5-NITROOXINDOLE
- Product Name
- 5-NITROOXINDOLE
- CAS No.
- 20870-79-5
- Chemical Name
- 5-NITROOXINDOLE
- Synonyms
- 5-Nitroindolin-2-one;B71139;NSC 25199;NSC 99066;5-Nitrooxidole;5-NITROOXINDOLE;5-NITRO-2-OXINDOLE;5-Nitrooxindole 96%;5-Nitro-2-indolinone;5-nitro-1H-indol-2-ol
- CBNumber
- CB4341569
- Molecular Formula
- C8H6N2O3
- Formula Weight
- 178.14
- MOL File
- 20870-79-5.mol
5-NITROOXINDOLE Property
- Melting point:
- 233-236 °C
- Boiling point:
- 411.4±45.0 °C(Predicted)
- Density
- 1.449±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 12.61±0.20(Predicted)
- color
- Beige
- CAS DataBase Reference
- 20870-79-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-43
- Safety Statements
- 26-36/37
- WGK Germany
- 3
- Hazard Note
- Irritant/Keep Cold
- HS Code
- 2933790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 653683
- Product name
- 5-Nitro-2-oxindole
- Purity
- 97%
- Packaging
- 1g
- Price
- $43
- Updated
- 2023/06/20
- Product number
- N496290
- Product name
- 5-Nitroindolin-2-one
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- N571
- Product name
- 5-Nitro-2-oxindole
- Packaging
- 1g
- Price
- $88
- Updated
- 2021/12/16
- Product number
- 114820
- Product name
- 5-Nitro-2,3-dihydro-1H-indol-2-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $88
- Updated
- 2021/12/16
- Product number
- 4H54-1-X2
- Product name
- 5-Nitro-2-oxindole
- Purity
- 96%
- Packaging
- 10g
- Price
- $152
- Updated
- 2021/12/16
5-NITROOXINDOLE Chemical Properties,Usage,Production
Uses
- Reactant for synthesis of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors
- Reactant for preparation of Aurora kinase inhibitors
- Reactant for synthesis of 3-substituted 2-indolinone RET inhibitors
- Reactant for synthesis of 4-azachromeno[2,3-b]indol-11(6H)-ones and derivatives as analogs of ellipticine
- Reactant for preparation of [18F]fluorobenzylidene-indolinone as possible tyrosine kinase inhibitor for PET tumor imaging
- Reactant for preparation of 3-substituted indolin-2-ones as neuroprotective and toxic agents
Synthesis
59-48-3
20870-79-5
General procedure for the synthesis of 5-nitroindol-2-one from 2-indolone: 2-indolone (26 g) was dissolved in 100 mL of concentrated sulfuric acid at -15 °C and fuming nitric acid (8.4 mL) was added slowly and dropwise. The reaction temperature needs to be strictly controlled to ensure that it is maintained at -15 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred for 30 minutes. Subsequently, the reaction solution was carefully poured into ice water and a yellow precipitate was immediately generated. The precipitate was separated by filtration and 34 g of 5-nitroindol-2-one was finally obtained in 98% yield.
References
[1] Patent: US2005/256145, 2005, A1. Location in patent: Page/Page column 43
[2] Patent: US2005/256144, 2005, A1. Location in patent: Page/Page column 19
[3] Patent: US2010/75952, 2010, A1. Location in patent: Page/Page column 64
[4] Patent: EP2157093, 2010, A1. Location in patent: Page/Page column 61-62
[5] Patent: US6878733, 2005, B1. Location in patent: Page/Page column 169
5-NITROOXINDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-NITROOXINDOLE manufacturers
- Product
- 5-Nitrooxindole 20870-79-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.1%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- 5-Nitro-2-oxindole; 5-NITROOXINDOLE; in stock Factory 20870-79-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- High quality purified Factory in China
- Supply Ability
- Top 3 production capacity Factory
- Release date
- 2019-04-03
- Product
- 5-NITROOXINDOLE 20870-79-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 362
- Release date
- 2019-09-01