OLIGOMYCIN C

Product Name: OLIGOMYCIN C
CAS No.: 11052-72-5
Chemical Name: OLIGOMYCIN C
Synonyms: OLIGOMYCIN C;Oligmycin C;12-Deoxyoligomycin A;Oligomycin A, 12-deoxy-;OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-,(1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-
CBNumber: CB4354053
Molecular Formula: C45H74O10
Formula Weight: 775.06
MOL File: 11052-72-5.mol

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OLIGOMYCIN C Property

Boiling point:: 876.2±65.0 °C(Predicted)
Density: 1.091 g/cm3
storage temp.: −20°C
solubility: Soluble in DMSO
form: White to off-white powder.
pka: 13.49±0.70(Predicted)
Merck: 13,6902

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Safety

Hazard Codes: Xn
Risk Statements: 22
RIDADR: 2811
RTECS: RK3335000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 2941900000
Toxicity: LD50 ipr-mus: 8300 mg/kg JACSAT 80,6092,1958

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19162
Product name: Oligomycin C
Purity: ≥95%
Packaging: 1mg
Price: $364
Updated: 2024/03/01

Cayman Chemical

Product number: 19162
Product name: Oligomycin C
Purity: ≥95%
Packaging: 5mg
Price: $1088
Updated: 2024/03/01

Usbiological

Product number: O6154-02
Product name: Oligomycin C
Packaging: 1mg
Price: $523
Updated: 2021/12/16

TRC

Product number: O532985
Product name: OligomycinC
Packaging: 1mg
Price: $325
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003674
Product name: OLIGOMYCIN C
Purity: 95.00%
Packaging: 1MG
Price: $617.4
Updated: 2021/12/16

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OLIGOMYCIN C Chemical Properties,Usage,Production

Description

Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin C is a minor component of the oligomycin complex that acts as an inhibitor of the mitochondrial F₁F_O-ATP synthase. Inhibition of the ATP synthase by oligomycins leads to cell death.

Uses

Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.

Uses

Oligomycin C is an ATP synthetase and RVD inhibitor.

Safety Profile

A poison by intraperitoneal route.When heated to decomposition it emits acrid smoke andirritating vapors

IC 50

Macrolide

References

[1]. yang p w, li m g, zhao j y, et al. oligomycins a and c, major secondary metabolites isolated from the newly isolated strain streptomyces diastaticus[j]. folia microbiologica, 2010, 55(1): 10-16.
[2]. marton a, mihalik r, bratincsák a, et al. apoptotic cell death induced by inhibitors of energy conservation[j]. european journal of biochemistry, 1997, 250(2): 467-475.

OLIGOMYCIN C Preparation Products And Raw materials

Raw materials

Preparation Products

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OLIGOMYCIN C Suppliers

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11052-72-5, OLIGOMYCIN CRelated Search:

Lipopolysaccharides 3-Chloro-2-methylpropene Glutathione OLIGOMYCIN A oligomycin D oligomycin G OLIGOMYCIN oligomycin sensitivity-conferring protein oligomycin E Oligomycin F OLIGOMYCIN B,OLIGOMYCIN B, STREPTOMYCES DIASTATOCHROMOGENES,Oligomycin A, 28-oxo- ,Oligomycin B fromStreptomyces diastatochromogenes 44-homooligomycin A OLIGOMYCIN C OLIGOMYCIN A,OLIGOMYCIN COMPLEX,OLIGOMYCIN A, STREPTOMYCES DIASTATOCHROMOGENES,OLIGOMYCIN, STREPTOMYCES DIASTATOCHROMOGENES 44-homooligomycin B

12-Deoxyoligomycin A

Oligmycin C

OLIGOMYCIN C

OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES

Oligomycin A, 12-deoxy-

Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-

Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-,(1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-

11052-72-5

11053-72-5

C45H74O10

Antibiotics A to Z

Antibiotics N-S

BioChemical

Antibiotics

Antibiotics A to

Antibiotics by Application

Antibiotics N-SAntibiotics

AntifungalAntibiotics

Antineoplastic and Immunosuppressive AntibioticsAntibiotics

Chemical Structure Class

Inhibits an EnzymeAntibiotics

Macrolides

Mechanism of Action

Spectrum of Activity