N-Methyl-N-(trimethylsilyl)acetamide

Product Name: N-Methyl-N-(trimethylsilyl)acetamide
CAS No.: 7449-74-3
Chemical Name: N-Methyl-N-(trimethylsilyl)acetamide
Synonyms: N-METHYL-N-TRIMETHYLSILYLACETAMIDE;MOUSE ALBUMIN;N-Methyl-N-TMS-acetamide;[TriMethylsilylating Agent];N-METHYL-N-TRIMETHYLSILYACETAMIDE;N-Methyl-N-trimethylsilylacetamine;N-TRIMETHYLSILYL-N-METHYLACETAMIDE;n-methyl-n-(trimethylsilyl)-acetamid;Acetamide,N-methyl-N-(trimethylsilyl)-;MSA~N-Trimethylsilyl-N-methylacetamide
CBNumber: CB4355232
Molecular Formula: C6H15NOSi
Formula Weight: 145.27
MOL File: 7449-74-3.mol

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N-Methyl-N-(trimethylsilyl)acetamide Property

Boiling point:: 159-161 °C(lit.)
Density: 0.904 g/mL at 20 °C(lit.)
refractive index: n20/D 1.439
Flash point:: 48 °C
storage temp.: -20°C
form: lyophilized powder
pka: -0.11±0.70(Predicted)
color: Clear light yellow
Specific Gravity: 0.906
Sensitive: Moisture Sensitive
BRN: 506975
InChI: InChI=1S/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3
InChIKey: QHUOBLDKFGCVCG-UHFFFAOYSA-N
SMILES: C(N(C)[Si](C)(C)C)(=O)C
CAS DataBase Reference: 7449-74-3(CAS DataBase Reference)
NIST Chemistry Reference: Acetamide, n-methyl-n-(trimethylsilyl)-(7449-74-3)
EPA Substance Registry System: Acetamide, N-methyl-N-(trimethylsilyl)- (7449-74-3)

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Safety

Hazard Codes: Xi
Risk Statements: 10-36/37/38
Safety Statements: 37/39-16
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
F: 10-21
TSCA: Yes
HazardClass: 3
PackingGroup: III
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 69480
Product name: N-Methyl-N-trimethylsilylacetamide
Purity: for GC derivatization, ≥97.0% (GC)
Packaging: 10ml
Price: $189
Updated: 2022/05/15

TCI Chemical

Product number: M0536
Product name: N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent]
Purity: >95.0%(GC)
Packaging: 10g
Price: $92
Updated: 2024/03/01

TCI Chemical

Product number: M0536
Product name: N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent]
Purity: >95.0%(GC)
Packaging: 25g
Price: $179
Updated: 2024/03/01

Alfa Aesar

Product number: L04101
Product name: N-Methyl-N-trimethylsilylacetamide, 98%
Packaging: 2g
Price: $28.65
Updated: 2024/03/01

Alfa Aesar

Product number: L04101
Product name: N-Methyl-N-trimethylsilylacetamide, 98%
Packaging: 10g
Price: $69.65
Updated: 2024/03/01

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N-Methyl-N-(trimethylsilyl)acetamide Chemical Properties,Usage,Production

Chemical Properties

clear light yellow liquid

Uses

N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:

Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.
Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.

Reactions

The interaction of N-Methyl-N-(trimethylsilyl)acetamide with chloromethyl(methyl)-diacetoxysilane led to the formation of 2,4,6-trimethyl-2,4-bis((N-methylacetamido)methyl)-1,3,5,2,4-trioxadisilinan-6-ylium chloride[1].

General Description

N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).

Purification Methods

N-Methyl-N-trimethylsilylacetamide [7449-74-3] M 145.3, b 48 -49o/11mm, 8 4o/13mm, 105-107o/35mm (solid at room temperature), d 4 0.90, n D 1.4379. A likely impurity is Et3N.HCl which can be detected by its odour. If it is completely soluble in *C6H6, then redistil; otherwise dissolve it in this solvent, filter and evaporate first in a vacuum at 12mm, then fractionate; all operations should be carried out in a dry N2 atmosphere. [Klebe et al. J Am Chem Soc 88 3390 1966, Ried & Suarez-Rivero Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]

References

[1] Nataliya F. Lazareva, Igor M.Lazarev,lrina V.Sterkhova. "Trans-silylationof N-methyl-N-trimethylsilylacetamide with chloromethyl(methyl)diacetoxysilane."Journal of Organometallic Chemistry1006 (2023): Article 123000.

N-Methyl-N-(trimethylsilyl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Methyl-N-(trimethylsilyl)acetamide Suppliers

Americas 1 Belgium 3 China 89 Europe 1 France 1 Germany 8 India 5 Italy 1 Japan 2 Switzerland 2 The Netherlands 1 United Kingdom 9 United States 32 Global 155

J & K SCIENTIFIC LTD.

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Alfa Aesar

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Energy Chemical

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Maya High Purity Chemicals

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Shanghai civi chemical technology co.,Ltd

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View Lastest Price from N-Methyl-N-(trimethylsilyl)acetamide manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-Methyl-N-trimethylsilylacetamide 7449-74-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-Methyl-N-trimethylsilylacetamide 7449-74-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: N-Methyl-N-(trimethylsilyl)acetamide 7449-74-3
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-12

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N-Methyl-N-trimethylsilyacetamideMSA(N-Trimethylsilyl-N-methylacetamide)

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N-Methyl-N-(trimethylsilyl)acetamide,98%

N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent]

[TriMethylsilylating Agent]

N-Methyl-N-triMethylsilylacetaMide&nbsp

N-METHYL-N-TRIMETHYLSILYACETAMIDE

N-METHYL-N-TRIMETHYLSILYLACETAMIDE

N-TRIMETHYLSILYL-N-METHYLACETAMIDE

MOUSE ALBUMIN

n-methyl-n-(trimethylsilyl)-acetamid

N-Methyl-N-trimethylsilylacetamide[TrimethylsilylatingAgent]&gt

7449-74-3

C6H15NOSi

Si (Classes of Silicon Compounds)

Silylacetamides

Si-N Compounds

Silylation (GC Derivatizing Reagents)

Trimethylsilylation (GC Derivatizing Reagents)

GC Derivatizing Reagents

Derivatization Reagents

Fluka Reagents

Analytical Chromatography Product Catalog

Analytical Chemistry

GC Derivatizing Reagents

Si (Classes of Silicon Compounds)

Silylacetamides

Silylation (GC Derivatizing Reagents)

Si-N Compounds

Trimethylsilylation (GC Derivatizing Reagents)