1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

ChemicalBook > CAS DataBase List > 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

Product Name: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
CAS No.: 1892-57-5
Chemical Name: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
Synonyms: EDCI;EDAC;1-ETHYL-3-(3-DIMETHYLAMINOPROPYL) CARBODIIMIDE;WSCI;WSCD;N1-((EthyliMino)Methylene)-N3,N3-diMethylpropane-1,3-diaMine;1-(3-Dimethylaminopropyl)-3-;N-(3-DIMETHYLAMINOPROPYL)-N'-ETHYLCARBODIIMIDE;({[3-(dimethylamino)propyl]imino}methylidene)(ethyl)amine;WSC【Dotite】
CBNumber: CB4403030
Molecular Formula: C8H17N3
Formula Weight: 155.24
MOL File: 1892-57-5.mol

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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Property

Boiling point:: 66-68°C/1mm
Density: 0.877 g/mL at 20 °C (lit.)
refractive index: n20/D 1.461
Flash point:: 66-68°C/1mm
storage temp.: -20°C
solubility: Chloroform
pka: 9.52±0.28(Predicted)
form: Liquid
Specific Gravity: 0.885
color: Colorless to slightly yellow
Water Solubility: Soluble in water.
Sensitive: Air Sensitive
BRN: 507429
InChIKey: LMDZBCPBFSXMTL-UHFFFAOYSA-N
CAS DataBase Reference: 1892-57-5(CAS DataBase Reference)
NIST Chemistry Reference: 1,3-Propanediamine, n'-(ethylcarbonimidoyl)-n,n-dimethyl-(1892-57-5)
EPA Substance Registry System: 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl- (1892-57-5)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-36/37/39-45
RIDADR: UN 2735 8/PG 3
WGK Germany: 3
F: 1-3-10
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29252900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H317May cause an allergic skin reaction

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 39391
Product name: N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide
Purity: ≥97.0% (T)
Packaging: 10ml
Price: $185
Updated: 2024/03/01

Sigma-Aldrich

Product number: 39391
Product name: N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide
Purity: ≥97.0% (T)
Packaging: 50ml
Price: $798
Updated: 2024/03/01

TCI Chemical

Product number: D4029
Product name: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $80
Updated: 2024/03/01

TCI Chemical

Product number: D4029
Product name: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $240
Updated: 2024/03/01

Alfa Aesar

Product number: B25057
Product name: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 98%
Packaging: 5g
Price: $106
Updated: 2024/03/01

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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Chemical Properties,Usage,Production

Description

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is a water-soluble carbodiimide available as hydrochloride salt. This compound is a carboxyl- and amine-reactive crosslinker that is water soluble and can activate carboxyl residues for their reaction with primary amines to form O-acylisourea as a reaction intermediate, which reacts with amide bonds to release isourea as a by-product. It can crosslink the carboxy-group of glutamate and aspartate to the side-chain primary amine of lysine and the amino group at the N-terminus. The crosslinker readily reacts at a pH range of 4.5–7.2 and only crosslinks the residues within their van der Waals distance. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is also widely used in fabricating different nanosystems implemented in drug/protein delivery systems. It is mainly used for surface crosslinking/immobilization of drugs to increase stability against environmental changes, such as pH or temperature[1-2].

Chemical Properties

Clear light yellow liquid

Uses

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is used as a carboxyl activating agent and activate phosphate groups in phospho mono and di esters. It is used in peptide synthesis, 3'-amino-3'-deoxyadenosine-5'-di- and triphosphates and in the preparation of antibodies like immunoconjugates. It plays a vital role for immobilization of large biomolecules in association with N-hydroxysuccinimide. It is also used in the acylation of phosphoranes.

General Description

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide is commonly used in combination with N-hydroxysuccinimide (NHS) in carbodiimide coupling reaction to activate carboxyl group for coupling with amines to form amides.

Synthesis

The production method of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide is to react with N, N'-dimethylpropanediamine and carbon disulfide as raw materials to prepare N, N'- Dimethylpropylthiourea. Then it is oxidized with ethyl chloroformate to obtain N, N'-dimethylpropyl isothiocyanate, which is then reacted with ethylamine and oxidized with sodium hypochlorite to obtain the product 1-(3-dimethylaminopropyl)-3- Ethylcarbodiimide.

References

[1] Manjula ;Mummadisetti et al.“Chapter Five-An approach to nearest neighbor analysis of pigment-protein complexes using chemical cross-linking in combination with mass spectrometry.” Methods in enzymology" Methods in Enzymology, 680 (2023) 139-162.
[2] Dmour, Isra and M. Taha. “Natural and semisynthetic polymers in pharmaceutical nanotechnology.”Organic Materials as Smart Nanocarriers for Drug Delivery (2018) 35-100.

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Preparation Products And Raw materials

Raw materials

Ethyl isocyanate 3-Dimethylaminopropylamine Potassium carbonate Triethylamine Tosyl chloride Diethyl ether Dichloromethane

Preparation Products

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View Lastest Price from 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 1892-57-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-31

Hebei Weibang Biotechnology Co., Ltd

Product: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 1892-57-5
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-21

Hebei Yanxi Chemical Co., Ltd.

Product: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 1892-57-5
Price: US $30.00-9.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-10-25

1892-57-5, 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimideRelated Search:

ISOXADIFEN-ETHYL N,N'-Diisopropylcarbodiimide 4-Dimethylaminobenzoic acid Ethylparaben Ethyl acetate Ethyl acrylate Ethanol N,N-Diisopropylethylamine Cyanamide Lithium diisopropylamide 4-Dimethylaminopyridine N,N-Dimethylallylamine Ethyl pyruvate Ethyl formate N,N-Dimethylformamide O-Phthalimide Ethyl cyanoacetate 4-Dimethylaminobenzaldehyde

1-ETHYL-3-(3-DIMETHYLAMINOPROPYL) CARBODIIMIDE

1-(3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE

WATER-SOLUBLE CARBODIIMIDE

WSCD

WSCI

N-ETHYL-N'-(3-DIMETHYLAMINOPROPYL)CARBODIIMIDE

N-(3-DIMETHYLAMINOPROPYL)-N'-ETHYLCARBODIIMIDE

[3-(Dimethylamino)propyl]ethylcarbodiimide

ethyldimethylaminopropylcarbodiimide

n’-(ethylcarbonimidoyl)-n,n-dimethyl-3-propanediamine

N3-Ethyliminomethylene-N1,N1-dimethylpropane-1,3-diamine

1-(3-dimethylaminopropyl)-N?ethylcarbodiimide

N'-(ethylcarbonimidoyl)-N,N-dimethylpropane-1,3-diamine

EDAC

EDCI

Rivaroxaban Impurity 139

N'-(Ethylkohlenstoffimidoyl)-N,N-dimethylpropan-1,3-diamin

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 98%

EDC polymer-bound, N-Ethyl-Nμ-(3-dimethylaminopropyl)carbodiimide polymer-bound, N-(3-Dimethylaminopropyl)-Nμ-ethylcarbodiimide polymer-bound

EDC, WSC, N-Ethyl-Nμ-(3-dimethylaminopropyl)carbodiimide

1-ehyl-3-(dimethylaminopropyl)carbodiimide

3-[(Ethylcarbonimidoyl)amino]-N,N-dimethyl-1-propanamine

WSC【Dotite】

3-(ethyliminomethyleneamino)propyl-dimethyl-amine

3-(ethyliminomethylideneamino)-N,N-dimethyl-propan-1-amine

3-(ethyliminomethylideneamino)-N,N-dimethylpropan-1-amine

N-(3-Dimethylaminopr

N-(3-DiMethylaMinopropyl)-N'-ethylcarb

N-(3-DiMethylaMinopropyl)-N'-ethylcarbodiiMide(EDCI)

N-(3-DiMethylaMinopropyl)-N'-ethylcarbodiiMide >=97.0% (T)

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide EDC EDAC

N1-((EthyliMino)Methylene)-N3,N3-diMethylpropane-1,3-diaMine

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide(EDC)

({[3-(dimethylamino)propyl]imino}methylidene)(ethyl)amine

1-(3-Dimethylaminopropyl)-3-

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 97%, for synthesis

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide&gt

1,3-Propanediamine, N3-(ethylcarbonimidoyl)-N1,N1-dimethyl-

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide, ≥97%

Avanafil Impurity 72

1-ETHYL-(3- DIMETHYLAMINOPROPYL)CARBODIIMIDE (EDC Free Base)

1-(3-Dimethylaminopropyl)-3- ethylcarb

n'-(ethylkohlenstoffimidoyl)-n,n-dimethylpropan-1,3-diamin

N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide

1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide

1892-57-5

25952-83-0

CH3CH2NCNCH23NCH32

C8H17N3

BioChemical

Carbodiimides

Reagents for Protein Sequencing

Protein Sequencing

Protein Analysis

Proteomics and Protein Expression

Synthetic Reagents

Coupling

straight chain compounds