantanedicarboxylic acid Property

Melting point:
276-278 °C (lit.)
Boiling point:
380.6±15.0 °C(Predicted)
Density 
1.461±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Sparingly), Methanol (Slightly, Heated)
form 
Solid
pka
4.24±0.40(Predicted)
color 
White to Off-White
CAS DataBase Reference
39269-10-8(CAS DataBase Reference)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
3
RTECS 
YD1994000
HS Code 
29172090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
340820
Product name
1,3-Adamantanedicarboxylic acid
Purity
98%
Packaging
1G
Price
$120
Updated
2023/01/07
TCI Chemical
Product number
A1358
Product name
1,3-Adamantanedicarboxylic Acid
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$73
Updated
2024/03/01
TCI Chemical
Product number
A1358
Product name
1,3-Adamantanedicarboxylic Acid
Purity
>97.0%(GC)(T)
Packaging
25g
Price
$246
Updated
2024/03/01
Alfa Aesar
Product number
H60081
Product name
Adamantane-1,3-dicarboxylic acid, 98%
Packaging
1g
Price
$53.65
Updated
2024/03/01
Alfa Aesar
Product number
H60081
Product name
Adamantane-1,3-dicarboxylic acid, 98%
Packaging
5g
Price
$211.65
Updated
2024/03/01
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1,3-Adamantanedicarboxylic acid Chemical Properties,Usage,Production

Uses

1,3-Adamantanedicarboxylic acid is a carboxylic acid derivative of adamantane. It is widely used in drug industry, polymer synthesis and fine chemicals as key intermediates. It is also used as antidepressants or antiparkinsonic drugs in clinical practice.

Preparation

1,3-Adamantanedicarboxylic acid was synthesized from 1-adamantane carboxylic acid by one-pot method. In this process, the ratio of mixed acid (nitric acid and sulfuric acid) have important effect on the yield, the role of sulfuric acid not only is solvent, but also can improve the oxidate ability of nitric acid.
Efficient Synthesis of 1,3-Adamantanedicarboxylic Acid and 1,3-Diaminoadamantane

Reaction: 1-Adamantane carboxylic acid (20 g), nitric acid (65 %, 20 mL) and sulfuric acid (98 %, 160 mL) were placed in a three-necked roundbottom flask fitted with an efficient magnetic stirrer and a thermometer. Cooled to 0 oC and held at 0 oC, anhydrous formic acid (80 %, 70 mL) was added dropwise in 5 h and reacted for 1 h. poured to crushed ice, filtered and then washed the precipitate several times with water to give a white solid. Then the white solid was dissolved in aqueous NaOH solution and the upper clear solution was separated and acidified by HCl to pH = 3. Filtered, washed with water, dried in vacuum, recrystallized from ethanol. White solid, yield 22.9 g (92 %). m.p.: 275- 276 oC
1H NMR (DMSO-d6, 400 MHz) δ: 1.616 (m, 2H), 1.691-1.727 (m, 4H), 1.759-1.791 (m, 4H), 1.850-1.882 (m, 2H), 2.059 (m, 1H), 12.062 (br, s, 2H, COOH); 13C NMR (100 MHz, DMSO-d6) δ 27.37 (C-5, C-7), 34.98 (C-6), 37.66 (C-4, C-8, C-9, C-10), 39.78 (C-2), 39.89 (C-2, C-3), 177.76 (COOH). IR (KBr, νmax, cm-1) : 2913, 2851, 2636, 1691, 1451, 1410, 1344, 1249, 1103, 1084, 952, 743, 670, 528; Anal. calcd for C12H16O4: C 64.29, H 7.14; found C 64.55, H 7.22.

Purification Methods

Dissolve the acid in aqueous NaOH, treat with charcoal, filter and acidify with dilute HCl. It crystallises from MeOH. [Stetter & Wulff Chem Ber 93 1366 1960, Beilstein 9 III 4066, 9 IV 2997.]

1,3-Adamantanedicarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-Adamantanedicarboxylic acid Suppliers

TIANJIN MINXIANG BIOMEDICAL INC.
Tel
022-59596766 13313219033 18222332696
Fax
86-22-88718329
Email
jinpeng@mxpharm.com
Country
China
ProdList
98
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58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
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INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
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Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
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Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
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Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
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61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2963
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View Lastest Price from 1,3-Adamantanedicarboxylic acid manufacturers

Shanghai Qyubiotech Co., Ltd.
Product
1,3-Adamantanedicarboxylic acid 39269-10-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
97%+
Supply Ability
10000kgs per Month
Release date
2023-04-19
Career Henan Chemical Co
Product
1,3-Adamantanedicarboxylic acid 39269-10-8
Price
US $1.00/kg
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-21

39269-10-8, 1,3-Adamantanedicarboxylic acidRelated Search:


  • adamantane-1,3-dicarboxylate
  • tricyclo(3.3.1.1(sup3,7))decane-1,3-dicarboxylicacid
  • ADAMANTANE-1,3-DICARBOXYLIC ACID
  • AKOS BC-0656
  • 1,3-ADAMANTANEDICARBOXYLIC ACID
  • 1,3-DICARBOXYADAMANTANE
  • Tricyclo[3.3.1.13,7]decane-1,3-dicarboxylic acid
  • (1s,3s,5r,7r)-AdaMantane-1,3-dicarboxylic acid
  • 1,3-AdaMantanedicarboxylic acid SynonyMs AdaMantane-1,3-dicarboxylic acid
  • 1,3-Adamantanedicarboxylic acid 98%
  • 1,3-Adamantanedicarboxylic Acid &gt
  • 39269-10-8
  • Adamantanes
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