ChemicalBook > CAS DataBase List > 2-AMINO-5-CHLOROBENZOPHENONE OXIME

2-AMINO-5-CHLOROBENZOPHENONE OXIME

Description Reference

Product Name: 2-AMINO-5-CHLOROBENZOPHENONE OXIME
CAS No.: 18097-52-4
Chemical Name: 2-AMINO-5-CHLOROBENZOPHENONE OXIME
Synonyms: AKOS 90376;TIMTEC-BB SBB003174;Oxazepam Impurity 3;Diazepam Impurity 20;Mixtureofsyn-andanti-isomeres;2-Amino-5-Chlor-Benzophenonoxim;2-Amino-5-Chlorobenzopheone Oxime;2-AMINO-5-CHLOROBENZOPHENONE OXIME;2-AMINO-5-CHLOROBENZOPHENEONE OXIME;2-Amino-5-chlorobenzophenoneα-oxime-,(Z)-
CBNumber: CB4368100
Molecular Formula: C13H11ClN2O
Formula Weight: 246.69
MOL File: 18097-52-4.mol

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2-AMINO-5-CHLOROBENZOPHENONE OXIME Property

Melting point:: 117-120oC
Boiling point:: 434.9±45.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form: Solid
pka: 10.20±0.28(Predicted)
color: Pale Yellow to Light Yellow
EPA Substance Registry System: Methanone, (2-amino-5-chlorophenyl)phenyl-, oxime (18097-52-4)

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Safety

Safety Statements: 24/25
HS Code: 29280090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S413445
Product name: 2-AMINO-5-CHLOROBENZOPHENONE OXIME (MIXTURE OF SYN AND ANTI ISOMERS)
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: S413445
Product name: 2-AMINO-5-CHLOROBENZOPHENONE OXIME (MIXTURE OF SYN AND ANTI ISOMERS)
Purity: Aldrich
Packaging: 1g
Price: $179
Updated: 2024/03/01

TRC

Product number: A603730
Product name: 2-Amino-5-chlorobenzophenoneOxime(E/Zmixture)
Packaging: 1g
Price: $45
Updated: 2021/12/16

TRC

Product number: A603730
Product name: 2-Amino-5-chlorobenzophenoneOxime(E/Zmixture)
Packaging: 5G
Price: $110
Updated: 2021/12/16

Usbiological

Product number: 002114
Product name: 2-Amino-5-chlorobenzophenone Oxime
Packaging: 250mg
Price: $312
Updated: 2021/12/16

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2-AMINO-5-CHLOROBENZOPHENONE OXIME Chemical Properties,Usage,Production

Description

2-Amino-5-Chlorobenzophenone is in the form of a yellow-brown crystalline powder. Its melting point is 98-100°C. It is used to produce intermediates for the synthesis of Oxazolam drug and intermediates for psychotherapeutic agents, such as chlorodiazepoxide and diazepam.^1,2

Reference

R. Liao, Synthetic method of Oxazolam drug intermediate 2-amino-5-chlorobenzophenone, Patent CN105461576A
S. Nakanishi, W. E. Barth, Process for preparing 6-chloromethyl-4-phenylquinazoline-3-oxide and intermediates therefor, Patent US3932325A

Chemical Properties

yellow crystalline powder

Uses

Intermediate in the preparation of Chlordiazepoxide (C327050) and its metabolites.

Definition

ChEBI: (2-amino-5-chlorophenyl)(phenyl)methanone oxime is a diarylmethane.

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 3957, 1965 DOI: 10.1021/jo01022a519

2-AMINO-5-CHLOROBENZOPHENONE OXIME Preparation Products And Raw materials

Raw materials

75% ethanol 2-Amino-5-chlorobenzophenone Isoxazole Water Hydroxylamine hydrochloride

Preparation Products

Chlordiazepoxide 7-chloro-1,3-dihydro-5-phenyl-2-oxo-2H-1,4-benzodiazepin-3-yl acetate Demoxepam 6-CHLORO-2-(CHLOROMETHYL)-3-OXIDO-4-PHENYL-QUINAZOLINE

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2-AMINO-5-CHLOROBENZOPHENONE OXIME Suppliers

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18097-52-4, 2-AMINO-5-CHLOROBENZOPHENONE OXIMERelated Search:

Benzophenone oxime 2-Amino-5-chlorobenzophenone Cyprazepam Chlordiazepoxide Demoxepam 2-AMINO-5-CHLOROBENZOPHENONE OXIME 7-Chloro-2-oxo-5-(2-chlorophenyl)-1,4-benzodiazepine-4-oxide CHLORDIAZEPOXIDE HYDROCHLORIDE 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 2,5-Dioxide 1-ACETOXYMETHYL-8-CHLORO-6-(2-FLUOROPHENYL)-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE 5-OXIDE NORCHLORDIAZEPOXIDE CHLORDIAZEPOXIDE-D5 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 5-Oxide Alprazolam 5-Oxide (E)-2-Amino-5-chlorobenzophenone oxime (Z)-2-Amino-5-chlorobenzophenone oxime N-nitrosochlordiazepoxide 2-CHLORO-N-(4-CHLORO-2-[(HYDROXYIMINO)(3-HYDROXYPHENYL)METHYL]PHENYL)ACETAMIDE

2-AMINO-5-CHLOROBENZOPHENEONE OXIME

2-AMINO-5-CHLOROBENZOPHENONE OXIME

AKOS 90376

TIMTEC-BB SBB003174

(2-amino-5-chlorophenyl)phenyl-methanonoxime

2-amino-5-chlorobenzophenoneoxime,mixtureofsynandantiisomers

2-Amino-5-chlorobenzophenoneα-oxime-,(Z)-

Mixtureofsyn-andanti-isomeres

Methanone,(2-amino-5-chlorophenyl)phenyl-,oxime

2-AMINO-5-CHLOROBENZOPHENONE OXIME, 98%, MIXTURE OF SYN AND ANTI ISOMERS

2-Amino-5-Chlorobenzopheone Oxime

2-Amino-5-chlorobenzophenone Oxime (E/Z mixture)

Methanone, (2-amino-5-chlorophenyl)phenyl-, oxime (9CI, ACI)

(2-amino-5-chlorophenyl)phenyl-Methanone oxime (9CI ACI)

2-Amino-5-Chlor-Benzophenonoxim

Oxazepam Impurity 3

2-Amino-5-chlorobenzophenone oxime - Bio-X ?

Diazepam Impurity 20

18097-52-4

Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes