ChemicalBook > CAS DataBase List > N-Methyl-N-(trimethylsilyl)acetamide

N-Methyl-N-(trimethylsilyl)acetamide

Product Name
N-Methyl-N-(trimethylsilyl)acetamide
CAS No.
7449-74-3
Chemical Name
N-Methyl-N-(trimethylsilyl)acetamide
Synonyms
N-METHYL-N-TRIMETHYLSILYLACETAMIDE;MOUSE ALBUMIN;N-Methyl-N-TMS-acetamide;[TriMethylsilylating Agent];N-METHYL-N-TRIMETHYLSILYACETAMIDE;N-Methyl-N-trimethylsilylacetamine;N-TRIMETHYLSILYL-N-METHYLACETAMIDE;n-methyl-n-(trimethylsilyl)-acetamid;Acetamide,N-methyl-N-(trimethylsilyl)-;MSA~N-Trimethylsilyl-N-methylacetamide
CBNumber
CB4355232
Molecular Formula
C6H15NOSi
Formula Weight
145.27
MOL File
7449-74-3.mol
More
Less

N-Methyl-N-(trimethylsilyl)acetamide Property

Boiling point:
159-161 °C(lit.)
Density 
0.904 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.439
Flash point:
48 °C
storage temp. 
-20°C
form 
lyophilized powder
pka
-0.11±0.70(Predicted)
color 
Clear light yellow
Specific Gravity
0.906
Sensitive 
Moisture Sensitive
BRN 
506975
InChI
InChI=1S/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3
InChIKey
QHUOBLDKFGCVCG-UHFFFAOYSA-N
SMILES
C(N(C)[Si](C)(C)C)(=O)C
CAS DataBase Reference
7449-74-3(CAS DataBase Reference)
NIST Chemistry Reference
Acetamide, n-methyl-n-(trimethylsilyl)-(7449-74-3)
EPA Substance Registry System
Acetamide, N-methyl-N-(trimethylsilyl)- (7449-74-3)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
10-36/37/38
Safety Statements 
37/39-16
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
F 
10-21
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29319090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
69480
Product name
N-Methyl-N-trimethylsilylacetamide
Purity
for GC derivatization, ≥97.0% (GC)
Packaging
10ml
Price
$189
Updated
2022/05/15
TCI Chemical
Product number
M0536
Product name
N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent]
Purity
>95.0%(GC)
Packaging
10g
Price
$92
Updated
2024/03/01
TCI Chemical
Product number
M0536
Product name
N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent]
Purity
>95.0%(GC)
Packaging
25g
Price
$179
Updated
2024/03/01
Alfa Aesar
Product number
L04101
Product name
N-Methyl-N-trimethylsilylacetamide, 98%
Packaging
2g
Price
$28.65
Updated
2024/03/01
Alfa Aesar
Product number
L04101
Product name
N-Methyl-N-trimethylsilylacetamide, 98%
Packaging
10g
Price
$69.65
Updated
2024/03/01
More
Less

N-Methyl-N-(trimethylsilyl)acetamide Chemical Properties,Usage,Production

Chemical Properties

clear light yellow liquid

Uses

N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:

  • Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.
  • Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.

Reactions

The interaction of N-Methyl-N-(trimethylsilyl)acetamide with chloromethyl(methyl)-diacetoxysilane led to the formation of 2,4,6-trimethyl-2,4-bis((N-methylacetamido)methyl)-1,3,5,2,4-trioxadisilinan-6-ylium chloride[1].

General Description

N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

Purification Methods

N-Methyl-N-trimethylsilylacetamide [7449-74-3] M 145.3, b 48 -49o/11mm, 8 4o/13mm, 105-107o/35mm (solid at room temperature), d 4 0.90, n D 1.4379. A likely impurity is Et3N.HCl which can be detected by its odour. If it is completely soluble in *C6H6, then redistil; otherwise dissolve it in this solvent, filter and evaporate first in a vacuum at 12mm, then fractionate; all operations should be carried out in a dry N2 atmosphere. [Klebe et al. J Am Chem Soc 88 3390 1966, Ried & Suarez-Rivero Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]

References

[1] Nataliya F. Lazareva, Igor M.Lazarev,lrina V.Sterkhova. "Trans-silylationof N-methyl-N-trimethylsilylacetamide with chloromethyl(methyl)diacetoxysilane."Journal of Organometallic Chemistry1006 (2023): Article 123000.

N-Methyl-N-(trimethylsilyl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-Methyl-N-(trimethylsilyl)acetamide Suppliers

Americas 1 Belgium 3 China 91 Europe 1 France 1 Germany 8 India 5 Italy 1 Japan 2 Switzerland 2 The Netherlands 1 United Kingdom 9 United States 32 Global 157
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9810
Advantage
59
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
7295
Advantage
60
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
Haimen Ruiyi Medical Tech Co., LTD
Tel
021-54718086
Fax
021-54711707
Email
sales5@ruiyitech.com
Country
China
ProdList
278
Advantage
58
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
5904
Advantage
65
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2886750 13927877953
Fax
0751-2886750
Email
3005811397@qq.com
Country
China
ProdList
13320
Advantage
58
Guangzhou Jhd Chemical Reagent Co., Ltd.
Tel
020-84383047
Fax
020-84380294
Email
sales@jhd.com.cn
Country
China
ProdList
9186
Advantage
65
Aikon International Limited
Tel
025-66113011 13155353615
Fax
(7)02557626880
Email
qzhang@aikonchem.com
Country
China
ProdList
15394
Advantage
58
Suzhou Siso new material Co.,Ltd.
Tel
0512-65402974 18550909935;
Fax
0512-67544899
Email
siso03@126.com
Country
China
ProdList
1904
Advantage
58
Jinan Kabotang Biological Technology Co.,Ltd.
Tel
0531-61320525 15866703830
Email
495745175@qq.com
Country
China
ProdList
7576
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-63315541 13323832564
Fax
QQ:3001332135
Email
3001332135@qq.com
Country
China
ProdList
10033
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52693
Advantage
58
Hunan chemfish Scientific co.,ltd
Tel
+8618229978283 19294230172
Email
sales@chemfish.com
Country
China
ProdList
4888
Advantage
58
Jinan Carbotang Biotech Co.,Ltd.
Tel
+8615866703830
Email
figo.gao@foxmail.com
Country
China
ProdList
8497
Advantage
58
Anhui Silicon Innovation Materials Technology Co., Ltd.
Tel
17201714774
Email
3317543774@qq.com
Country
China
ProdList
1042
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34563
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52849
Advantage
58
Baoji Guokang Bio-Technology Co., Ltd.
Tel
0917-3909592 13892490616
Fax
09173909592
Email
gksales1@gk-bio.com
Country
China
ProdList
9310
Advantage
58
HUNAN CHEMFISH SCIENTIFIC CO.,LTD
Tel
+86-0731-85567275 18932438858
Fax
QQ:3554193828
Email
sales05@chemfish.com
Country
China
ProdList
8355
Advantage
58
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
chemwill_asia@126.com
Country
CHINA
ProdList
23912
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39894
Advantage
58
Shenyang Maud Pharmaceutical Technology Co., Ltd.
Tel
024-23982345
Email
1020788318@qq.com
Country
China
ProdList
2251
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29809
Advantage
58
Hubei kefule Material Technology Co., Ltd
Tel
027-84459282 13720265353
Email
zhou@cfmats.com
Country
China
ProdList
881
Advantage
58
Hubei Co-Formula Material Tech Co., Ltd.
Tel
+86-27-84459282
Fax
+86-27-84459282
Email
sales@cfmats.com
Country
CHINA
ProdList
882
Advantage
58
Wuhan kemike Biomedical Technology Co., Ltd
Tel
027-87747081 18186681184
Email
1344475572@qq.com
Country
China
ProdList
7235
Advantage
58
Shandong Nayazuo Chemical Technology Co. LTD
Tel
400-873-6778 18660992876
Fax
0539-6267369
Email
3584419101@qq.com
Country
China
ProdList
4970
Advantage
58
Yantai Boyun Biological Technology Co. Ltd
Tel
13793517650; 13793517650
Email
2767277144@qq.com
Country
China
ProdList
2888
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 13451648594
Fax
0512-87182056
Email
sales@yacoo.com.cn
Country
China
ProdList
4578
Advantage
58
Shanghai kadel chemical technology co., LTD
Tel
021-4007787-550 400-7787-550
Email
2850202386@qq.com
Country
China
ProdList
10589
Advantage
58
Guangzhou Yunmen Biotechnology Co., Ltd
Tel
18902340307 18902340307
Fax
0751-2819901
Email
3356812514@qq.com
Country
China
ProdList
9244
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
39995
Advantage
58
Henan Kehong Biological Technology Co. LTD
Tel
0371-55969461； 0371-86658258 19139748274
Fax
QQ：3311217266
Email
info@kehobio.com
Country
China
ProdList
2555
Advantage
58
Shangqiu Ladybug Network Technology Co., LTD
Tel
17550092151
Fax
03702782809
Email
3628320093@qq.com
Country
China
ProdList
4206
Advantage
58
Changzhou Bojia Biomedical Technology Co., Ltd.
Tel
2122619822
Email
czbjpharma@126.com
Country
China
ProdList
18478
Advantage
58
More
Less

View Lastest Price from N-Methyl-N-(trimethylsilyl)acetamide manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
N-Methyl-N-trimethylsilylacetamide 7449-74-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
N-Methyl-N-trimethylsilylacetamide 7449-74-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
N-Methyl-N-(trimethylsilyl)acetamide 7449-74-3
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-01-12

7449-74-3, N-Methyl-N-(trimethylsilyl)acetamideRelated Search:

Acetamide Methyl acrylate TRIMETHOXYCHLOROSILANEDISC 05/06/04 N-Methylacetamide Methylparaben Methyl salicylate Kresoxim-methyl Methanol N,O-Bis(trimethylsilyl)acetamide Trimethylsilylacetylene Acetaminophen METSULFURON METHYL Basic Violet 1 Tribenuron methyl Lithium bis(trimethylsilyl)amide N,N-Dimethylacetamide Methyl N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide

  • N-Methyl-N-TMS-acetamide
  • Acetamide,N-methyl-N-(trimethylsilyl)-
  • 1-(4-phenylmethoxyphenyl)-2-propanamine
  • N-Methyl-N-trimethylsilyl-acetamide(MSA)
  • MSA~N-Trimethylsilyl-N-methylacetamide
  • N-Methyl-N-trimethylsilyacetamideMSA(N-Trimethylsilyl-N-methylacetamide)
  • N-Methyl-N-trimethylsilylacetamine
  • N-Methyl-N-(trimethylsilyl)acetamide,98%
  • N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent]
  • [TriMethylsilylating Agent]
  • N-Methyl-N-triMethylsilylacetaMide&nbsp
  • N-METHYL-N-TRIMETHYLSILYACETAMIDE
  • N-METHYL-N-TRIMETHYLSILYLACETAMIDE
  • N-TRIMETHYLSILYL-N-METHYLACETAMIDE
  • MOUSE ALBUMIN
  • n-methyl-n-(trimethylsilyl)-acetamid
  • N-Methyl-N-trimethylsilylacetamide[TrimethylsilylatingAgent]&gt
  • 7449-74-3
  • C6H15NOSi
  • Si (Classes of Silicon Compounds)
  • Silylacetamides
  • Si-N Compounds
  • Silylation (GC Derivatizing Reagents)
  • Trimethylsilylation (GC Derivatizing Reagents)
  • GC Derivatizing Reagents
  • Derivatization Reagents
  • Fluka Reagents
  • Analytical Chromatography Product Catalog
  • Analytical Chemistry
  • GC Derivatizing Reagents
  • Si (Classes of Silicon Compounds)
  • Silylacetamides
  • Silylation (GC Derivatizing Reagents)
  • Si-N Compounds
  • Trimethylsilylation (GC Derivatizing Reagents)