ChemicalBook > CAS DataBase List > β-Boswellic Acid

β-Boswellic Acid

Product Name: β-Boswellic Acid
CAS No.: 631-69-6
Chemical Name: β-Boswellic Acid
Synonyms: BRN0077366;Masticinic acid;Frankincic acid;B-BOSWELLIC ACID;β-Boswellic Acid;BOSWELLIC ACID, B-;BETA-BOSWELLIC ACID;BOSWELLIC ACID, a-(P);BOSWELLIC ACID B-(P) 25mg;β-Boswellic Acid USP/EP/BP
CBNumber: CB4427357
Molecular Formula: C30H48O3
Formula Weight: 456.71
MOL File: 631-69-6.mol

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β-Boswellic Acid Property

Melting point:: 130-135°C
alpha: D +107° (c = 0.75 in CHCl3)
Boiling point:: 556.0±50.0 °C(Predicted)
Density: 1.09±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: Solid
pka: 4.50±0.70(Predicted)
color: Off-White
Water Solubility: practically insoluble in water
InChIKey: NBGQZFQREPIKMG-AKOQEMLPSA-N
LogP: 9.105 (est)
CAS DataBase Reference: 631-69-6

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89454
Product name: β-Boswellic acid
Purity: phyproof<SUP>®</SUP> Reference Substance
Packaging: 10 mg
Price: $618
Updated: 2025/07/31

Sigma-Aldrich

Product number: 80342
Product name: β-Boswellic acid
Purity: analytical standard
Packaging: 5mg
Price: $578
Updated: 2025/07/31

Cayman Chemical

Product number: 11693
Product name: β-Boswellic Acid
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 11693
Product name: β-Boswellic Acid
Purity: ≥95%
Packaging: 5mg
Price: $183
Updated: 2024/03/01

Cayman Chemical

Product number: 11693
Product name: β-Boswellic Acid
Purity: ≥95%
Packaging: 10mg
Price: $321
Updated: 2024/03/01

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β-Boswellic Acid Chemical Properties,Usage,Production

Description

β-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities. It inhibits 5-lipoxygenase (5-LO) with an IC₅₀ value of approximately 5 μM but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid . It inhibits cell proliferation in HL-60 cells with IC₅₀ values of 3.7, 7.1, and 6.3 μM for DNA, RNA, and protein synthesis, respectively. In human umbilical vein endothelial cells (HUVECs) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS). It also increases calcium mobilization in platelets at concentrations ≥3 μM and induces platelet aggregation (EC₅₀ = 8 μM).

Chemical Properties

BETA-BOSWELLIC ACID is Off-White Solid

Uses

The principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation.

Definition

ChEBI: Boswellic acid is a triterpenoid.

Anticancer Research

It is a natural pentacyclic triterpenediol and occurs in Boswellia serrata plants as anisomeric blend of 3α, 24-dihydroxyolean-12-ene and 3α, 24-dihydroxyurs-12-ene.It induces apoptosis in various cancer cells. The events involved in this process areexcessive reactive oxygen species (ROS), nitric oxide (NO) formation, DNA ladderformation, and increased sub-G0 phase in cell cycle. This ultimately results incleavage of Bcl-2 and translocation of Bax to mitochondria, which lead to the lossof mitochondrial potential and release of cyt-c and other factors into cytosol. All these events are linked with reduced expression of survivin and inhibitor of caspase-activatedDNases (ICAD) that leads to the activation of poly(ADP-ribose) polymerase(PARP). The triterpene upregulates the expression of cell death receptor-4(DR-4) and tumor necrosis factor receptor-1 (TNF-R1), where both lead to activationof caspase-8 (Huang et al. 2000; Desai et al. 2008; Lu et al. 2008).

References

[1] H.P.T. AMMON. Mechanism of antiinflammatory actions of curcumine and boswellic acids[J]. Journal of ethnopharmacology, 1993, 38 2: Pages 105-112. DOI: 10.1016/0378-8741(93)90005-p
[2] H SAFAYHI. Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.[J]. Journal of Pharmacology and Experimental Therapeutics, 1992, 261 3: 1143-1146.
[3] Y SHAO. Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture.[J]. Planta medica, 1998, 64 4: 328-331. DOI: 10.1055/s-2006-957444
[4] MINGMING WANG. Pretreatment with β-Boswellic Acid Improves Blood Stasis Induced Endothelial Dysfunction: Role of eNOS Activation.[J]. Scientific Reports, 2015: 15357. DOI: 10.1038/srep15357
[5] ULF SIEMONEIT. Defined Structure-Activity Relationships of Boswellic Acids Determine Modulation of Ca2+ Mobilization and Aggregation of Human Platelets by Boswellia serrata Extracts.[J]. Planta medica, 2017, 83 12-13: 1020-1027. DOI: 10.1055/s-0043-107884

β-Boswellic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from β-Boswellic Acid manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: β-Boswellic Acid 631-69-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: >99% HPLC
Supply Ability: 1000KG
Release date: 2022-09-22

Hebei Zhuanglai Chemical Trading Co Ltd

Product: β-Boswellic Acid 631-69-6
Price: US $79.00-38.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-11-21

Hebei Chuanghai Biotechnology Co., Ltd

Product: β-Boswellic Acid 631-69-6
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

631-69-6, β-Boswellic AcidRelated Search:

Carbenoxolone OLIBANUM GUM β-Elemonic Acid (3alpha,4beta)-3-(Acetyloxy)olean-12-en-23-oic acid BOSWELLIC ACID, B-(P) ACETYL-B-BOSWELLIC ACID, 3-(P) ACETYL-A-BOSWELLIC ACID, 3-(P) ALPHA-BOSWELLIC ACID 11-KETO-BETA-BOSWELLIC ACID 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID,3-O-ACETYL-11-KETO-BETA-BOSWELLIC ACID,ACETYL-11-KETO-BETA-BOSWELLIC ACID BETA-BOSWELLIC ACID BRASSIDIC ACID 3-ACETYL-BETA-BOSWELLIC ACID URS-12(13)-ENE Erucic Acid

BETA-BOSWELLIC ACID

B-BOSWELLIC ACID

BOSWELLIC ACID, B-

Beta-BoswellicAcidforU.Lingner-HoffmannCHEMOSGmbHsales

(3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bR)-3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picene-4-carboxylic acid

BOSWELLIC ACID, a-(P)

(3A,4B)-3-HYDROXYURS-12-EN-23-OIC ACID

(3a,4)-3-Hydroxyurs-12-en-23-oic Acid

(3α,4β)-3-Hydroxyurs-12-en-23-oic Acid

3-Hydroxy-12-ursen-24-oic acid

3α-Hydroxyurs-12-en-24-oic acid

NBGQZFQREPIKMG-PONOSELZSA-N

Soluble BOSWELLIC ACID, Liposomal BOSWELLIC ACID, BOSWELLIC ACID NanoEmulsion, NanoActive BOSWELLIC ACID, BETA-BOSWELLIC ACID,Boswellia sacra

Soluble BOSWELLIC ACID, Liposomal BOSWELLIC ACID, BOSWELLIC ACID NanoEmulsion, NanoActive BOSWELLIC ACID, BETA-BOSWELLIC ACID

Urs-12-en-23-oic acid, 3-hydroxy-, (3α,4β)-

β-Boswellic Acid USP/EP/BP

Masticinic acid

BRN0077366

β-Boswellic Acid

BOSWELLIC ACID B-(P) 25mg

Frankincic acid

β-Boswellic acid, 10 mM in DMSO

Nano-Liposome BOSWELLIA SERRATA EXTRACT

Water-Soluble BOSWELLIA SERRATA EXTRACT

631-69-6

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