ChemicalBook > CAS DataBase List > 4-Chloro-3-hydroxybenzoic acid

4-Chloro-3-hydroxybenzoic acid

Product Name
4-Chloro-3-hydroxybenzoic acid
CAS No.
34113-69-4
Chemical Name
4-Chloro-3-hydroxybenzoic acid
Synonyms
TIMTEC-BB SBB008503;5-Carboxy-2-chlorophenol;4-chloro-3-hydroxybenzoicaci;4-CHLORO-3-HYDROXYBENZOIC ACID;Benzoic acid, 4-chloro-3-hydroxy-;4-Chloro-3-hydroxybenzoic Acid, 97+%;4-CHLORO-3-HYDROXYBENZOIC ACID ---PURITY 98%---
CBNumber
CB4368988
Molecular Formula
C7H5ClO3
Formula Weight
172.57
MOL File
34113-69-4.mol
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4-Chloro-3-hydroxybenzoic acid Property

Melting point:
219.5-220.5 °C
Boiling point:
345.4±27.0 °C(Predicted)
Density 
1.536±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO, Methanol
form 
Solid
pka
3.85±0.10(Predicted)
color 
Light Beige
InChI
InChI=1S/C7H5ClO3/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,9H,(H,10,11)
InChIKey
SCPUNJAMWFAYED-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=C(Cl)C(O)=C1
CAS DataBase Reference
34113-69-4(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 4-chloro-3-hydroxy-(34113-69-4)
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Safety

Hazard Codes 
Xi
Hazard Note 
Irritant
HS Code 
2918199890
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C366565
Product name
4-Chloro-3-hydroxybenzoicAcid
Packaging
1g
Price
$120
Updated
2021/12/16
Usbiological
Product number
161302
Product name
4-Chloro-3-hydroxybenzoic Acid
Packaging
1g
Price
$403
Updated
2021/12/16
TRC
Product number
C366565
Product name
4-Chloro-3-hydroxybenzoicAcid
Packaging
25g
Price
$470
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC70409
Product name
4-Chloro-3-hydroxybenzoic acid
Packaging
100g
Price
$600
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0013088
Product name
4-CHLORO-3-HYDROXYBENZOIC ACID
Purity
95.00%
Packaging
1G
Price
$682.28
Updated
2021/12/16
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4-Chloro-3-hydroxybenzoic acid Chemical Properties,Usage,Production

Uses

4-Chloro-3-hydroxy-Benzoic Acid acts as a potential inhibitor of influenza endonuclease used in the treatment of influenza. Also used in the synthesis of highly selective Tie-2 kinase inhibitors used in the treatment of tumors.

Synthesis

931409-94-8

34113-69-4

General procedure for the synthesis of 4-chloro-3-hydroxybenzoic acid from compound (CAS: 931409-94-8): boron tribromide (1 M in dichloromethane, 31 mL, 31.504 mmol) was slowly added dropwise to a solution of compound 38 (3.56 g, 15.752 mmol) in dichloromethane (30 mL) under ice bath cooling conditions. The reaction mixture was stirred at 0°C to room temperature for 18 hours. Upon completion of the reaction, the reaction was quenched with 0.88 aqueous ammonia solution and stirring was continued for 90 minutes at room temperature. Subsequently, the reaction mixture was acidified to pH 1 by dropwise addition of 2N aqueous hydrochloric acid solution and then extracted with ether (2 x 50 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 4-chloro-3-hydroxybenzoic acid as a light yellow solid in 90% yield (2.45 g). The product was characterized by 1H NMR (400 MHz, CD3OD): δ 7.36-7.38 (d, 1H), 7.44-7.47 (dd, 1H), 7.54-7.55 (d, 1H); LRMS APCI m/z 171 [M-H]-.

References

[1] Patent: WO2007/34325, 2007, A1. Location in patent: Page/Page column 53

4-Chloro-3-hydroxybenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Chloro-3-hydroxybenzoic acid manufacturers

Career Henan Chemical Co
Product
4-Chloro-3-hydroxybenzoic acid 34113-69-4
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-01-31

34113-69-4, 4-Chloro-3-hydroxybenzoic acidRelated Search:

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  • 4-CHLORO-3-HYDROXYBENZOIC ACID
  • 4-CHLORO-3-HYDROXYBENZOIC ACID ---PURITY 98%---
  • TIMTEC-BB SBB008503
  • 5-Carboxy-2-chlorophenol
  • 4-Chloro-3-hydroxybenzoic Acid, 97+%
  • Benzoic acid, 4-chloro-3-hydroxy-
  • 4-chloro-3-hydroxybenzoicaci
  • 34113-69-4
  • 1571-12-8
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Carboxylic Acids
  • Phenyls & Phenyl-Het
  • Carboxylic Acids
  • Phenyls & Phenyl-Het