7-Ethoxycoumarin
- Product Name
- 7-Ethoxycoumarin
- CAS No.
- 31005-02-4
- Chemical Name
- 7-Ethoxycoumarin
- Synonyms
- ETHOXYCOUMARIN;7-ETHOXYCOUMARIN;ETHOXYCOUMARIN, 7-;Ethylumbelliferone;Coumarin, 7-ethoxy-;7-Ethoxycoumarin>7-Ethoxycoumarin ,99%;7-ethoxychromen-2-one;ETHOXYCOUMARIN, 7-(RG);7-O-Ethylumbelliferone
- CBNumber
- CB4357665
- Molecular Formula
- C11H10O3
- Formula Weight
- 190.2
- MOL File
- 31005-02-4.mol
7-Ethoxycoumarin Property
- Melting point:
- 88-90 °C (lit.)
- Boiling point:
- 265.69°C (rough estimate)
- Density
- 1.1803 (rough estimate)
- refractive index
- 1.4260 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Off-White to Pale Brown
- Water Solubility
- Soluble in hot methanol (very faint turbidity), 95% ethanol (50 mg/ml), DMF, and DMSO. Insoluble in water.
- BRN
- 146200
- LogP
- 2.310 (est)
- CAS DataBase Reference
- 31005-02-4(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- E1379
- Product name
- 7-Ethoxycoumarin
- Packaging
- 25mg
- Price
- $18.18
- Updated
- 2024/03/01
- Product number
- E1379
- Product name
- 7-Ethoxycoumarin
- Packaging
- 1g
- Price
- $334
- Updated
- 2024/03/01
- Product number
- E0538
- Product name
- 7-Ethoxycoumarin
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $162
- Updated
- 2024/03/01
- Product number
- E0538
- Product name
- 7-Ethoxycoumarin
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $486
- Updated
- 2024/03/01
- Product number
- L14116
- Product name
- 7-Ethoxycoumarin, 99%
- Packaging
- 100mg
- Price
- $42.65
- Updated
- 2024/03/01
7-Ethoxycoumarin Chemical Properties,Usage,Production
Description
7-Ethoxycoumarin is oneof the general substrates for liver cytochrome P450 enzymes, and it is known that CYP1A1,1A2, and 2B1, drug inducedtypes (b-naphthoflavone, isosafrole, and phenobarbital,re-spectively, in rat liver) are mainly responsible for the ECDE activity in the liver.
Chemical Properties
BEIGE CRYSTALLINE POWDER
Uses
7-Ethoxycoumarin is a substrate for CYP2B6 used in fluorometric assays of microsomal monooxygenase activity.
Uses
7-Ethoxycoumarin is commonly used for metabolism studies, including hepatocyte studies, liver perfusion techniques and cytochrome P450 studies.
7-Ethoxycoumarin has been used to study the functional activity of recombinant P450. ) It has also been used as an internal standard for in vitro S-warfarin 7-hydroxylation and high performance liquid chromatography (HPLC) analysis.
Definition
ChEBI: 7-ethoxycoumarin is a member of the class of coumarins that is umbelliferone in which the hydroxy group at position 7 is replaced by an ethoxy group. It is an aromatic ether and a member of coumarins. It derives from an umbelliferone.
Biochem/physiol Actions
7-Ethoxycoumarin is a cytochrome P450 substrate.
Metabolism
7-Ethoxycoumarin is metabolized by many cytochrome P450 enzymes active in foreign compound metabolism and has been used as a prototypic substrate to monitor P450 (P450) activity in both hepatic and extrahepatic tissues.
The in vitro perfusion of the human placental lobule with 7-ethoxycoumarin gives 7-hydroxycoumarin, and perfusion with androstenedione gives the conversion products, estrone, estradiol, and testosterone. The human placenta has only a limited capacity for the metabolism of xenobiotics.
Use of 7-Ethoxycoumarin to Monitor Multiple Enzymes in the Human CYP1, CYP2, and CYP3 Families
7-Ethoxycoumarin Preparation Products And Raw materials
Raw materials
Preparation Products
7-Ethoxycoumarin Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-61259108 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44688
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14103
- Advantage
- 59
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15402
- Advantage
- 60
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18738
- Advantage
- 57
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
View Lastest Price from 7-Ethoxycoumarin manufacturers
- Product
- 7-Ethoxycoumarin 31005-02-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-28
- Product
- 7-Ethoxycoumarin 31005-02-4
- Price
- US $40.00-3.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-12
- Product
- 7-ETHOXYCOUMARIN 31005-02-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-29