Carnosic acid

ChemicalBook > CAS DataBase List > Carnosic acid

Description References

Product Name: Carnosic acid
CAS No.: 3650-09-7
Chemical Name: Carnosic acid
Synonyms: (4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-4a-carboxylic Acid;salvin;carnosicaci;carosic acid;CARNOSIC ACID;CARNOSOLIC ACID;CARNOSIC ACID(P);CARNOSIC ACID(RG);Carnosic Acid >carnosic acid oil
CBNumber: CB4367749
Molecular Formula: C20H28O4
Formula Weight: 332.43
MOL File: 3650-09-7.mol

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Carnosic acid Property

Melting point:: 190°C(lit.)
Boiling point:: 506.4±50.0 °C(Predicted)
Density: 1.184±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: powder
pka: 4.14±0.40(Predicted)
color: yellow
BRN: 2707918
InChIKey: QRYRORQUOLYVBU-VBKZILBWSA-N
LogP: 5.405 (est)
CAS DataBase Reference: 3650-09-7(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29182900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2208
Product name: Carnosic Acid
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 20mg
Price: $161
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL89171
Product name: Carnosic acid
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $308
Updated: 2024/03/01

Sigma-Aldrich

Product number: 05330590
Product name: Carnosic acid
Purity: primary reference standard
Packaging: 10mg
Price: $825
Updated: 2024/03/01

Sigma-Aldrich

Product number: 91209
Product name: Carnosic acid
Purity: analytical standard
Packaging: 5mg
Price: $289
Updated: 2022/05/15

TCI Chemical

Product number: C2488
Product name: Carnosic Acid
Purity: >97.0%(HPLC)
Packaging: 20mg
Price: $99
Updated: 2024/03/01

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Carnosic acid Chemical Properties,Usage,Production

Description

Carnosic acid (salvin) is abundant in sage and rosemary leaves. It has antioxidative, anti-carcinogenic, anti-inflammatory, anti-microbial, anti-adipogenic, antiproliferative, antitumorigenic and neuroprotective properties. It is increasingly exploited within food, nutrition health, and cosmetic industries. It is used as the main active antioxidants of food additives in Europe, in products including oils, animal fats, sauces, bakery wares, meat, and fish products etc. to prevent oxidation and prolong their storage time. It is proven to be efficient in the treatment of hyperglycemia. In cosmetic industry, it is used in the hair care and skin care products. Oral health care is another cosmetics-related application of carnosic acid: in vitro studies have shown that it efficiently protected against typical cariogenic microorganisms. It is the important raw material of tooth grinding and gargle agent.

References

[1] Simona Birtic, Pierre Dussort, Francois-Xavier Pierre, Antoine C. Bily, Marc Roller (2015) Carnosic acid,115, 9-19
[2] https://en.wikipedia.org/wiki/Carnosic_acid
[3] http://www.lvyinbio.com/plant-extract/carnosic-acid/

Chemical Properties

Yellow powder

Uses

Carnosic Acid is a phenolic component of rosemary. It acts as a potent antioxdant and also has UV protective activity. Specifically protection for UV-A radiation and damage. Carnosic Acid also inhibits the free-radical chain reaction that leads to the oxidation of fats and oils, thereby stabilizing and increasing the shelf life of meats.

Definition

ChEBI: An abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20. It is isolated from Rosmarinus officinalis and exhibits anti-angiogenic, antineoplastic, antioxidant and anti-HIV activity.

Anticancer Research

Carnosic acid is a diterpene found in rosemary (Rosmarinus officinalis), exhibitinganti-proliferative effects when observed in vitro in human renal carcinoma cells andcervical carcinoma cells (Su et al. 2016) including inhibition of cell proliferation,angiogenesis and cell migration. ER stress is induced by the carnosic acid present inthe extract from rosemary, inducing cancer cell apoptosis (Cao and Kaufman 2014;Petiwala et al. 2014). Carnosic acid induced dose-dependent expression of ATF4and CHOP and knockdown of CHOP and ATF4 by siRNA-suppressed apoptosis.
The role of ROS was investigated in the induction of ER stress by carnosic acid.ATF4 and CHOP expression induced by carnosic acid was markedly inhibited byROS scavengers. Hence, this information implies that ATF4 and CHOP expressionmediated by ER stress plays a significant part in apoptosis of human kidney Cakicells induced by carnosic acid (Min et al. 2014). Treatment of 22Rv1 and LNCaP,human prostate cancer cell lines, by carnosic acid degraded the androgen receptor(AR), and antigen specific to the prostate also showed reduced expression.Proteasomal degradation pathway dependent on ER stress mediates AR degradation.Induction of CHOP protein, degradation of AR and reduction in the growth ofxenograft prostate cancer tumours by 53% were also detected in vivo. Additionally,carnosic acid induces ER stress only in prostate cancer cells and not in normal cells(Petiwala et al. 2016).

Carnosic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Carnosic acid manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Rosemary Extract Carnosic Acid Powder 3650-09-7
Price: US $180.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-04-23

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Miltiorrhiza Extract Tanshinone 3650-09-7
Price: US $180.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-04-23

Wuhan Haorong Biotechnology Co.,Ltd

Product: Carnosic acid 3650-09-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500
Release date: 2023-08-02

3650-09-7, Carnosic acidRelated Search:

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CARNOSOLIC ACID

CARNOSIC ACID

4a(2H)-Phenanthrenecarboxylic acid, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,10aS)-

(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid

CARNOSIC ACID(P)

CARNOSIC ACID(P)(NOW AVAILABLE IN GRAM SIZES)(P)

salvin

(4aR-trans)-1,3,4,9,10,10a-Hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-4a(2H)-phenanthrenecarboxylic acid

Carnosic acid from Rosmarinus officinalis

CARNOSIC ACID(RG)

Carnosic Acid, Free Acid, >99%

Deoxypicrosalvinic acid

Carnosic acid, 99%, from Rosmarinus officinalis L.

1,3,4,9,10,10aS-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-4aR(2H)-phenanthrenecarboxylic acid Carnosic acid

Carnosic acid, >=95%

Carnosic Acid (Synthetic)

Soluble CARNOSIC ACID, Liposomal CARNOSIC ACID, CARNOSIC ACID NanoEmulsion, NanoActive CARNOSIC ACID, BETA- CARNOSIC ACID

Carnosic acid, 99%, from Rosmarinus officinalis

Carnosic acid 5-95%

Carnosic Acid &gt

carnosicaci

(4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-4a-carboxylic Acid

hot selling Carnosic acid

Carnosic acid USP/EP/BP

carnosic acid oil

carosic acid

Murine tail oxalic acid

Rosemary Extract Carnosic Acid Powder

Miltiorrhiza Extract Tanshinone

CARNOSIC ACID(RG) 10mg

CARNOSIC ACID(RG) 1g

CARNOSIC ACID(RG) 250mg

CARNOSIC ACID(RG) 25mg

3650-09-7

360-09-7

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