3-Acetylthiophene

Product Name: 3-Acetylthiophene
CAS No.: 1468-83-3
Chemical Name: 3-Acetylthiophene
Synonyms: 3-Acetyl;3-Acetylthioph;Acetylthiophene;Acetylthio[hene;3-Acetylthiophen;3-ACETYLTHIOPHENE;Acetylthiophene,97%;Acetylthiophene,95%;3-Acetylthiophene99%;1-thien-3-ylethanone
CBNumber: CB4434894
Molecular Formula: C6H6OS
Formula Weight: 126.18
MOL File: 1468-83-3.mol

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3-Acetylthiophene Property

Melting point:: 57-62 °C (lit.)
Boiling point:: 208-210 °C/748 mmHg (lit.)
Density: 1.176 (estimate)
refractive index: 1.5667 (estimate)
Flash point:: 208-210°C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform, Hexane (Slightly)
form: Adhering Crystals
color: Beige to light brown
Sensitive: Light Sensitive
BRN: 107241
InChIKey: RNIDWJDZNNVFDY-UHFFFAOYSA-N
LogP: 1.240
CAS DataBase Reference: 1468-83-3(CAS DataBase Reference)
NIST Chemistry Reference: Ethanone, 1-(3-thienyl)-(1468-83-3)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 22-24/25-36/37-36-26
RIDADR: UN2811
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 196320
Product name: 3-Acetylthiophene
Purity: 98%
Packaging: 10g
Price: $129
Updated: 2025/07/31

TCI Chemical

Product number: A1006
Product name: 3-Acetylthiophene
Purity: >95.0%(GC)
Packaging: 10g
Price: $115
Updated: 2025/07/31

TCI Chemical

Product number: A1006
Product name: 3-Acetylthiophene
Purity: >95.0%(GC)
Packaging: 25g
Price: $166
Updated: 2023/01/07

TRC

Product number: A188800
Product name: 3-Acetylthiophene
Packaging: 50g
Price: $470
Updated: 2021/12/16

TRC

Product number: A188800
Product name: 3-Acetylthiophene
Packaging: 10g
Price: $120
Updated: 2021/12/16

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3-Acetylthiophene Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

3-Acetylthiophene was used in the preparation of 1-(methylthiophenylidine)-8-naphthylamine(Schiff′s base) and 1-(thiophen-3-yl)ethanone.

Definition

ChEBI: 3-Acetylthiophene is an aromatic ketone.

General Description

3-Acetylthiophene modified glassy carbon electrode has been used in voltammetric determination of uric acid in urine samples.

Synthesis

67237-53-0

1468-83-3

The general procedure for the synthesis of 3-acetylthiophene from 3-ethynylthiophene was as follows: a mixture of 3-ethynylthiophene (232 mg, 2.0 mmol) and S-COPNA (NP) resin (59 mg, 0.2 mmol) in H2O (4 mL) was subjected to refluxing conditions (bath temperature of 120°C) and the reaction was stirred for 8 h at 600 rpm. After completion of the reaction, the catalyst was removed by filtration and washed sequentially with H2O and heptane. A drop of saturated NaHCO3 solution was added to the organic layer, followed by evaporation of the organic solvent under reduced pressure. The residue was purified by column chromatography using heptane-acetone (20:1) as eluent to give finally 3-acetylthiophene (225 mg, 84% yield).

Purification Methods

Recrystallise the thiophene from pet ether (b 30-60o) or EtOH. The 2,4-dinitrophenylhydrazone crystallises from CHCl3, m 265o, and the semicarbazone crystallises from EtOH, m 174-175o. [Campaigne & Le Suer J Am Chem Soc 70 1555 1948, Beilstein 17/9 V 399.]

References

[1] Applied Organometallic Chemistry, 2012, vol. 26, # 12, p. 722 - 726
[2] Tetrahedron Letters, 2017, vol. 58, # 10, p. 955 - 958
[3] Tetrahedron Letters, 2014, vol. 55, # 8, p. 1444 - 1447
[4] ChemSusChem, 2013, vol. 6, # 3, p. 430 - 432

3-Acetylthiophene Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Acetylthiophene Suppliers

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View Lastest Price from 3-Acetylthiophene manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 3-Acetylthiophene 1468-83-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Acetylthiophene 1468-83-3
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-04-22

Hebei Zhanyao Biotechnology Co. Ltd

Product: 3-Acetylthiophene 1468-83-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-10-13

1468-83-3, 3-AcetylthiopheneRelated Search:

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3-Acetylthiophene &gt

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3-Acetylthiophene ISO 9001：2015 REACH

1468-83-3

C6H6OS

Building Blocks

Heterocyclic Building Blocks

Thiophenes

Building Blocks

C4 to C6

Chemical Synthesis

Heterocyclic Building Blocks

Sulphur Derivatives

Thiophene&Benzothiophene

Heterocyclic Compounds

Thiophenes