ChemicalBook > CAS DataBase List > 2,2,2-Trifluoroethylamine hydrochloride

2,2,2-Trifluoroethylamine hydrochloride

Product Name
2,2,2-Trifluoroethylamine hydrochloride
CAS No.
373-88-6
Chemical Name
2,2,2-Trifluoroethylamine hydrochloride
Synonyms
TAF;2,2,2-Trifluoroethanamine hydrochloride;TRIFLUOROETHYLAMINE HYDROCHLORIDE;2,2,2-Trifluoroethyla;2,2,2-TRIFLUORO-;2,2,2-TrifluoroethylamineHCl;2,2,2-Trifluoro-ethanamine HCl;trifluoro-ethylaminhydrochloride;2,2,2-Trifluoroaminehydrochloride;2,2,2-trifluoroethanaminium chloride
CBNumber
CB4396448
Molecular Formula
C2H5ClF3N
Formula Weight
135.52
MOL File
373-88-6.mol
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2,2,2-Trifluoroethylamine hydrochloride Property

Melting point:
220-222 °C (subl.)(lit.)
Density 
1,24g/cm
refractive index 
1,3-1,302
storage temp. 
Inert atmosphere,Room Temperature
form 
powder to crystal
color 
White to Light yellow to Light orange
Water Solubility 
It is Soluble in 0.7 to water, but soluble in ethanol and chloroform, slightly soluble in benzene, hardly soluble in ether.
Sensitive 
Hygroscopic
BRN 
3652103
InChI
InChI=1S/C2H4F3N.ClH/c3-2(4,5)1-6;/h1,6H2;1H
InChIKey
ZTUJDPKOHPKRMO-UHFFFAOYSA-N
SMILES
C(F)(F)(F)CN.Cl
CAS DataBase Reference
373-88-6(CAS DataBase Reference)
EPA Substance Registry System
Ethanamine, 2,2,2-trifluoro-, hydrochloride (373-88-6)
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Safety

Hazard Codes 
Xn,T,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
36/37-24/25-36-26
WGK Germany 
3
RTECS 
KS0250000
F 
3-10-21
Hazard Note 
Hygroscopic/Toxic
TSCA 
T
HazardClass 
IRRITANT
PackingGroup 
III
HS Code 
29211990
Toxicity
LD50 unr-mus: 476 mg/kg 11FYAN 3,81,63
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
180386
Product name
2,2,2-Trifluoroethylamine hydrochloride
Purity
98%
Packaging
10g
Price
$117.8
Updated
2025/07/31
Sigma-Aldrich
Product number
180386
Product name
2,2,2-Trifluoroethylamine hydrochloride
Purity
98%
Packaging
50g
Price
$271.7
Updated
2025/07/31
TCI Chemical
Product number
T1170
Product name
2,2,2-Trifluoroethylamine Hydrochloride
Purity
>98.0%(N)(T)
Packaging
5g
Price
$25
Updated
2025/07/31
TCI Chemical
Product number
T1170
Product name
2,2,2-Trifluoroethylamine Hydrochloride
Purity
>98.0%(N)(T)
Packaging
25g
Price
$64
Updated
2025/07/31
TRC
Product number
T787295
Product name
2,2,2-Trifluoroethylamine hydrochloride
Packaging
5g
Price
$100
Updated
2021/12/16
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2,2,2-Trifluoroethylamine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

WHITE TO LIGHT YELLOW CRYSTALLINE POWDER

Uses

2,2,2-Trifluoroethylamine Hydrochloride is a reagent in the synthesis of arachidonylethanolamide analogs. These show affinity for CB1 and CB2 cannabinoid receptors.

Safety Profile

Moderately toxic by unspecifiedroute. When heated to decomposition it emits very toxicfumes of F??, NOx, and HCl.

Synthesis

753-90-2

373-88-6

General procedure for the synthesis of 2,2,2-trifluoroethylamine hydrochloride from 2,2,2-trifluoroethylamine: 100 g of ethanol and 33 g of 2,2,2-trifluoroethylamine were added to a triple-necked flask, and 35 g of saturated hydrochloric acid solution was added slowly and dropwise at temperatures lower than 25°C. The reaction system was then brought up to 50°C and maintained there for 1 hour. After the dropwise addition, the temperature of the reaction system was raised to 50 °C and maintained for 1 hour. Subsequently, the temperature of the reaction solution was controlled to be 45±5°C under a vacuum of 0.98 MPa and a decompression distillation was carried out for 5 hours to remove water and ethanol. Finally 43.5 g of 2,2,2-trifluoroethylamine hydrochloride was obtained in 96.30% yield. The resulting product was a white powdery crystalline solid with 0.13% water.

References

[1] Patent: CN105801428, 2016, A. Location in patent: Paragraph 0016; 0017

2,2,2-Trifluoroethylamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,2,2-Trifluoroethylamine hydrochloride manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2,2,2-Trifluoroethylamine hydrochloride 373-88-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-11-26
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2,2,2-trifluoroethanaminium chloride 373-88-6
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-07-08
Hebei Fengjia New Material Co., Ltd
Product
2,2,2-Trifluoroethylamine hydrochloride 373-88-6
Price
US $30.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
100 tons
Release date
2024-08-09

373-88-6, 2,2,2-Trifluoroethylamine hydrochlorideRelated Search:

Triethylamine hydrochloride Topotecan hydrochloride Triethylamine 2-Phenylethylamine hydrochloride Ethylamine hydrochloride Trimethylamine hydrochloride 2,2,2-TRIFLUOROETHYLAMINE Perfluorotriethylamine Trifluoroacetamide Trifluoroacetonitrile Methanesulfonic acid, 1,1,1-trifluoro-, 5-hydroxy-1-naphthalenyl ester 2-AMINO-4,4,4-TRIFLUORO-N-BUTYRIC ACID HYDROCHLORIDE (3S)-(-)-3-(TRIFLUOROACETAMIDO)PYRROLIDINE HYDROCHLORIDE (S)-(-)-N-(TRIFLUOROACETYL)PROLYL CHLORIDE 2-[(3,4-DICHLOROBENZYL)SULFANYL]-3-METHYL-6-(TRIFLUOROMETHYL)-4(3H)-PYRIMIDINONE 4-chloro-2-[(2,2,2-trifluoroacetyl)amino]benzenecarboxylic acid 1-(4-CHLOROBENZYL)-2-OXO-6-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBOXAMIDE ETHYL 2-CHLORO-3,3,3-TRIFLUORO-2-ISOCYANATOPROPANOATE

  • 2,2,2-Trifluoroethyla
  • 2,2,2-trifluoroethan-1-aMine chloride
  • 2,2,2-trifluoroethanaminium chloride
  • 2,2,2-TrifluoroethylaMine Hydrochloride, 97+%
  • TAF
  • TRIFLUOROETHYLAMINE HYDROCHLORIDE
  • 2,2,2-TRIFLUOROETHYLAMINE HYDROCHLORIDE
  • 2,2,2-TRIFLUORO-ETHYL-AMMONIUM CHLORIDE
  • 2-AMINO-1,1,1-TRIFLUOROETHANE HYDROCHLORIDE
  • 2,2,2-trifluoro-ethanaminhydrochloride
  • trifluoro-ethylaminhydrochloride
  • 2,2,2-TrifluoroethylamineHCl
  • 2,2,2-Trifluoroethanamine hydrochloride
  • 2,2,2-TRIFLUORO-
  • 2,2,2-Trifluoroethylamine hydrochloride 98%
  • 2,2,2-Trifluoroethylaminehydrochloride98%
  • 2,2,2-Trifluoroethylamine hydrochloride(99%)
  • 2,2,2-Trifluoroethylamine hydrochloride ISO 9001：2015 REACH
  • 2,2,2-Trifluoroaminehydrochloride
  • Upadacitinib Impurity 61 Hydrochloride
  • 2,2,2-Trifluoro-ethanamine HCl
  • 373-88-6
  • 73-88-6
  • 206-58-2
  • C2H4F3NxHCL
  • C2H4F3NHCl
  • CF3CH2NH2HCl
  • C2H5ClF3N
  • C2H4F3NClH
  • Amine Salts
  • Building Blocks
  • Organic Building Blocks
  • Nitrogen Compounds