(S)-N-BOC-Propargylglycine

Product Name: (S)-N-BOC-Propargylglycine
CAS No.: 63039-48-5
Chemical Name: (S)-N-BOC-Propargylglycine
Synonyms: Boc-Pra-OH;BOC-L-PROPARGYLGLYCINE;RARECHEM BK PT 0256;Boc-propargyl-Gly-OH;Boc-Propargylglycine;Boc-Gly(propargyl)-OH;N-Boc-L-propargylglycine;Boc-propargyl-Gly-OH, 95%;(S)-N-BOC-PROPARGYLGLYCINE;Nα-Boc-propargyl-L-glycine
CBNumber: CB4393184
Molecular Formula: C10H15NO4
Formula Weight: 213.23
MOL File: 63039-48-5.mol

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(S)-N-BOC-Propargylglycine Property

Melting point:: 85.5 °C
Boiling point:: 353.22°C (rough estimate)
Density: 1.2177 (rough estimate)
refractive index: 1.4368 (estimate)
storage temp.: -20°C
pka: 3.53±0.10(Predicted)
form: Crystalline Powder
color: Off-white to light yellow
optical activity: [α]/D 26.0±2.0°, c = 1 in methanol
Water Solubility: Soluble in water.
BRN: 5739897
InChI: InChI=1S/C10H15NO4/c1-5-6-7(8(12)13)11-9(14)15-10(2,3)4/h1,7H,6H2,2-4H3,(H,11,14)(H,12,13)/t7-/m0/s1
InChIKey: AMKHAJIFPHJYMH-ZETCQYMHSA-N
SMILES: C(O)(=O)[C@@H](NC(OC(C)(C)C)=O)CC#C
CAS DataBase Reference: 63039-48-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H317May cause an allergic skin reaction
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 712221
Product name: Boc-propargyl-Gly-OH
Purity: ≥98.0% (HPLC)
Packaging: 500mg
Price: $215
Updated: 2025/07/31

TCI Chemical

Product number: B4007
Product name: N-(tert-Butoxycarbonyl)-L-propargylglycine
Purity: >97.0%(HPLC)(T)
Packaging: 1g
Price: $97
Updated: 2025/07/31

TRC

Product number: B663895
Product name: Boc-L-Propargylglycine
Packaging: 2.5g
Price: $150
Updated: 2021/12/16

TRC

Product number: B663895
Product name: Boc-L-Propargylglycine
Packaging: 1g
Price: $75
Updated: 2021/12/16

TRC

Product number: B663895
Product name: Boc-L-Propargylglycine
Packaging: 250mg
Price: $45
Updated: 2021/12/16

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(S)-N-BOC-Propargylglycine Chemical Properties,Usage,Production

Chemical Properties

off-white to light yellow crystalline powder

Uses

N-Boc-2-propargyl-L-glycine is used as pharmaceutical intermediate.

reaction suitability

reaction type: Boc solid-phase peptide synthesis
reaction type: click chemistry

Synthesis

24424-99-5

23235-01-0

61172-66-5

Step 5: Synthesis of Boc-L-ynylglycine L-alkynylglycine (10 g) [prepared according to Schwyzer et al. Helv. Chim. Acta, 59, 2181 (1976)] was suspended in tetrahydrofuran (30 mL). To this suspension, water (30 mL), potassium carbonate (36.7 g) and di-tert-butyl dicarbonate (21.9 g) were added sequentially. Subsequently, additional water was added to completely dissolve the mixture and the reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the organic solvent was removed by evaporation. The resulting aqueous solution was first washed with ether and then acidified with aqueous 1N citric acid to pH 3. The acidified solution was extracted with dichloromethane, and the extract was evaporated to remove the solvent to afford Boc-L-alkynylglycine (18.9 g, 97% yield), which was used in subsequent steps without further purification.

References

[1] Chemistry - An Asian Journal, 2010, vol. 5, # 8, p. 1765 - 1769
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 24, p. 7512 - 7515
[3] Patent: US5212185, 1993, A
[4] Patent: US5298505, 1994, A
[5] Patent: US5373017, 1994, A

(S)-N-BOC-Propargylglycine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-N-BOC-Propargylglycine Suppliers

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View Lastest Price from (S)-N-BOC-Propargylglycine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-propargyl-Gly-OH 63039-48-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-11-16

Henan Aochuang Chemical Co.,Ltd.

Product: (S)-N-BOC-Propargylglycine 63039-48-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-19

Career Henan Chemical Co

Product: (S)-N-BOC-Propargylglycine 63039-48-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-24

63039-48-5, (S)-N-BOC-PropargylglycineRelated Search:

L-Propargylglycine (R)-N-BOC-PROPARGYLGLYCINE,(R)-N-boc-Propargylglycine(e.e.),(R)-N-BOC-PROPARGYLGLYCINE, 95%, 98% EE,(R)-N-BOC-Propargylglycine, 98% ee (R)-METHYL-2-BOC-AMINO-4-PENTENOIC ACID D-PROPARGYLGLYCINE METHYL-2-BOC-AMINO-4-PENTENOIC ACID DL-PROPARGYLGLYCINE Boc-L-cyclopropylglycine CBZ-ALPHA-ALLYL-L-GLY D-Allylglycine CBZ-ALPHA-ALLYL-D-GLY (S)-2-(((benzyloxy)carbonyl)aMino)pent-4-ynoic acid (R)-2-(((benzyloxy)carbonyl)aMino)pent-4-ynoic acid 4-PENTYNOIC ACID Cyclohexylamine Glycine (S)-N-BOC-Propargylglycine BOC-L-PROPARGYLGLYCINE DCHA SALT BOC-(S)-ALPHA-PROPYNYL-PROLINE

BOC-L-PROPARGYLGLYCINE

(S)-N-(TERT-BUTOXYCARBONYL)-PROPARGYLGLYCINE

(S)-N-TERT-BUTOXYCARBONYL-2-AMINO-4-PENTYNOIC ACID

(S)-N-BOC-PROPARGYLGLYCINE

RARECHEM BK PT 0256

Boc-Gly(propargyl)-OH

(S)-N-Boc-propargylglycine(e.e.)

L-TERT-BUTOXYCARBONYL-L-PROPARGYL GLYCINE

BOC-2-PROPARGYL-L-GLYCINOL

N-BOC-2-PROPARGYL-L-GLYCINE

L-2-Propargylglycine, N-BOC protected

(S)-(1-Hydroxymethyl-but-3-ynyl)-carbamic acid tert-butyl ester

(S)-2-tert-Butoxycarbonylamino-pent-4-ynoic acid

Boc-Pra-OH

(2S)-2-(tert-butoxycarbonylamino)pent-4-ynoate

Boc-L-Propargylglycine.DCHA

(S)-N-Boc-propargylglycine, 95%, ee:98%

(S)-N-BOC-Propargylglycine, 98% ee

2-Propargyl-L-glycine, N-BOC protected 97%

SYNONYMS (S)-N-BOC-PROPARGYLGLYCINE

(2S)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-4-pentynoate

(Tert-Butoxy)Carbonyl Pra-OH

(S)-N-BOC-Propargylglycine,95%,98% ee

(S)-N-BOC-Propargylglycine(S)-N-tert-Butoxycarbonyl-2-amino-4-pentynoic acid

Boc-propargyl-Gly-OH

(2S)-2-[(tert-Butoxycarbonyl)amino]pent-4-ynoic acid

2-Propargyl-L-glycine, N-BOC protected

Boc-L-Propargylglycine Boc-L-Propargylglycine

Boc-Propargyl-Gly-OH, (S)-2-(Boc-aMino)-4-pentynoic acid

Nα-Boc-propargyl-L-glycine

(S)-2-Boc-AMino-4-pentynoic acid

N-(tert-Butoxycarbonyl)-L-propargylglycine

Boc-(S)-2-Propargylglycine

Boc-propargyl-Gly-OH >=98.0% (HPLC)

N-(tert-Butoxycarbonyl)-L-propargylglycine &gt

N-tert-Butoxycarbonyl-L-2-propargylglycine

Boc-Pra-OH Boc-Propargylglycine

4-Pentynoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (2S)-

(S)-2-(tert-Butoxycarbonylamino)-4-pentynoic Acid

N-Boc-L-propargylglycine

(S)-N-BOC-Propargylglycine USP/EP/BP

Boc-Propargylglycine

Boc-L-propargylglycine?DCHA - 1 g

Boc-propargyl-Gly-OH, 95%

63039-48-5

C10H14NO4

Unusual amino acids

Amino Acid Derivatives

Amino Acids