2-Hydroxyphenylboronic acid
- Product Name
- 2-Hydroxyphenylboronic acid
- CAS No.
- 89466-08-0
- Chemical Name
- 2-Hydroxyphenylboronic acid
- Synonyms
- AKOS BRN-0196;2-Boronophenol;RARECHEM AH PB 0223;2-Hydroxyphenylboronic;2-Hydroxybenzeneboronic;Hydroxyphenylboronic Aci;2-hydroxyphenylboric acid;2-HYDROXYPHENYLBORONIC ACID;O-HYDROXYPHENYLBORONIC ACID;2-HYDROXYBENZENEBORONIC ACID
- CBNumber
- CB4412001
- Molecular Formula
- C6H7BO3
- Formula Weight
- 137.93
- MOL File
- 89466-08-0.mol
2-Hydroxyphenylboronic acid Property
- Melting point:
- 178-182°C
- Boiling point:
- 327.3±44.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Acetonitrle (Slightly), DMSO (Slightly)
- pka
- 8.61±0.58(Predicted)
- form
- Powder
- color
- White
- Water Solubility
- Insoluble in water.
- BRN
- 2962938
- InChI
- InChI=1S/C6H7BO3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8-10H
- InChIKey
- YDMRDHQUQIVWBE-UHFFFAOYSA-N
- SMILES
- B(C1=CC=CC=C1O)(O)O
- CAS DataBase Reference
- 89466-08-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-41-22
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 29319000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CDS000901
- Product name
- 2-Hydroxyphenylboronic acid
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 250 mg
- Price
- $107
- Updated
- 2025/07/31
- Product number
- H1184
- Product name
- 2-Hydroxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $64
- Updated
- 2025/07/31
- Product number
- H1184
- Product name
- 2-Hydroxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $194
- Updated
- 2025/07/31
- Product number
- H952913
- Product name
- 2-Hydroxyphenylboronicacid
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- H952913
- Product name
- 2-Hydroxyphenylboronicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
2-Hydroxyphenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
2-Hydroxyphenylboronic acid combines the aromaticity of the benzene ring with the special properties of boric acid in its structure, forming a unique molecular structure.
Uses
suzuki reaction
Uses
2-Hydroxybenzeneboronic acid is used as a pharmaceutical intermediate.
Synthesis
1034050-50-4
89466-08-0
General procedure for the synthesis of 2-hydroxyphenylboronic acid from 2-methoxyphenylboronic acid: 1.5 kg of 2-methoxyphenylboronic acid was added to a 30 L glass reactor under nitrogen protection, followed by 18 L of anisole and 1.56 kg of acetyl chloride. After the addition was completed, the reaction mixture was cooled to -10 to 0 °C and stirred at this temperature for 1 hour. Then, 133 g of anhydrous aluminum trichloride was added in batches. After the addition was completed, the reaction mixture was allowed to warm up naturally to room temperature and stirred continuously until the TLC detection showed that the reaction of the raw material was complete, a process that usually takes 8 to 10 hours. During the reaction, the solids in the reaction mixture were first gradually dissolved, followed by gradual precipitation of solids. Upon completion of the reaction, the reaction was quenched with 5 M aqueous potassium hydroxide and the pH was adjusted to 11 to 12. The organic layer was separated and discarded. The pH was adjusted to 2~3 by adding 6 M aqueous hydrochloric acid to the aqueous layer and then extracted twice with 12 L ethyl acetate, the organic layers were combined and washed with saturated brine. The organic layer was rotary evaporated to dryness and finally pulped with acetone/n-heptane to give 1.06 kg of 2-hydroxyphenylboronic acid in 77% yield and 98.6% HPLC purity.
References
[1] Patent: CN104788483, 2017, B. Location in patent: Paragraph 0018; 0019; 0020
2-Hydroxyphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Hydroxyphenylboronic acid Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
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- Country
- Japan
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View Lastest Price from 2-Hydroxyphenylboronic acid manufacturers
- Product
- 2-Hydroxyphenylboronic acid 89466-08-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25
- Product
- 2-Hydroxyphenylboronic acid 89466-08-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19
- Product
- 2-Hydroxyphenylboronic acid 89466-08-0
- Price
- US $40.00-2.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-09-27