ChemicalBook > CAS DataBase List > L-Lactide

L-Lactide

Product Name
L-Lactide
CAS No.
4511-42-6
Chemical Name
L-Lactide
Synonyms
LACTIDE;L-LA;L-(-)-LACTIDE;LL-Lactide;L,L-Dilactide;(3S)-CIS-3,6-DIMETHYL-1,4-DIOXANE-2,5-DIONE;actide;-(-)-L;(3S,6S);L-LACTIDE
CBNumber
CB4416791
Molecular Formula
C6H8O4
Formula Weight
144.13
MOL File
4511-42-6.mol
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L-Lactide Property

Melting point:
92-94 °C(lit.)
Boiling point:
255°C
Density 
1.186±0.06 g/cm3(Predicted)
vapor pressure 
0.311Pa at 25℃
refractive index 
1.4475
storage temp. 
2-8°C
solubility 
Soluble in chloroform, and methanol. Slightly soluble in benzene.
form 
Solid
color 
White to Off-White
optical activity
[α]20/D 285°, c = 1 in toluene
Water Solubility 
16.7g/L at 20℃
Sensitive 
Moisture Sensitive
BRN 
82124
Stability:
Hygroscopic
InChIKey
JJTUDXZGHPGLLC-IMJSIDKUSA-N
LogP
0.4 at 25℃
CAS DataBase Reference
4511-42-6(CAS DataBase Reference)
EPA Substance Registry System
1,4-Dioxane-2,5-dione, 3,6-dimethyl-, (3S,6S)- (4511-42-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36
Safety Statements 
26-37/39
WGK Germany 
3
TSCA 
Yes
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
367044
Product name
(3S)-cis-3,6-Dimethyl-1,4-dioxane-2,5-dione
Purity
98%
Packaging
25g
Price
$88.1
Updated
2024/03/01
Sigma-Aldrich
Product number
367044
Product name
(3S)-cis-3,6-Dimethyl-1,4-dioxane-2,5-dione
Purity
98%
Packaging
100g
Price
$307
Updated
2024/03/01
TCI Chemical
Product number
L0115
Product name
L-(-)-Lactide
Purity
>98.0%(T)
Packaging
25g
Price
$93
Updated
2024/03/01
TCI Chemical
Product number
L0115
Product name
L-(-)-Lactide
Purity
>98.0%(T)
Packaging
250g
Price
$557
Updated
2024/03/01
Alfa Aesar
Product number
L09031
Product name
L-Lactide, 98+%
Packaging
5g
Price
$27.65
Updated
2024/03/01
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L-Lactide Chemical Properties,Usage,Production

Description

L-lactide (3,6-dimethyl-1,4-dioxane-2,5-dione) is a cyclic lactone that is derived from lactic acid. It has the molecular formula C3H6O2 and is an essential building block for synthesizing polylactic acid (PLA) plastics, which are widely used in the manufacturing industry.

Chemical Properties

White crystal

Uses

(3S)-cis-3,6-Dimethyl-1,4-dioxane-2,5-dione may be used in the synthesis of optically active terpyridine containing poly(L-lactide)s, polydisperse lactic acid oligomers, bicyclic and tricyclic lactide derivatives.

Application

L-Lactide is a monomer used to produce polylactic acid (PLA), which is a biodegradable thermoplastic that has many uses in the pharmaceutical industry. Additionally, L-Lactide can be used to modify existing drug carriers or create new ones from scratch. As such, the pharmaceutical industry relies heavily on L-Lactide for its versatile applications.

Flammability and Explosibility

Non flammable

Purification Methods

This is the cyclic dilactone of lactic acid. The (±)-cis-racemate has been distilled with b 142o/8mm; the distillate which solidifies gives yellow needles on recrystallisation from EtOH with m 128o, from Et2O with m 129o, or CHCl3 with m 126o , 1720-1740 cm-1. It hydrolyses in cold max H2O. [Carothers et al. J Am Chem Soc 54 772 1932]. A trans-form (probably RS,SR) has been reported which crystallises from Et2O with m 42-43o [Hummel et al. Acta Cryst (Sect B) 38 1679 1982]. The R,R -(+)-lactide has b 150o/2mm and crystallises from Et2O with m 95o , or m 96.5 -97.5o (from CHCl3) or m 97.7o (from EtOAc) and [] D +297o (c 1.2, *C6H6). The S,S-(-)-lactide has b 150o/2.5mm and crystallises from EtOAc with m 98.7o, or m 95o (from CHCl3) or m 96.5-97.5o (from CCl4) and []D -297o (c 1.2, *C6H6). [Toniolo et al. J Org Chem 35 6 1970, Beilstein 19 H 154, 19 I 179, 19 II 176, 19 IV 1927, 19/5 V 10.]

L-Lactide Preparation Products And Raw materials

Raw materials

Preparation Products

Ethyl lactate Butyl lactate
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View Lastest Price from L-Lactide manufacturers

Hebei Longbang Technology Co., Ltd
Product
L-Lactide 4511-42-6
Price
US $6.00/kg
Min. Order
1kg
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-05-27
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
L-Lactide 4511-42-6
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-08
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
L-(-)-Lactide 4511-42-6
Price
US $70.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-06-04

4511-42-6, L-LactideRelated Search:

Dimethyl carbonate Cyclohexane ETHANE Dimethyl sulfoxide Hexane Dimethyl fumarate Dimethyl ether N,N-Dimethylformamide Cyclohexene oxide Methylcyclohexane 1,4-Dioxane L-Homoserine lactone hydrochloride POLY(D,L-LACTIDE-CO-GLYCOLIDE) LACTIDE(D,L-),DL-LACTIDE,LACTIDE 2-hydroxypropionicacid,isopropylester 1,4-Dioxane-2,5-dione (S)-(-)-2-ACETOXYPROPIONIC ACID ETHYL (S)-(-)-2-METHOXYPROPIONATE

  • L-3,6-Dimethyl-1,4-dioxane-2,5-dione
  • 1,4-Dioxane-2,5-dione, 3,6-dimethyl-, (3S,6S)-
  • 3,6-dimethyl-1,4-dioxane-2,5-quinone
  • actide
  • L-(-)-LACTIDE 98+%
  • 3,6-Dimethyl-2,5-p-dioxanedione
  • L-(-)-Lactide ,99%
  • L,L-Dilactide
  • L-3,6-DiMethyl-p-dioxane-2,5-dione
  • LL-Lactide
  • L-(-)-Dilactide (3S,6S)-(-)-3,6-Dimethyl-1,4-dioxane-2,5-dione
  • L(-)-Lactide USP
  • (3S)-cis-3,6-DiMethyl-1,4-dioxane-2,5-dione 98%
  • <small>L</small>-(-)-Lactide
  • (3S,6S)
  • (3S)-CIS-3,6-DIMETHYL-1,4-DIOXANE-2,5-DIONE
  • (3S,6S)-(-)-3,6-DIMETHYL-1,4-DIOXANE-2,5-DIONE
  • L-LACTIDE S
  • L-(-)-LACTIDE
  • L-LACTIDE
  • LACTIDE
  • LACTIDE(L-)
  • L-(-)-DILACTIDE
  • PURASORB(R) L
  • 5-dione,3,6-dimethyl-,(3s,6s)-4-dioxane-2
  • (S,S)-3,6-Dimethyl-1,4-dioxane-2,5-dione
  • L-LA
  • L-(-)-Lactide&gt
  • L-(-)-Dilactide,99%+
  • (3S-cis)-3,6-Dimethyl-1,4-dioxan-2,5-dion
  • -(-)-L
  • Biomaterial Intermediate Monomer L-Lactide (LLA) CAS No.:?4511-42-6
  • Polyhexamethyleneguanidine hydrochloride 57028-96-3
  • L-lactide/L-lactide (with details)
  • Aaron chemistry
  • 4511-42-6
  • 4551-42-6
  • Asymmetric Synthesis
  • Glycidyl Compounds, etc. (Chiral)
  • Lactones & Lactides (for High-Performance Polymer Research)
  • Dioxanes
  • Chiral Building Blocks
  • Dioxanes & Dioxolanes
  • Reagent for High-Performance Polymer Research
  • Organic Building Blocks
  • Lactones
  • Chiral Building Blocks
  • Dioxanes
  • Dioxanes & Dioxolanes
  • Functional Materials
  • Glycidyl Compounds, etc. (Chiral)
  • Lactones & Lactides (for High-Performance Polymer Research)
  • Reagent for High-Performance Polymer Research
  • Synthetic Organic Chemistry
  • 4511-42-6