2-CHLORO-5-PHENYL-PYRIMIDINE

Application

Product Name: 2-CHLORO-5-PHENYL-PYRIMIDINE
CAS No.: 22536-62-5
Chemical Name: 2-CHLORO-5-PHENYL-PYRIMIDINE
Synonyms: 2-Chloro-5-phenyl-pyridimine;2-CHLORO-5-PHENYL-PYRIMIDINE;PyriMidine,2-chloro-5-phenyl-;2-CHLORO-5-PHENYL-PYRIMIDINE ISO 9001：2015 REACH
CBNumber: CB4428455
Molecular Formula: C10H7ClN2
Formula Weight: 190.63
MOL File: 22536-62-5.mol

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2-CHLORO-5-PHENYL-PYRIMIDINE Property

Melting point:: 131-133 °C
Boiling point:: 369.9±21.0 °C(Predicted)
Density: 1.245±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.71±0.22(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B428563
Product name: 2-chloro-5-phenylpyrimidine
Packaging: 50mg
Price: $110
Updated: 2021/12/16

Apolloscientific

Product number: OR938765
Product name: 2-Chloro-5-phenylpyrimidine
Purity: 95%
Packaging: 250mg
Price: $327
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: NUC0001548
Product name: 2-CHLORO-5-PHENYL-PYRIMIDINE
Purity: 95.00%
Packaging: 5MG
Price: $501.88
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-5-MX
Product name: 2-Chloro-5-phenylpyrimidine
Purity: 95%
Packaging: 1g
Price: $888
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-5-MX
Product name: 2-Chloro-5-phenylpyrimidine
Purity: 95%
Packaging: 250mg
Price: $360
Updated: 2021/12/16

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2-CHLORO-5-PHENYL-PYRIMIDINE Chemical Properties,Usage,Production

Application

2-Chloro-5-phenylpyrimidine can be used as an organic synthesis intermediate. It can be prepared by reacting 5-bromo-2-chloropyrimidine with Ph3In as a reactant, or by reacting 5-bromo-2-chloropyrimidine with phenylboronic acid via the Suzuki reaction.

Synthesis

32779-36-5

98-80-6

22536-62-5

General procedure: 5-bromo-2-chloropyrimidine (1 eq.), phenylboronic acid (1.1 eq.), Na2CO3 (1.1 eq.) and H2O (5 mL) were added to a round bottom flask, followed by catalyst (2 mol%). The reaction mixture was stirred at 45 °C until the reaction was complete. Upon completion of the reaction, the reaction mixture was diluted with water and the product was extracted with ethyl acetate. The ethyl acetate extract was filtered through a bed of diatomaceous earth and subsequently analyzed by GC. Retention times were verified using standards of 5-bromo-2-chloropyrimidine and 2-chloro-5-phenylpyrimidine to confirm product generation. The ethyl acetate extract was concentrated and purified by silica gel column chromatography using a solvent mixture of hexane and ethyl acetate as eluent to give 2-chloro-5-phenylpyrimidine. The product was characterized by NMR, GC-MS and UPLC analysis.

References

[1] Journal of Heterocyclic Chemistry, 2008, vol. 45, # 4, p. 1077 - 1081
[2] Journal of Molecular Catalysis A: Chemical, 2013, vol. 371, p. 118 - 124
[3] European Journal of Medicinal Chemistry, 2018, vol. 150, p. 30 - 38
[4] Patent: WO2004/22556, 2004, A1. Location in patent: Page 16-17

2-CHLORO-5-PHENYL-PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-5-PHENYL-PYRIMIDINE Suppliers

China 53 India 1 United States 7 Global 61

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Tetranov Biopharm

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Country: China
ProdList: 7892
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
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Nanjing Vital Chemical Co., Ltd.

Tel: Please Send Email 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
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Wuhan ariel chemical Co., LTD.

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Fax: 027-87840182
Email: sales@3stc.com
Country: China
ProdList: 3764
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Nanjing Norris-Pharm Technology Co., Ltd

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Email: sales@norris-pharm.com
Country: China
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Shanghai Jian Chao Chemical Technology Co., Ltd.

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Wuhan Kaymke Chemical Co., Ltd.,

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Bide Pharmatech Ltd.

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Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
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View Lastest Price from 2-CHLORO-5-PHENYL-PYRIMIDINE manufacturers

Dideu Industries Group Limited

Product: 2-CHLORO-5-PHENYL-PYRIMIDINE 22536-62-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-17

Career Henan Chemical Co

Product: 2-CHLORO-5-PHENYL-PYRIMIDINE 22536-62-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-08

22536-62-5, 2-CHLORO-5-PHENYL-PYRIMIDINERelated Search:

2-Chloro-4-(Trifluoromethoxy)Bromobenzene 2'-Chloro-4'-hydroxyacetophenone 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE 2-Chloro-5-ethylpyrimidine 2-CHLORO-3-FLUOROPHENOL 2-Chloro-3,5-dibromo-4-methylpyridine 2-CHLORO-6-FLUOROPYRIDINE 2-Chloro-8-isopentyl-7-methyl-7,8-dihydropteridin-6(5H)-one 2-CHLORO-5-(4-METHOXYPHENYL)PYRIMIDINE 2-CHLORO-5-PHENYL-PYRIMIDINE 2-chloro-N,N-dimethyl-5-phenylpyrimidin-4-amine 2-chloro-5-phenyl-4-(piperidin-1-yl)pyrimidine 2-CHLORO-5-(4-CHLOROPHENYL)PYRIMIDINE 2-CHLORO-4-METHOXY-5-PHENYL-PYRIMIDINE 2,4-DICHLORO-6-METHOXY-5-PHENYL-PYRIMIDINE 2,4-DICHLORO-5-(4-ETHOXYPHENYL)PYRIMIDINE 2,4-DICHLORO-5-(4-CHLOROPHENYL)PYRIMIDINE

2-CHLORO-5-PHENYL-PYRIMIDINE

2-Chloro-5-phenyl-pyridimine

PyriMidine,2-chloro-5-phenyl-

2-CHLORO-5-PHENYL-PYRIMIDINE ISO 9001：2015 REACH

22536-62-5

pyrimidine

Heterocycle-Pyrimidine series

pharmacetical