ChemicalBook > CAS DataBase List > 1-(4,6-dimethylpyrimidin-2-yl)-3-[2-(trifluoromethyl)phenyl]guanidine

1-(4,6-dimethylpyrimidin-2-yl)-3-[2-(trifluoromethyl)phenyl]guanidine

Product Name
1-(4,6-dimethylpyrimidin-2-yl)-3-[2-(trifluoromethyl)phenyl]guanidine
CAS No.
303094-67-9
Chemical Name
1-(4,6-dimethylpyrimidin-2-yl)-3-[2-(trifluoromethyl)phenyl]guanidine
Synonyms
ZINC69391;ZINC69391, 10 mM in DMSO;1-(4,6-dimethylpyrimidin-2-yl)-3-[2-(trifluoromethyl)phenyl]guanidine;N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine;Guanidine, N-(4,6-dimethyl-2-pyrimidinyl)-N'-[2-(trifluoromethyl)phenyl]-
CBNumber
CB43983665
Molecular Formula
C14H14F3N5
Formula Weight
309.29
MOL File
303094-67-9.mol
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1-(4,6-dimethylpyrimidin-2-yl)-3-[2-(trifluoromethyl)phenyl]guanidine Property

Melting point:
149-151 °C
Boiling point:
404.3±55.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 25 mg/mL (80.83 mM; ultrasonic and warming and heat to 60°C)
pka
4.69±0.70(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
Z701550
Product name
ZINC69391
Packaging
1mg
Price
$125
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0280250
Product name
1-(4,6-DIMETHYLPYRIMIDIN-2-YL)-3-[2-(TRIFLUOROMETHYL)PHENYL]GUANIDINE
Purity
95.00%
Packaging
5MG
Price
$499.05
Updated
2021/12/16
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1-(4,6-dimethylpyrimidin-2-yl)-3-[2-(trifluoromethyl)phenyl]guanidine Chemical Properties,Usage,Production

Uses

ZINC 69391 is a novel specific Rac1 inhibitor, interferring with the interaction of Rac1 with Dock180, a relevant Rac1 activator in glioma invasion, and to reduce Rac1-GTP levels.

in vivo

ZINC69391 (25 mg/kg; i.p; daily for 21 days) impairs metastatic lung colonization in a syngeneic animal model[3].

Animal Model:Specific pathogen-free female BALB/c inbred mice (bearing F3II cells)[3]
Dosage:25 mg/kg body weight
Administration:I.p; daily for 21 days
Result:Significantly reduced by about 60% the formation of total metastatic lung colonies.

1-(4,6-dimethylpyrimidin-2-yl)-3-[2-(trifluoromethyl)phenyl]guanidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4,6-dimethylpyrimidin-2-yl)-3-[2-(trifluoromethyl)phenyl]guanidine Suppliers

China 24 Finland 1 Russia 1 The Netherlands 1 United States 3 Global 30
Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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Shanghai Beckham Medical Technology Co., Ltd
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13816613772
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huahero21@sina.com
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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Shanghai SuperLan Chemcial Technique Centre
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TargetMol Chemicals Inc.
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Nanjing Shizhou Biology Technology Co.,Ltd
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RD International Technology Co., Limited
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Proteintech China
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303094-67-9, 1-(4,6-dimethylpyrimidin-2-yl)-3-[2-(trifluoromethyl)phenyl]guanidineRelated Search:

4-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonyl)-3-hydroxy-5-[4-(pentyloxy)phenyl]-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one ZINC03129319 (R)-ZINC-3573 ((R)-ZINC3573) 1-Pyrrolidinecarboxamide, 2-(4-methoxyphenyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]- 3,4-dihydro-1H-isoquinolin-2-yl-[3-(1H-indol-4-yl)-1,2,4-oxadiazol-5-yl]methanone 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(tetrahydro-2H-pyran-4-yl)- ZINC13466751 2-(2-oxobenzo[cd]indol-1(2H)-yl)-N-[2-(trifluoromethyl)phenyl]acetamide 6-(3,4-dimethoxyphenyl)-3-(2-thienyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 6-(3,4-dimethoxyphenyl)-3-(2-furyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

  • 1-(4,6-dimethylpyrimidin-2-yl)-3-[2-(trifluoromethyl)phenyl]guanidine
  • ZINC69391
  • Guanidine, N-(4,6-dimethyl-2-pyrimidinyl)-N'-[2-(trifluoromethyl)phenyl]-
  • N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine
  • ZINC69391, 10 mM in DMSO
  • 303094-67-9