Brief introduction Chemical Properties Uses
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Tilmicosin

Brief introduction Chemical Properties Uses
Product Name
Tilmicosin
CAS No.
108050-54-0
Chemical Name
Tilmicosin
Synonyms
Timicosin;Tilmicosine;pulmotil;Dianthi Herba;EL 870;Stmicco;Micotil;LY 177370;Timicoxin;TILMICOSIN
CBNumber
CB6463168
Molecular Formula
C46H80N2O13
Formula Weight
869.15
MOL File
108050-54-0.mol
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Tilmicosin Property

Melting point:
>97°C (dec.)
alpha 
D23 +12.75° (c = 0.010004 in CHCl3, 5 cm)
Boiling point:
926.6±65.0 °C(Predicted)
Density 
1.18±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Acetone (Slightly), DMSO (Slightly), Methanol (Sparingly)
pka
pKa (66% DMF): 7.4, 8.5(at 25℃)
form 
Solid
color 
White to Off-White
InChIKey
JTSDBFGMPLKDCD-XVFHVFLVSA-N
EPA Substance Registry System
Tilmicosin (108050-54-0)
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Safety

WGK Germany 
3
HS Code 
29419090
Hazardous Substances Data
108050-54-0(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
33864
Product name
Tilmicosin
Purity
VETRANAL?, analytical standard, mix of isomers
Packaging
100mg
Price
$119
Updated
2024/03/01
Sigma-Aldrich
Product number
1667370
Product name
Tilmicosin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
250mg
Price
$436
Updated
2024/03/01
Usbiological
Product number
257406
Product name
Tilmicosin
Packaging
500mg
Price
$531
Updated
2021/12/16
TRC
Product number
T440500
Product name
Tilmicosin,85%
Packaging
50mg
Price
$70
Updated
2021/12/16
AK Scientific
Product number
A574
Product name
Tilmicosin,mixtureofisomers
Packaging
1g
Price
$312
Updated
2021/12/16
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Tilmicosin Chemical Properties,Usage,Production

Brief introduction

Tilmicosin is a relatively novel semi-synthetic macrolide antibiotics derived from tylosin for being applied to livestock and poultry. The chemical name is 4A-O-de (2, 6-dideoxy-methyl-3-C--L-ribose-pyran-hexyl)-20-deoxy-20-(3,5-dimethyl-1-piperidinyl)-[20 (cis: trans)] tylosin. Molecule formula is C46H80N2O13 and the molecular weight of 869.15.
Tilmicosin has a similar antibacterial spectrum as tylosin but has enhanced effect on the anti-Pasteurella multocida and hemolytic pasteurella. It was successfully developed in 1980s and initially used with a code of EL-870. Common trade names include Pulmotil © Micotil ©, preparations include tilmicosin soluble powder, premix (20%) preparation, and injection. In 1990 it was approved in most European countries; it was approved in the US in 1992, and included in USP. China also has some domestic enterprises approved for production of tilmicosin.
Because of its special antibacterial activity and pharmacokinetic characteristics, the drug has been approved for clinical prevention and treatment of infectious diseases for cattle, goats, sheep, cows, pigs, and chickens. It is especially applied to the treatment of respiratory diseases of livestock, such as cattle Actinobacillus pleuropneumonia, Pasteurella disease, chicken mycoplasmosis and mastitis of lactating animals.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Chemical Properties

It is white or white powder with humidity: ≤5.0%.

Uses

It can be used as anti-bacterial.
It is mainly used for the treatment of infection caused by pleuropneumonia, Actinobacillus, Pasteurella and mycoplasma.

Chemical Properties

White Solid

Uses

Tilmicosin is a semi-synthetic antibiotic derived from desmycosin (tylosin B), a minor co-metabolite of tylosin. Tilmicosin is produced by reductive amination of desmycosin. Desmycosin itself is prepared by the partial hydrolysis of tylosin with the loss of the mycarosyl sugar. The piperidinyl group at C20 of tilmicosin provides a wider spectrum of antibiotic action, in particular good protection against Pasteurella in livestock.

Uses

A Macrolide antibiotic.

Uses

Macrolide antibiotic structurally related to tylosin. Antibacterial

Veterinary Drugs and Treatments

Tilmicosin is indicated for the treatment of bovine or ovine respiratory diseases (BRD) caused by Mannheimia (Pasturella) haemolytica.

Tilmicosin Preparation Products And Raw materials

Raw materials

Preparation Products

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Tilmicosin Suppliers

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View Lastest Price from Tilmicosin manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Tilmicosin 108050-54-0
Price
US $1000.00-400.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-12
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Tilmicosin 108050-54-0
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
85%
Supply Ability
500KG
Release date
2021-09-18
Henan Suikang Pharmaceutical Co.,Ltd.
Product
Tilmicosin 108050-54-0
Price
US $0.00/kg
Min. Order
25kg
Purity
＞85%
Supply Ability
10tons
Release date
2024-04-24

108050-54-0, TilmicosinRelated Search:

TILMICOSIN PHOSPHATE Dacthal Dimethyl ether Dimethyl carbonate ETHANE N,N-Dimethylformamide Dimethyl disulfide Dimethyl fumarate Dimethyl sulfoxide Dimethyl sulfate Dimethyl phthalate Tilorone dihydrochloride Tilmicosin phosphate 8,10-DODECADIEN-1-OL Tilmicosin (FDA) Tylosin ISO-PROPYL-UNDECYLENATE (R)-3-METHYL-4-TETRAHYDROPYRANYLOXYBUTYLAMINE

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