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PDDHV

Product Name
PDDHV
CAS No.
179469-40-0
Chemical Name
PDDHV
Synonyms
PDDHV;PHORBOL 12,13-DIDECANOATE 20-HOMOVANILLATE;Benzeneacetic acid, 4-hydroxy-3-methoxy-, [(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-1,1,6,8-tetramethyl-5-oxo-9,9a-bis[(1-oxodecyl)oxy]-1H-cyclopropa[3,4]benz[1,2-e]azulen-3-yl]methyl ester
CBNumber
CB4381723
Molecular Formula
C49H72O11
Formula Weight
837.09
MOL File
179469-40-0.mol
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PDDHV Property

storage temp. 
−20°C
solubility 
Methanol: soluble
form 
A solid
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Safety

Hazard Codes 
T+
Risk Statements 
26/27/28-36/37/38
Safety Statements 
26-27-36/37/39-45
RIDADR 
UN 2811 6.1/PG 2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
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N-Bromosuccinimide Price

Cayman Chemical
Product number
20445
Product name
PDDHV
Purity
≥99%
Packaging
1mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
20445
Product name
PDDHV
Purity
≥99%
Packaging
5mg
Price
$191
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008544
Product name
PHORBOL 12,13-DIDECANOATE 20-HOMOVANILLATE
Purity
95.00%
Packaging
1MG
Price
$151.2
Updated
2021/12/16
AK Scientific
Product number
9070CR
Product name
Pddhv
Packaging
1mg
Price
$160
Updated
2021/12/16
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PDDHV Chemical Properties,Usage,Production

Description

PDDHV is a resiniferatoxin-type phorboid vanilloid with capsaicin-like selectivity for the cloned rat transient receptor potential cation channel subfamily V member 1 (TRPV1), formerly known as vanilloid receptor 1. It induces Ca2+-uptake by rat dorsal root ganglion neurons with an EC50 value of 70 nM.

Uses

PDDHV is a calcium absorption inducer and may achieve 45Ca2+ influx by stimulating vanillic acid receptor VR1. PDDHV induces 45Ca2+ uptake (EC50: 70 nM) in rat dorsal root ganglion neurons (expressing native vanilloid receptors) and calcium mobilization (EC50: 125 nM) in VR1-transfected CHO cells. PDDHV also inhibits [3H]-resiniferatoxin (RTX) binding to the dorsal root ganglion membrane in rats[1].

References

[1] Szallasi A, Szabo T, Biro T, et al. Resiniferatoxin‐type phorboid vanilloids display capsaicin‐like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1[J]. British journal of pharmacology, 1999, 128(2): 428-434.

PDDHV Preparation Products And Raw materials

Raw materials

Preparation Products

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PDDHV Suppliers

China 21 Switzerland 3 United Kingdom 2 United States 3 Global 29
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87

179469-40-0, PDDHVRelated Search:

ALLYL PHENYLACETATE ETHYL HOMOVANILLATE 2,5-DIMETHYL-2-HEXENE-1,6-DIOL DIACETATE PHENYLACETIC ACID TRANS-2-HEXEN-1-YL ESTER PDDHV PHORBOL 12,13-DIDECANOATE PDNHV PHORBOL 12,13-DIACETATE ETHYL 3,4-DIHYDROXYPHENYLACETATE PHORBOL-12-DECANOATE PHORBOL-12,13-DIHEXANOATE PHORBOL 12,13-DIBUTYRATE PHORBOL 12,13,20-TRIACETATE, 4BETA phorbol-12,13-dipropionate PHORBOL 13,20-DIACETATE 1,2-Dimethyl-1,2-ethanediyl decanoate 12-deoxyphorbol-13-decanoate 12-O-acetylphorbol-13-decanoate

  • PHORBOL 12,13-DIDECANOATE 20-HOMOVANILLATE
  • PDDHV
  • Benzeneacetic acid, 4-hydroxy-3-methoxy-, [(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-1,1,6,8-tetramethyl-5-oxo-9,9a-bis[(1-oxodecyl)oxy]-1H-cyclopropa[3,4]benz[1,2-e]azulen-3-yl]methyl ester
  • 179469-40-0
  • C49H72O11