ChemicalBook > CAS DataBase List > CGP 20712 A

CGP 20712 A

Product Name
CGP 20712 A
CAS No.
105737-62-0
Chemical Name
CGP 20712 A
Synonyms
CGP207122HCl;CGP 20712 mesylate;CGP 20712 DIHYDROCHLORIDE;CGP-20712A methanesulfonate salt;CGP 20712A METHANESULFONATE SELECTIVE B1 ADRENOCE;CGP-20712A methanesulfonate salt solid, >=98% (HPLC);1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy)-2-propanoldihyd;1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazoyl)phenoxy]-2-propanol mesylate;1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE;(+/-)-1-(2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy)-2-propanol methane sulfonate
CBNumber
CB4380786
Molecular Formula
C24H29F3N4O8S
Formula Weight
590.57
MOL File
105737-62-0.mol
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CGP 20712 A Property

storage temp. 
2-8°C
solubility 
H2O: 10 mg/mL
form 
solid
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C231
Product name
CGP-20712A methanesulfonate salt
Purity
solid, ≥98% (HPLC)
Packaging
10mg
Price
$195.6
Updated
2024/03/01
Sigma-Aldrich
Product number
C231
Product name
CGP-20712A methanesulfonate salt
Purity
solid, ≥98% (HPLC)
Packaging
50mg
Price
$1270
Updated
2023/01/07
Tocris
Product number
1024
Product name
CGP20712dihydrochloride
Purity
≥96%(HPLC)
Packaging
50
Price
$936
Updated
2021/12/16
Tocris
Product number
1024
Product name
CGP20712dihydrochloride
Purity
≥96%(HPLC)
Packaging
10
Price
$227
Updated
2021/12/16
Usbiological
Product number
254932
Product name
CGP 20712 dihydrochloride
Packaging
10mg
Price
$480
Updated
2021/12/16
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CGP 20712 A Chemical Properties,Usage,Production

Uses

CGP-20712A methanesulfonate salt has been used as a β1-adrenergic receptor antagonist in adult rat ventricular myocytes (ARVM) and rat cardiac fibroblasts. It may also be used as an antagonist for the β1-adrenergic receptor in rat bladder smooth muscles.

Biological Activity

Highly selective and potent β 1 -adrenoceptor antagonist (IC 50 = 0.7 nM). Displays 10,000-fold selectivity over β 2 -adrenoceptors. Also available as part of the β -Adrenoceptor Antagonist Tocriset™ .

Biochem/physiol Actions

CGP-20712A methanesulfonate salt is a selective β1-adrenoceptor antagonist.

in vitro

In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors.

in vivo

Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection.

CGP 20712 A Preparation Products And Raw materials

Raw materials

Preparation Products

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CGP 20712 A Suppliers

China 14 Germany 2 South Korea 1 Switzerland 1 United Kingdom 1 United States 6 Global 25
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

105737-62-0, CGP 20712 A Related Search:

2-Methyl-4-trifluoromethylimidazole CGP 20712 A 1-(2-HYDROXY-ETHYLAMINO)-3-PHENOXY-PROPAN-2-OL 4-(Trifluoromethyl)-1H-imidazole 2-Phenyl-4-(trifluoromethyl)-1H-imidazole 2-(4-ETHOXY-PHENYL)-1H-IMIDAZOLE

  • CGP 20712A METHANESULFONATE SELECTIVE B1 ADRENOCE
  • 1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy)-2-propanoldihyd
  • CGP207122HCl
  • CGP-20712A methanesulfonate salt
  • (±)-2-Hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]phenoxy]propyl] amino]ethoxy]-benzamide methanesulfonate salt
  • 1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE
  • CGP 20712 DIHYDROCHLORIDE
  • (+/-)-1-(2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy)-2-propanol methane sulfonate
  • CGP 20712 mesylate
  • 1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazoyl)phenoxy]-2-propanol mesylate
  • CGP-20712A methanesulfonate salt solid, >=98% (HPLC)
  • 105737-62-0
  • C23H25F3N4O5CH4O3S
  • C24H27F3N4O7S
  • C23H25F3N4O52HCl
  • Adrenoceptor