ChemicalBook > CAS DataBase List > 2-CHLORO-5-PHENYL-PYRIMIDINE
2-CHLORO-5-PHENYL-PYRIMIDINE
Application- Product Name
- 2-CHLORO-5-PHENYL-PYRIMIDINE
- CAS No.
- 22536-62-5
- Chemical Name
- 2-CHLORO-5-PHENYL-PYRIMIDINE
- Synonyms
- 2-Chloro-5-phenyl-pyridimine;2-CHLORO-5-PHENYL-PYRIMIDINE;PyriMidine,2-chloro-5-phenyl-;2-CHLORO-5-PHENYL-PYRIMIDINE ISO 9001：2015 REACH
- CBNumber
- CB4428455
- Molecular Formula
- C10H7ClN2
- Formula Weight
- 190.63
- MOL File
- 22536-62-5.mol
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2-CHLORO-5-PHENYL-PYRIMIDINE Property
- Melting point:
- 131-133 °C
- Boiling point:
- 369.9±21.0 °C(Predicted)
- Density
- 1.245±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.71±0.22(Predicted)
- Appearance
- White to off-white Solid
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Safety
- HS Code
- 2933599590
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- B428563
- Product name
- 2-chloro-5-phenylpyrimidine
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR938765
- Product name
- 2-Chloro-5-phenylpyrimidine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $327
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- NUC0001548
- Product name
- 2-CHLORO-5-PHENYL-PYRIMIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.88
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H32-5-MX
- Product name
- 2-Chloro-5-phenylpyrimidine
- Purity
- 95%
- Packaging
- 1g
- Price
- $888
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H32-5-MX
- Product name
- 2-Chloro-5-phenylpyrimidine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $360
- Updated
- 2021/12/16
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2-CHLORO-5-PHENYL-PYRIMIDINE Chemical Properties,Usage,Production
Application
2-Chloro-5-phenylpyrimidine can be used as an organic synthesis intermediate. It can be prepared by reacting 5-bromo-2-chloropyrimidine with Ph3In as a reactant, or by reacting 5-bromo-2-chloropyrimidine with phenylboronic acid via the Suzuki reaction.
Synthesis
32779-36-5
98-80-6
22536-62-5
General procedure: 5-bromo-2-chloropyrimidine (1 eq.), phenylboronic acid (1.1 eq.), Na2CO3 (1.1 eq.) and H2O (5 mL) were added to a round bottom flask, followed by catalyst (2 mol%). The reaction mixture was stirred at 45 °C until the reaction was complete. Upon completion of the reaction, the reaction mixture was diluted with water and the product was extracted with ethyl acetate. The ethyl acetate extract was filtered through a bed of diatomaceous earth and subsequently analyzed by GC. Retention times were verified using standards of 5-bromo-2-chloropyrimidine and 2-chloro-5-phenylpyrimidine to confirm product generation. The ethyl acetate extract was concentrated and purified by silica gel column chromatography using a solvent mixture of hexane and ethyl acetate as eluent to give 2-chloro-5-phenylpyrimidine. The product was characterized by NMR, GC-MS and UPLC analysis.
References
[1] Journal of Heterocyclic Chemistry, 2008, vol. 45, # 4, p. 1077 - 1081
[2] Journal of Molecular Catalysis A: Chemical, 2013, vol. 371, p. 118 - 124
[3] European Journal of Medicinal Chemistry, 2018, vol. 150, p. 30 - 38
[4] Patent: WO2004/22556, 2004, A1. Location in patent: Page 16-17
2-CHLORO-5-PHENYL-PYRIMIDINE Preparation Products And Raw materials
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View Lastest Price from 2-CHLORO-5-PHENYL-PYRIMIDINE manufacturers
Dideu Industries Group Limited
- Product
- 2-CHLORO-5-PHENYL-PYRIMIDINE 22536-62-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-17
Career Henan Chemical Co
- Product
- 2-CHLORO-5-PHENYL-PYRIMIDINE 22536-62-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-08
22536-62-5, 2-CHLORO-5-PHENYL-PYRIMIDINERelated Search:
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2'-Chloro-4'-hydroxyacetophenone
2-CHLORO-5-NITROPYRIMIDIN-4-AMINE
2-Chloro-5-ethylpyrimidine
2-CHLORO-3-FLUOROPHENOL
2-Chloro-3,5-dibromo-4-methylpyridine
2-CHLORO-6-FLUOROPYRIDINE
2-Chloro-8-isopentyl-7-methyl-7,8-dihydropteridin-6(5H)-one
2-CHLORO-5-(4-METHOXYPHENYL)PYRIMIDINE
2-CHLORO-5-PHENYL-PYRIMIDINE
2-chloro-N,N-dimethyl-5-phenylpyrimidin-4-amine
2-chloro-5-phenyl-4-(piperidin-1-yl)pyrimidine
2-CHLORO-5-(4-CHLOROPHENYL)PYRIMIDINE
2-CHLORO-4-METHOXY-5-PHENYL-PYRIMIDINE
2,4-DICHLORO-6-METHOXY-5-PHENYL-PYRIMIDINE
2,4-DICHLORO-5-(4-ETHOXYPHENYL)PYRIMIDINE
2,4-DICHLORO-5-(4-CHLOROPHENYL)PYRIMIDINE