CGP 20712 A
- Product Name
- CGP 20712 A
- CAS No.
- 105737-62-0
- Chemical Name
- CGP 20712 A
- Synonyms
- CGP207122HCl;CGP 20712 mesylate;CGP 20712 DIHYDROCHLORIDE;CGP-20712A methanesulfonate salt;CGP 20712A METHANESULFONATE SELECTIVE B1 ADRENOCE;CGP-20712A methanesulfonate salt solid, >=98% (HPLC);1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy)-2-propanoldihyd;1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazoyl)phenoxy]-2-propanol mesylate;1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE;(+/-)-1-(2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy)-2-propanol methane sulfonate
- CBNumber
- CB4380786
- Molecular Formula
- C24H29F3N4O8S
- Formula Weight
- 590.57
- MOL File
- 105737-62-0.mol
CGP 20712 A Property
- storage temp.
- 2-8°C
- solubility
- H2O: 10 mg/mL
- form
- solid
- color
- white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- C231
- Product name
- CGP-20712A methanesulfonate salt
- Purity
- solid, ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $195.6
- Updated
- 2024/03/01
- Product number
- C231
- Product name
- CGP-20712A methanesulfonate salt
- Purity
- solid, ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $1270
- Updated
- 2023/01/07
- Product number
- 1024
- Product name
- CGP20712dihydrochloride
- Purity
- ≥96%(HPLC)
- Packaging
- 50
- Price
- $936
- Updated
- 2021/12/16
- Product number
- 1024
- Product name
- CGP20712dihydrochloride
- Purity
- ≥96%(HPLC)
- Packaging
- 10
- Price
- $227
- Updated
- 2021/12/16
- Product number
- 254932
- Product name
- CGP 20712 dihydrochloride
- Packaging
- 10mg
- Price
- $480
- Updated
- 2021/12/16
CGP 20712 A Chemical Properties,Usage,Production
Uses
CGP-20712A methanesulfonate salt has been used as a β1-adrenergic receptor antagonist in adult rat ventricular myocytes (ARVM) and rat cardiac fibroblasts. It may also be used as an antagonist for the β1-adrenergic receptor in rat bladder smooth muscles.
Biological Activity
Highly selective and potent β 1 -adrenoceptor antagonist (IC 50 = 0.7 nM). Displays 10,000-fold selectivity over β 2 -adrenoceptors. Also available as part of the β -Adrenoceptor Antagonist Tocriset™ .
Biochem/physiol Actions
CGP-20712A methanesulfonate salt is a selective β1-adrenoceptor antagonist.
in vitro
In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors.
in vivo
Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection.