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ChemicalBook > CAS DataBase List > 2-CHLORO-5-PHENYL-PYRIMIDINE

2-CHLORO-5-PHENYL-PYRIMIDINE

Application
Product Name
2-CHLORO-5-PHENYL-PYRIMIDINE
CAS No.
22536-62-5
Chemical Name
2-CHLORO-5-PHENYL-PYRIMIDINE
Synonyms
2-Chloro-5-phenyl-pyridimine;2-CHLORO-5-PHENYL-PYRIMIDINE;PyriMidine,2-chloro-5-phenyl-;2-CHLORO-5-PHENYL-PYRIMIDINE ISO 9001：2015 REACH
CBNumber
CB4428455
Molecular Formula
C10H7ClN2
Formula Weight
190.63
MOL File
22536-62-5.mol
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2-CHLORO-5-PHENYL-PYRIMIDINE Property

Melting point:
131-133 °C
Boiling point:
369.9±21.0 °C(Predicted)
Density 
1.245±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-1.71±0.22(Predicted)
Appearance
White to off-white Solid
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B428563
Product name
2-chloro-5-phenylpyrimidine
Packaging
50mg
Price
$110
Updated
2021/12/16
Apolloscientific
Product number
OR938765
Product name
2-Chloro-5-phenylpyrimidine
Purity
95%
Packaging
250mg
Price
$327
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-MX
Product name
2-Chloro-5-phenylpyrimidine
Purity
95%
Packaging
250mg
Price
$360
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
NUC0001548
Product name
2-CHLORO-5-PHENYL-PYRIMIDINE
Purity
95.00%
Packaging
5MG
Price
$501.88
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-MX
Product name
2-Chloro-5-phenylpyrimidine
Purity
95%
Packaging
1g
Price
$888
Updated
2021/12/16
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2-CHLORO-5-PHENYL-PYRIMIDINE Chemical Properties,Usage,Production

Application

2-Chloro-5-phenylpyrimidine can be used as an organic synthesis intermediate. It can be prepared by reacting 5-bromo-2-chloropyrimidine with Ph3In as a reactant, or by reacting 5-bromo-2-chloropyrimidine with phenylboronic acid via the Suzuki reaction.

Synthesis

32779-36-5

98-80-6

22536-62-5

General procedure: 5-bromo-2-chloropyrimidine (1 eq.), phenylboronic acid (1.1 eq.), Na2CO3 (1.1 eq.) and H2O (5 mL) were added to a round bottom flask, followed by catalyst (2 mol%). The reaction mixture was stirred at 45 °C until the reaction was complete. Upon completion of the reaction, the reaction mixture was diluted with water and the product was extracted with ethyl acetate. The ethyl acetate extract was filtered through a bed of diatomaceous earth and subsequently analyzed by GC. Retention times were verified using standards of 5-bromo-2-chloropyrimidine and 2-chloro-5-phenylpyrimidine to confirm product generation. The ethyl acetate extract was concentrated and purified by silica gel column chromatography using a solvent mixture of hexane and ethyl acetate as eluent to give 2-chloro-5-phenylpyrimidine. The product was characterized by NMR, GC-MS and UPLC analysis.

References

[1] Journal of Heterocyclic Chemistry, 2008, vol. 45, # 4, p. 1077 - 1081
[2] Journal of Molecular Catalysis A: Chemical, 2013, vol. 371, p. 118 - 124
[3] European Journal of Medicinal Chemistry, 2018, vol. 150, p. 30 - 38
[4] Patent: WO2004/22556, 2004, A1. Location in patent: Page 16-17

2-CHLORO-5-PHENYL-PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-5-PHENYL-PYRIMIDINE Suppliers

China 53 India 1 United States 7 Global 61
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 2-CHLORO-5-PHENYL-PYRIMIDINE manufacturers

Dideu Industries Group Limited
Product
2-CHLORO-5-PHENYL-PYRIMIDINE 22536-62-5
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-17
Career Henan Chemical Co
Product
2-CHLORO-5-PHENYL-PYRIMIDINE 22536-62-5
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-08

22536-62-5, 2-CHLORO-5-PHENYL-PYRIMIDINERelated Search:

2-Chloro-4-(Trifluoromethoxy)Bromobenzene 2'-Chloro-4'-hydroxyacetophenone 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE 2-Chloro-5-ethylpyrimidine 2-CHLORO-3-FLUOROPHENOL 2-Chloro-3,5-dibromo-4-methylpyridine 2-CHLORO-6-FLUOROPYRIDINE 2-Chloro-8-isopentyl-7-methyl-7,8-dihydropteridin-6(5H)-one 2-CHLORO-5-(4-METHOXYPHENYL)PYRIMIDINE 2-CHLORO-5-PHENYL-PYRIMIDINE 2-chloro-N,N-dimethyl-5-phenylpyrimidin-4-amine 2-chloro-5-phenyl-4-(piperidin-1-yl)pyrimidine 2-CHLORO-5-(4-CHLOROPHENYL)PYRIMIDINE 2-CHLORO-4-METHOXY-5-PHENYL-PYRIMIDINE 2,4-DICHLORO-6-METHOXY-5-PHENYL-PYRIMIDINE 2,4-DICHLORO-5-(4-ETHOXYPHENYL)PYRIMIDINE 2,4-DICHLORO-5-(4-CHLOROPHENYL)PYRIMIDINE

  • 2-CHLORO-5-PHENYL-PYRIMIDINE
  • 2-Chloro-5-phenyl-pyridimine
  • PyriMidine,2-chloro-5-phenyl-
  • 2-CHLORO-5-PHENYL-PYRIMIDINE ISO 9001：2015 REACH
  • 22536-62-5
  • pyrimidine
  • Heterocycle-Pyrimidine series
  • pharmacetical