Description Reference
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2-AMINO-5-CHLOROBENZOPHENONE OXIME

Description Reference
Product Name
2-AMINO-5-CHLOROBENZOPHENONE OXIME
CAS No.
18097-52-4
Chemical Name
2-AMINO-5-CHLOROBENZOPHENONE OXIME
Synonyms
AKOS 90376;TIMTEC-BB SBB003174;Oxazepam Impurity 3;Mixtureofsyn-andanti-isomeres;2-Amino-5-Chlor-Benzophenonoxim;2-Amino-5-Chlorobenzopheone Oxime;2-AMINO-5-CHLOROBENZOPHENONE OXIME;2-AMINO-5-CHLOROBENZOPHENEONE OXIME;2-Amino-5-chlorobenzophenoneα-oxime-,(Z)-;(2-amino-5-chlorophenyl)phenyl-methanonoxime
CBNumber
CB4368100
Molecular Formula
C13H11ClN2O
Formula Weight
246.69
MOL File
18097-52-4.mol
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2-AMINO-5-CHLOROBENZOPHENONE OXIME Property

Melting point:
117-120oC
Boiling point:
434.9±45.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form 
Solid
pka
10.20±0.28(Predicted)
color 
Pale Yellow to Light Yellow
EPA Substance Registry System
Methanone, (2-amino-5-chlorophenyl)phenyl-, oxime (18097-52-4)
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Safety

Safety Statements 
24/25
HS Code 
29280090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S413445
Product name
2-AMINO-5-CHLOROBENZOPHENONE OXIME (MIXTURE OF SYN AND ANTI ISOMERS)
Purity
Aldrich
Packaging
1g
Price
$179
Updated
2024/03/01
TRC
Product number
A603730
Product name
2-Amino-5-chlorobenzophenoneOxime(E/Zmixture)
Packaging
1g
Price
$45
Updated
2021/12/16
TRC
Product number
A603730
Product name
2-Amino-5-chlorobenzophenoneOxime(E/Zmixture)
Packaging
5G
Price
$110
Updated
2021/12/16
Usbiological
Product number
002114
Product name
2-Amino-5-chlorobenzophenone Oxime
Packaging
250mg
Price
$312
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA67520
Product name
2-Amino-5-chlorobenzophenone oxime
Packaging
5G
Price
$100
Updated
2021/12/16
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2-AMINO-5-CHLOROBENZOPHENONE OXIME Chemical Properties,Usage,Production

Description

2-Amino-5-Chlorobenzophenone is in the form of a yellow-brown crystalline powder. Its melting point is 98-100°C. It is used to produce intermediates for the synthesis of Oxazolam drug and intermediates for psychotherapeutic agents, such as chlorodiazepoxide and diazepam.1,2

Reference

  1. R. Liao, Synthetic method of Oxazolam drug intermediate 2-amino-5-chlorobenzophenone, Patent CN105461576A
  2. S. Nakanishi, W. E. Barth, Process for preparing 6-chloromethyl-4-phenylquinazoline-3-oxide and intermediates therefor, Patent US3932325A

Chemical Properties

yellow crystalline powder

Uses

Intermediate in the preparation of Chlordiazepoxide (C327050) and its metabolites.

Definition

ChEBI: (2-amino-5-chlorophenyl)(phenyl)methanone oxime is a diarylmethane.

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 3957, 1965 DOI: 10.1021/jo01022a519

2-AMINO-5-CHLOROBENZOPHENONE OXIME Preparation Products And Raw materials

Raw materials

75% ethanol 2-Amino-5-chlorobenzophenone Isoxazole Water Hydroxylamine hydrochloride

Preparation Products

Chlordiazepoxide 7-chloro-1,3-dihydro-5-phenyl-2-oxo-2H-1,4-benzodiazepin-3-yl acetate Demoxepam 6-CHLORO-2-(CHLOROMETHYL)-3-OXIDO-4-PHENYL-QUINAZOLINE
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2-AMINO-5-CHLOROBENZOPHENONE OXIME Suppliers

Belgium 1 Canada 1 China 40 France 1 Germany 2 India 1 Japan 1 United Kingdom 7 United States 7 Global 61
Acros Organics
Tel
--
Fax
--
Email
info@acros.com
Country
Belgium
ProdList
6772
Advantage
81

18097-52-4, 2-AMINO-5-CHLOROBENZOPHENONE OXIMERelated Search:

Benzophenone oxime 2-Amino-5-chlorobenzophenone Cyprazepam Chlordiazepoxide Demoxepam 2-AMINO-5-CHLOROBENZOPHENONE OXIME 7-Chloro-2-oxo-5-(2-chlorophenyl)-1,4-benzodiazepine-4-oxide CHLORDIAZEPOXIDE HYDROCHLORIDE 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 2,5-Dioxide 1-ACETOXYMETHYL-8-CHLORO-6-(2-FLUOROPHENYL)-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE 5-OXIDE NORCHLORDIAZEPOXIDE CHLORDIAZEPOXIDE-D5 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 5-Oxide Alprazolam 5-Oxide (E)-2-Amino-5-chlorobenzophenone oxime (Z)-2-Amino-5-chlorobenzophenone oxime N-nitrosochlordiazepoxide 2-CHLORO-N-(4-CHLORO-2-[(HYDROXYIMINO)(3-HYDROXYPHENYL)METHYL]PHENYL)ACETAMIDE

  • 2-AMINO-5-CHLOROBENZOPHENEONE OXIME
  • 2-AMINO-5-CHLOROBENZOPHENONE OXIME
  • AKOS 90376
  • TIMTEC-BB SBB003174
  • (2-amino-5-chlorophenyl)phenyl-methanonoxime
  • 2-amino-5-chlorobenzophenoneoxime,mixtureofsynandantiisomers
  • 2-Amino-5-chlorobenzophenoneα-oxime-,(Z)-
  • Mixtureofsyn-andanti-isomeres
  • Methanone,(2-amino-5-chlorophenyl)phenyl-,oxime
  • 2-AMINO-5-CHLOROBENZOPHENONE OXIME, 98%, MIXTURE OF SYN AND ANTI ISOMERS
  • 2-Amino-5-Chlorobenzopheone Oxime
  • 2-Amino-5-chlorobenzophenone Oxime (E/Z mixture)
  • Methanone, (2-amino-5-chlorophenyl)phenyl-, oxime (9CI, ACI)
  • (2-amino-5-chlorophenyl)phenyl-Methanone oxime (9CI ACI)
  • 2-Amino-5-Chlor-Benzophenonoxim
  • Oxazepam Impurity 3
  • 18097-52-4
  • Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes