ChemicalBook > CAS DataBase List > Pleuromulin

Pleuromulin

Product Name
Pleuromulin
CAS No.
125-65-5
Chemical Name
Pleuromulin
Synonyms
bc757;a4014c;Tymosin;NSC 121145;PLEUROMULIN;drosopholinb;Drosophilin B;PLEUROMUTILIN;antibioticbc757;Truncate pleurotin
CBNumber
CB4436641
Molecular Formula
C22H34O5
Formula Weight
378.5
MOL File
125-65-5.mol
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Pleuromulin Property

Melting point:
170-1710C
alpha 
D24 +20° (c = 3 in abs ethanol)
Boiling point:
482.8±45.0 °C(Predicted)
Density 
1.15±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO: >10mg/mL (warmed)
form 
powder
pka
12.91±0.10(Predicted)
color 
white to beige
optical activity
[α]/D +30 to +40° (c=1; CH2Cl2)
InChIKey
YSBXUHAJXRCCET-BKUNHTPHSA-N
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Safety

WGK Germany 
3
RTECS 
MC5408000
Toxicity
LD50 in mice: >60 mg/kg (Kavanagh, 1952)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0285
Product name
Pleuromutilin
Purity
≥95%
Packaging
5mg
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0000586
Product name
Valnemulin impurity E
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000586
Price
$223
Updated
2024/03/01
Cayman Chemical
Product number
19452
Product name
Pleuromutilin
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
19452
Product name
Pleuromutilin
Purity
≥98%
Packaging
10mg
Price
$176
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0285
Product name
Pleuromutilin
Purity
≥95%
Packaging
25mg
Price
$568
Updated
2024/03/01
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Pleuromulin Chemical Properties,Usage,Production

Description

Pleuromutilin is an antibiotic derived from the fungus Clitopilus that inhibits bacterial protein synthesis by binding to bacterial ribosomes in the peptidyl transferase component of the 50S subunit and inhibiting peptide bond formation.

Chemical Properties

Pleuromulin is Crystalline Solid

Uses

Antibiotic substance produced by the basidiomycetes Pleurotus mutilus.

Uses

Pleuromutilin is a diterpene produced by several species of basidomycete, notably the genus Pleurotus, discovered in 1951. Pleuromutilin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Pleuromutilin inhibits protein synthesis by binding to domain V of 23S rRNA and this has led to the development of many semi-synthetic analogues as new generation antibiotics, such as tiamulin and retapamulin.
Pleuromutilins such as tiamulin and valnemulin have been used for some time in veterinary medicine to treat swine infections. More recently a semisynthetic pleuromutilin, retapamulin, has been introduced as a topical treatment for Gram-positive infections in humans. Pleuromutilins inhibit the peptidyl transferase activity of the bacterial 50S ribosomal subunit by binding to the A site.

References

[1]. kilaru s, collins cm, hartley aj, et al. establishing molecular tools for genetic manipulation of the pleuromutilin-producing fungus clitopilus passeckerianus. appl environ microbiol. 2009 nov;75(22):7196-204.
[2]. long ks, hansen lh, jakobsen l, et al. interaction of pleuromutilin derivatives with the ribosomal peptidyl transferase center. antimicrob agents chemother. 2006 apr;50(4):1458-62.

Pleuromulin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Pleuromulin manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
antibioticbc757 125-65-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-30
Hebei Guanlang Biotechnology Co., Ltd.
Product
Pleuromulin 125-65-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-09-03
Wuhan Demeikai Biotechnology Co., Ltd
Product
Pleuromulin 125-65-5
Price
US $10.00/Kg/Bag
Min. Order
10g
Purity
99
Supply Ability
1000KG
Release date
2021-12-21

125-65-5, PleuromulinRelated Search:

Florfenicol Doxycycline Colistin sulfate Enrofloxacin Tylosin Ofloxacin Tilmicosin Ceftiofur sodium Amoxicillin Roxithromycin Tiamulin CHLOROPHOSPHONAZO III Tiamulin fumarate CYCLOUNDECANONE 2-Iso-butylcyclopentanone VINYLCYCLOOCTANE Pleuromulin

  • PLEUROMULIN
  • PLEUROMUTILIN
  • a4014c
  • antibioticbc757
  • bc757
  • drosopholinb
  • glycolicacid,8-esterwithoctahydro-5,8-dihydroxy-4,6,9,10-tetramethyl-6-viny
  • l-3a,9-propano-3ah-cyclopentacycloocten-1(4h)-one
  • 2-Hydroxyacetic Acid (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl Ester
  • 5-Hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl hydroxyacetate
  • Drosophilin B
  • Acetic acid, 2-hydroxy-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
  • Glycolic acid, 8-ester with octahydro-5,8-dihydroxy-4,6,9,10-tetramethyl-6-vinyl-3a,9-propano-3aH-cyclopentacycloocten-1(4H)-one
  • Glycolic acid (10R)-6-ethenyldecahydro-5α-hydroxy-4β,6β,9β,10-tetramethyl-1-oxo-3aα,9α-propano-3aH-cyclopentacycloocten-8β-yl
  • Glycolic acid (10R)-6-ethenyldecahydro-5α-hydroxy-4β,6β,9β,10-tetramethyl-1-oxo-3aα,9α-propano-3aH-cyclopentacycloocten-8β-yl ester
  • PleuroMutilin antibacterial drugs
  • PleuroMulin 95% 97%
  • Drosophilin B, A 40104C
  • Mutilin 14-glycolate
  • NSC 121145
  • Tiamulin EP Impurity G
  • Pleuromulin Manufacturer / In stock factory
  • Valnemulin impurity E CRS
  • Truncate pleurotin
  • Valnemulin hydrochloride EP Impurity E
  • (3aS，4R，5S，6S，8R，9R，9aR，12R)-5-Hydroxy-4，6，9，12-tetramethyl-1-oxo-6-vinyldecahydro-3a，9-propanocyclopenta[8]annulen-8-yl 2-hydroxyacetate
  • Acetic acid, hydroxy-,(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-ylester
  • (2R,3S,4S,6R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxotricyclo[5.4.3.01,?]tetradecan-6-yl 2-hydroxyacetate
  • PleuromutilinQ: What is Pleuromutilin Q: What is the CAS Number of Pleuromutilin Q: What is the storage condition of Pleuromutilin Q: What are the applications of Pleuromutilin
  • Tymosin
  • Pleuromutilin (6CI, 7CI)
  • Tiamulin Hydrogen Fumarate Impurity G
  • Valnemulin Hydrochloride Impurity E
  • Tiamulin Hydrogen Fumarate EP Impurity G
  • Tiamulin Impurity 7 (Tiamulin EP Impurity G)
  • Codeine Phosphate Impurity 6 (Codeine Phosphate EP Impurity F)
  • Truncated pleurotin
  • Tiamulin EP Impurity G (Valnemulin EP Impurity E)
  • (3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-Hydroxyacetate
  • Truncated lateral ear extract
  • 125-65-5
  • Intermediates & Fine Chemicals
  • Pharmaceuticals