4-(2-Aminoethyl)morpholine Property

Melting point:

24 °C

Boiling point:

205 °C(lit.)

Density 

0.992 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.476(lit.)

Flash point:

347 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Chloroform, Methanol

form 

Liquid After Melting

pka

pK1: 4.06(+2);pK2: 9.15(+1) (25°C)

color 

Clear colorless to pale yellow

Water Solubility 

soluble

Sensitive 

Air Sensitive

BRN 

104378

Stability:

Air Sensitive

InChIKey

RWIVICVCHVMHMU-UHFFFAOYSA-N

CAS DataBase Reference

2038-03-1(CAS DataBase Reference)

NIST Chemistry Reference

4-Morpholineethanamine(2038-03-1)

EPA Substance Registry System

4-Morpholineethanamine (2038-03-1)

Safety

Hazard Codes 

C,T

Risk Statements 

22-34-43-24-40-23/24/25

Safety Statements 

26-36/37/39-45-22

RIDADR 

UN 2735 8/PG 2

WGK Germany 

2

RTECS 

QD7350000

Hazard Note 

Toxic

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29349990

Toxicity

guinea pig,LD50,skin,300uL/kg (0.3mL/kg),Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 269, 1944.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

4-(2-Aminoethyl)morpholine Chemical Properties,Usage,Production

Chemical Properties

clear colorless to pale yellow liq. after melting

Uses

4-(2-Aminoethyl)morpholine is used as a ligand and reacts with nickel(II) nitrite to form trans-bis[4-(2-aminoethyl)morpholine]dinitronickel(II).

Uses

4-(2-Aminoethyl)morpholine is widely used in biomedical applications as this moiety serves as an important lysosome-targeting group. Some of its applications include:

• Synthesis of the lysosome-targetable fluorescent probe for hydrogen sulfide imaging in living cells.
• Synthesis of 1,8-naphthalimide conjugated Troger′s bases as deoxyribonucleic acid (DNA) targeting fluorescent probe.
• Synthesis of intramolecular charge transfer-photoinduced electron transfer-fluorescence resonance energy transfer (ICT-PET-FRET) fluorescent probe for monitoring pH changes in living cells.
• It is also used as a precursor to synthesize a variety of antimicrobial agents.

Definition

ChEBI: 4-2-Aminoethyl-morpholine is a member of morpholines.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 34, p. 1805, 1991 DOI: 10.1021/jm00110a008