Tilmicosin

Brief introduction Chemical Properties Uses

Product Name: Tilmicosin
CAS No.: 108050-54-0
Chemical Name: Tilmicosin
Synonyms: Timicosin;Tilmicosine;pulmotil;Dianthi Herba;EL 870;Stmicco;Micotil;LY 177370;Timicoxin;TILMICOSIN
CBNumber: CB6463168
Molecular Formula: C46H80N2O13
Formula Weight: 869.15
MOL File: 108050-54-0.mol

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Tilmicosin Property

Melting point:: >97°C (dec.)
alpha: D23 +12.75° (c = 0.010004 in CHCl3, 5 cm)
Boiling point:: 926.6±65.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Acetone (Slightly), DMSO (Slightly), Methanol (Sparingly)
pka: pKa (66% DMF): 7.4, 8.5(at 25℃)
color: White to Off-White
InChIKey: JTSDBFGMPLKDCD-XVFHVFLVSA-N
EPA Substance Registry System: Tilmicosin (108050-54-0)

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Safety

WGK Germany: 3
HS Code: 29419090
Hazardous Substances Data: 108050-54-0(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 33864
Product name: Tilmicosin
Purity: VETRANAL?, analytical standard, mix of isomers
Packaging: 100mg
Price: $119
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1667370
Product name: Tilmicosin
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 250mg
Price: $436
Updated: 2024/03/01

Usbiological

Product number: 257406
Product name: Tilmicosin
Packaging: 500mg
Price: $531
Updated: 2021/12/16

TRC

Product number: T440500
Product name: Tilmicosin,85%
Packaging: 50mg
Price: $70
Updated: 2021/12/16

AK Scientific

Product number: A574
Product name: Tilmicosin,mixtureofisomers
Packaging: 1g
Price: $312
Updated: 2021/12/16

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Tilmicosin Chemical Properties,Usage,Production

Brief introduction

Tilmicosin is a relatively novel semi-synthetic macrolide antibiotics derived from tylosin for being applied to livestock and poultry. The chemical name is 4A-O-de (2, 6-dideoxy-methyl-3-C--L-ribose-pyran-hexyl)-20-deoxy-20-(3,5-dimethyl-1-piperidinyl)-[20 (cis: trans)] tylosin. Molecule formula is C46H80N2O13 and the molecular weight of 869.15.
Tilmicosin has a similar antibacterial spectrum as tylosin but has enhanced effect on the anti-Pasteurella multocida and hemolytic pasteurella. It was successfully developed in 1980s and initially used with a code of EL-870. Common trade names include Pulmotil © Micotil ©, preparations include tilmicosin soluble powder, premix (20%) preparation, and injection. In 1990 it was approved in most European countries; it was approved in the US in 1992, and included in USP. China also has some domestic enterprises approved for production of tilmicosin.
Because of its special antibacterial activity and pharmacokinetic characteristics, the drug has been approved for clinical prevention and treatment of infectious diseases for cattle, goats, sheep, cows, pigs, and chickens. It is especially applied to the treatment of respiratory diseases of livestock, such as cattle Actinobacillus pleuropneumonia, Pasteurella disease, chicken mycoplasmosis and mastitis of lactating animals.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Chemical Properties

It is white or white powder with humidity: ≤5.0%.

Uses

It can be used as anti-bacterial.
It is mainly used for the treatment of infection caused by pleuropneumonia, Actinobacillus, Pasteurella and mycoplasma.

Chemical Properties

White Solid

Uses

Tilmicosin is a semi-synthetic antibiotic derived from desmycosin (tylosin B), a minor co-metabolite of tylosin. Tilmicosin is produced by reductive amination of desmycosin. Desmycosin itself is prepared by the partial hydrolysis of tylosin with the loss of the mycarosyl sugar. The piperidinyl group at C20 of tilmicosin provides a wider spectrum of antibiotic action, in particular good protection against Pasteurella in livestock.

Uses

A Macrolide antibiotic.

Uses

Macrolide antibiotic structurally related to tylosin. Antibacterial

Veterinary Drugs and Treatments

Tilmicosin is indicated for the treatment of bovine or ovine respiratory diseases (BRD) caused by Mannheimia (Pasturella) haemolytica.

Tilmicosin Preparation Products And Raw materials

Raw materials

Preparation Products

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Tilmicosin Suppliers

Canada 1 China 365 Europe 2 Germany 3 India 6 Japan 3 Singapore 1 South Korea 1 Switzerland 1 United Kingdom 11 United States 28 Global 422

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

BeiJing Hwrk Chemicals Limted

Tel: 0757-86329057 18501085097
Fax: 010-89508210
Email: sales3.gd@hwrkchemical.com
Country: China
ProdList: 7583
Advantage: 55

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10194
Advantage: 62

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9816
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 0712-0712-2580635 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8849
Advantage: 52

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7815
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9823
Advantage: 79

Wuhan Sinocon New chemical Materials Co.,ltd.

Tel: 027-83229541 13971313286
Fax: 027-83096702
Email: whsinocon@aliyun.com
Country: China
ProdList: 127
Advantage: 62

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View Lastest Price from Tilmicosin manufacturers

Henan Suikang Pharmaceutical Co.,Ltd.

Product: Tilmicosin 108050-54-0
Price: US $0.00/kg
Min. Order: 25kg
Purity: ＞85%
Supply Ability: 10tons
Release date: 2024-04-24

Hebei ZB Gamay Biological Technology Co.,Ltd

Product: Tilmicosin 108050-54-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 85%
Supply Ability: 1000kg
Release date: 2022-11-22

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Tilmicosin 108050-54-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000KG
Release date: 2024-03-27

108050-54-0, TilmicosinRelated Search:

TILMICOSIN PHOSPHATE Dacthal Dimethyl ether Dimethyl carbonate ETHANE N,N-Dimethylformamide Dimethyl disulfide Dimethyl fumarate Dimethyl sulfoxide Dimethyl sulfate Dimethyl phthalate Tilorone dihydrochloride Tilmicosin phosphate 8,10-DODECADIEN-1-OL Tilmicosin (FDA) Tylosin ISO-PROPYL-UNDECYLENATE (R)-3-METHYL-4-TETRAHYDROPYRANYLOXYBUTYLAMINE

4'-O-De(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-20-deoxo-20-(3,5-dimethyl-1-piperidinyl)tyrosine [antibiotic]

Tilmicosin,20-Deoxo-20-(3,5-dimethyl-1-piperidinyl)desmycosin

Tilmicosin (250 mg)

Herba Dianthi Superbi

(11Z,13Z)-6-{[4-(diMethylaMino)-3,5-dihydroxy-6-Methyloxan-2-yl]oxy}-7-[2-(3,5-diMethylpiperidin-1-yl)ethyl]-16-ethyl-4-hydroxy-15-{[(5-hydroxy-3,4-diMethoxy-6-Methyloxan-2-yl)oxy]Methyl}-5,9,13-triMethyl-1-oxacyclohexadeca-11,13-diene-2,10-dione

20-Deoxy-20-(3,5-diMethylpiperidin-1-yl)-desMycosin, EL-870

Tylosin, 4A-O-de(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-20-deoxo-20-[(3R,5S)-3,5-dimethyl-1-piperidinyl]-

20%Tilmicosin

Tilmicosin Base

Stmicco

Tilmicosin Solution, 1000ppm

Tilmicosin CAS 108050-54-0

Tilmicosin,85%

20-DEOXO-20-(3,5-DIMETHYL-1-PIPERIDINYL)DESMYCOSIN

Tylosin, 4A-O-de(2,6-dideoxy-3-C-methyl-.alpha.-L-ribo-hexopyranosyl)-20-deoxo-20-(3R,5S)-3,5-dimethyl-1-piperidinyl-

pulmotil

TILMICOSIN

Tilmicosin, Vetranal

Tilmicosine

4A-O-De(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-20-deoxo-20-[(3R,5S)-3,5-dimethyl-1-piperidinyl]tylosin

Antibiotic EL 870

EL 870

LY 177370

Micotil

Micotil 300

4A-O-De(2,6-dideoxy-3-C-methyl-a-L-ribo-hexopyranosyl)-20-deoxo-20-[(3R,5S)-3,5-dimethyl-1-piperidinyl]tylosin

Dianthi Herba

Qumai extract

6-[[4-(dimethylamino)-3,5-dihydroxy-6-methyl-2-oxanyl]oxy]-7-[2-(3,5-dimethyl-1-piperidinyl)ethyl]-16-ethyl-4-hydroxy-15-[(5-hydroxy-3,4-dimethoxy-6-methyl-2-oxanyl)oxymethyl]-5,9,13-trimethyl-1-oxacy

Tilmicosin Standard(mixture of isomers)

(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-(((2R,3R,4S,5S,6R)-4-(Dimethylamino)-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-7-(2-((3R,5S)-3,5-dimethylpiperidin-1-yl)ethyl)-16-ethyl-4-hydroxy-15-((((2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)-5,9,13-trimethyloxacyclohexadeca-11,13-diene-2,10-dione

Tilmicosin USP/EP/BP

Timicosin

Dianthi extract

TilmicosinQ: What is Tilmicosin Q: What is the CAS Number of Tilmicosin Q: What is the storage condition of Tilmicosin Q: What are the applications of Tilmicosin

Tilmicosin (API)

Tilmicosin (1667370)

Timicoxin

108050-54-0

08050-54-0

C46H80N2O13

API

Pharmaceutical intermediate

Intermediates & Fine Chemicals

Pharmaceuticals

Chiral Reagents

Active Pharmaceutical Ingredients