2-Chloro-4-methylaniline Property

Melting point:

7 °C (lit.)

Boiling point:

223-225 °C (lit.)

Density 

1.151 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.575(lit.)

Flash point:

211 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

methanol: soluble

form 

Liquid

pka

3.09±0.10(Predicted)

color 

Clear yellow to pale brown

BRN 

774514

Stability:

Acid Sensitive, Light Sensitive

CAS DataBase Reference

615-65-6(CAS DataBase Reference)

NIST Chemistry Reference

Benzenamine, 2-chloro-4-methyl-(615-65-6)

EPA Substance Registry System

Benzenamine, 2-chloro-4-methyl- (615-65-6)

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38-22-33

Safety Statements 

36/37-37/39-26-45-36/37/39

RIDADR 

UN 3429 6.1/PG 3

WGK Germany 

3

RTECS 

XU5110000

F 

8-9-23

Hazard Note 

Harmful

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29214200

Hazardous Substances Data

615-65-6(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H331Toxic if inhaled

H370Causes damage to organs

H372Causes damage to organs through prolonged or repeated exposure

H373May cause damage to organs through prolonged or repeated exposure

H402Harmful to aquatic life

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

2-Chloro-4-methylaniline Chemical Properties,Usage,Production

Description

2-Chloro-4-methylaniline was used in determination of aniline derivatives in environmental water samples using on-line combination of supported liquid membrane extraction and liquid chromatography. It was also used in determination of amines in environmental water samples by gas chromatography–mass spectrometry. It is an intermediate used to prepare reverse transcriptase inhibitors of HIV-1.

Chemical Properties

clear yellow to pale brown liquid

Chemical Properties

The chloromethylanilines are colorless or white crystalline solids or liquids, some have a mild fishy odor.

Uses

2-Chloro-4-methylaniline is an intermediate used to prepare reverse transcriptase inhibitors of HIV-1.

Uses

2-Chloro-4-methylaniline was used in determination of aniline derivatives in environmental water samples using on-line combination of supported liquid membrane extraction and liquid chromatography. It was also used in determination of amines in environmental water samples by gas chromatography–mass spectrometry.

Safety Profile

Poison by ingestion. A severe eye and skin irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of Cland NOx. See also other chloro toluidine entries.

Potential Exposure

Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill birds. It is marketed as pelleted bait for control of bird populations.

Shipping

UN2239 Chlorotoluidines, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3429 Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1- Poisonous materials

Incompatibilities

Incompatible with oxidizers, strong acids; chloroformates, and acid anhydrides, isocyanates, aldehydes forming fire and explosive hazards.