ChemicalBook > CAS DataBase List > 5-NITROOXINDOLE

5-NITROOXINDOLE

Product Name
5-NITROOXINDOLE
CAS No.
20870-79-5
Chemical Name
5-NITROOXINDOLE
Synonyms
5-Nitroindolin-2-one;B71139;NSC 25199;NSC 99066;5-Nitrooxidole;5-NITROOXINDOLE;5-NITRO-2-OXINDOLE;5-Nitrooxindole 96%;5-Nitro-2-indolinone;5-nitro-1H-indol-2-ol
CBNumber
CB4341569
Molecular Formula
C8H6N2O3
Formula Weight
178.14
MOL File
20870-79-5.mol
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5-NITROOXINDOLE Property

Melting point:
233-236 °C
Boiling point:
411.4±45.0 °C(Predicted)
Density 
1.449±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
solid
pka
12.61±0.20(Predicted)
color 
Beige
CAS DataBase Reference
20870-79-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-43
Safety Statements 
26-36/37
WGK Germany 
3
Hazard Note 
Irritant/Keep Cold
HS Code 
2933790090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
653683
Product name
5-Nitro-2-oxindole
Purity
97%
Packaging
1g
Price
$43
Updated
2023/06/20
TRC
Product number
N496290
Product name
5-Nitroindolin-2-one
Packaging
100mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
N571
Product name
5-Nitro-2-oxindole
Packaging
1g
Price
$88
Updated
2021/12/16
Matrix Scientific
Product number
114820
Product name
5-Nitro-2,3-dihydro-1H-indol-2-one
Purity
97%
Packaging
1g
Price
$88
Updated
2021/12/16
SynQuest Laboratories
Product number
4H54-1-X2
Product name
5-Nitro-2-oxindole
Purity
96%
Packaging
10g
Price
$152
Updated
2021/12/16
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5-NITROOXINDOLE Chemical Properties,Usage,Production

Uses

  • Reactant for synthesis of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors
  • Reactant for preparation of Aurora kinase inhibitors
  • Reactant for synthesis of 3-substituted 2-indolinone RET inhibitors
  • Reactant for synthesis of 4-azachromeno[2,3-b]indol-11(6H)-ones and derivatives as analogs of ellipticine
  • Reactant for preparation of [18F]fluorobenzylidene-indolinone as possible tyrosine kinase inhibitor for PET tumor imaging
  • Reactant for preparation of 3-substituted indolin-2-ones as neuroprotective and toxic agents

Synthesis

59-48-3

20870-79-5

General procedure for the synthesis of 5-nitroindol-2-one from 2-indolone: 2-indolone (26 g) was dissolved in 100 mL of concentrated sulfuric acid at -15 °C and fuming nitric acid (8.4 mL) was added slowly and dropwise. The reaction temperature needs to be strictly controlled to ensure that it is maintained at -15 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred for 30 minutes. Subsequently, the reaction solution was carefully poured into ice water and a yellow precipitate was immediately generated. The precipitate was separated by filtration and 34 g of 5-nitroindol-2-one was finally obtained in 98% yield.

References

[1] Patent: US2005/256145, 2005, A1. Location in patent: Page/Page column 43
[2] Patent: US2005/256144, 2005, A1. Location in patent: Page/Page column 19
[3] Patent: US2010/75952, 2010, A1. Location in patent: Page/Page column 64
[4] Patent: EP2157093, 2010, A1. Location in patent: Page/Page column 61-62
[5] Patent: US6878733, 2005, B1. Location in patent: Page/Page column 169

5-NITROOXINDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-NITROOXINDOLE Suppliers

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View Lastest Price from 5-NITROOXINDOLE manufacturers

Honest Joy Holdings Limited
Product
5-Nitrooxindole 20870-79-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98.1%
Supply Ability
100 tons
Release date
2022-01-26
Chemwill Asia Co.,Ltd.
Product
5-Nitro-2-oxindole; 5-NITROOXINDOLE; in stock Factory 20870-79-5
Price
US $1.00/kg
Min. Order
1kg
Purity
High quality purified Factory in China
Supply Ability
Top 3 production capacity Factory
Release date
2019-04-03
Career Henan Chemical Co
Product
5-NITROOXINDOLE 20870-79-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 362
Release date
2019-09-01

20870-79-5, 5-NITROOXINDOLERelated Search:

5-NITROOXINDOLE 5-Nitroisatin 5,7-DINITROOXINDOLE 7-NITROOXINDOLE 5-Nitroindole Oxindole 1-METHYL-5-NITRO-ISATIN 1-(2,4-DICHLOROBENZYL)-5-NITRO-3-[(PENTANOYLOXY)IMINO]-1,3-DIHYDRO-2H-INDOL-2-ONE AURORA 4248 1-(4-CHLOROBENZYL)-5-NITRO-1H-INDOLE-2,3-DIONE 3-OXIME 1-(4-CHLOROBENZYL)-5-NITRO-3-[(PENTANOYLOXY)IMINO]-1,3-DIHYDRO-2H-INDOL-2-ONE 1-(2,4-DICHLOROBENZYL)-5-NITRO-1H-INDOLE-2,3-DIONE 3-([(2-CHLOROACETYL)OXY]IMINO)-1-(4-CHLOROBENZYL)-5-NITRO-1,3-DIHYDRO-2H-INDOL-2-ONE 1-(4-CHLOROBENZYL)-3-([(2,2-DICHLOROACETYL)OXY]IMINO)-5-NITRO-1,3-DIHYDRO-2H-INDOL-2-ONE 1-(4-CHLOROBENZYL)-3-([(3-CHLOROPROPANOYL)OXY]IMINO)-5-NITRO-1,3-DIHYDRO-2H-INDOL-2-ONE 1-(4-CHLOROBENZYL)-3-([(3-METHYLBUTANOYL)OXY]IMINO)-5-NITRO-1,3-DIHYDRO-2H-INDOL-2-ONE 1-methyl-5-nitro-1,3-dihydro-2H-indol-2-one 7-METHYL-5-NITRO-1H-INDOLE-2,3-DIONE

  • 5-NITRO-1,3-DIHYDROINDOLE-2-ONE
  • 5-NITROOXINDOLE
  • 5-NITRO-2-OXINDOLE
  • 2H-INDOL-2-ONE, 1,3-DIHYDRO-5-NITRO
  • 5-Nitrooxindole 96%
  • 5-Nitroindolin-2-one
  • 5-Nitrooxidole
  • 5-Nitro-1,3-dihydro-2H-indol-2-one
  • B71139
  • 5-Nitro-2-oxindole 96%
  • 1,3-Dihydro-5-nitro-2H-indol-2-one
  • 5-nitro-1H-indol-2-ol
  • 5-Nitro-1,3-dihydro-indol-2-one
  • NSC 25199
  • NSC 99066
  • 1,3-Dihydro-5-nitro-2H-indol-2-one, 5-Nitroindolin-2-one
  • 5-Nitro-2,3-dihydro-1H-indol-2-one
  • 5-Nitro-2-indolinone
  • 20870-79-5
  • C8H6N2O3
  • Heterocyclic Building Blocks
  • Indoles
  • Building Blocks
  • oxindoles
  • blocks
  • IndolesOxindoles
  • NitroCompounds
  • Indoles and derivatives
  • Indoline & Oxindole
  • Indoles