ChemicalBook > CAS DataBase List > N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE

N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE

Description

Product Name: N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE
CAS No.: 132172-61-3
Chemical Name: N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE
Synonyms: DOTAP;DOTMA;dotap chloride;1,2-dioleoyl-3-trimethylammonium-propane (chloride salt);NSC8484;NSC 8484;NSC-8484;DOTAP-Cl;Lipofectin;18:1 TAP (DOTAP)
CBNumber: CB4441795
Molecular Formula: C42H80ClNO4
Formula Weight: 698.56
MOL File: 132172-61-3.mol

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N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE Property

Melting point:: 35-38°C
storage temp.: -20°C
solubility: Chloroform (Slightly)
form: lyophilized powder
color: White to Pale Yellow
Stability:: Store in Freezer, Hygroscopic
InChIKey: KSXTUUUQYQYKCR-LQDDAWAPSA-M
SMILES: C(C[N+](C)(C)C)(COC(=O)CCCCCCC/C=C\CCCCCCCC)OC(=O)CCCCCCC/C=C\CCCCCCCC.[Cl-]

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D6182
Product name: DOTAP chloride
Purity: ≥98% (TLC), powder
Packaging: 50mg
Price: $476
Updated: 2025/07/31

Sigma-Aldrich

Product number: D6182
Product name: DOTAP chloride
Purity: ≥98% (TLC), powder
Packaging: 250mg
Price: $1890
Updated: 2025/07/31

TCI Chemical

Product number: D5916
Product name: N-(2,3-Dioleoyloxy)propyl-N,N,N-trimethylammonium Chloride
Packaging: 250MG
Price: $252
Updated: 2025/07/31

TCI Chemical

Product number: D5916
Product name: N-(2,3-Dioleoyloxy)propyl-N,N,N-trimethylammonium Chloride
Packaging: 1G
Price: $629
Updated: 2025/07/31

Cayman Chemical

Product number: 15110
Product name: 1,2-Dioleoyl-3-trimethylammoniumpropane (chloride)
Purity: ≥95%
Packaging: 50mg
Price: $73
Updated: 2024/03/01

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N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE Chemical Properties,Usage,Production

Description

DOTAP chloride (1,2-Dioleoyl-3-trimethylammonium-propane chloride) is a potent cationic lipid widely used as a liposomal transfection reagent. DOTAP is also a strong activator of the innate immune system in animal cells and could serve as a potential candidate for the study of elicitors of plant immunity.

Description

DOTAP, 1,2-Dioleoyl-3-trimethylammonium propane is a di-chain, or gemini, cationic surfactant. DOTAP has been used for in vitro and in vivo nucleic acid and protein delivery.

Chemical Properties

White Foam

Uses

Small unilamellar liposomes containing DOTMA interact spontaneously with DNA to form lipid-DNA complexes with 100% entrapment of DNA. Facilitates fusion of the complex with the plasma membrane of tissue culture cells, resulting in both uptake and

Uses

1,2-dioleoyloxy-3-(trimethylammonium)propane (DOTAP) chloride has been used for the preparation of cationic liposome and liposome-DNA complex. It has also been used to assess tumor necrosis factor α (TNF- α) production.

Biochem/physiol Actions

18:1 TAP (DOTAP) is a cationic lipid structure, used for in vitro and in vivo nucleic acid and protein delivery. The lipid composition and cell type affects the transfection potential of DOTAP(1,2-dioleoyl-3-trimethylammonium-propane). 18:1 TAP (DOTAP) mediates gene knockdown technique in hematopoietic stem cells (HSCs).

N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE Suppliers

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View Lastest Price from N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: DOTAP chloride 132172-61-3
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-09-08

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: DOTAP-Cl 132172-61-3
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle , 10g/bottle, 100g/bottle
Release date: 2024-07-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE 132172-61-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

132172-61-3, N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDERelated Search:

Cholesterol PG?(egg?PC) Cholesteryl sodium sulfate Egg phospholipids Sodium hyaluronate DODMA DOTAP Ammonium chloride DOTAP MESYLATE, 98 N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE,N-[1-(2,3-DIOLEOYLOXY) PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE,DOTAP CHLORIDE SALT,DOTAP DOTAP DOTAP methyl sulfate,DOTAP,DOTAP METHOSULFATE DOTAP MESYLATE DOTAP METHYL SULPHATE SALT DOTAP DOTAP(OH) MESYLATE DOTAP acetate DOTAP(OH)2 MESYLATE

1,2-DIOLEOYL-3-TRIMETHYLAMMONIUM-PROPANE, CHLORIDE

DOTMA

DOTAP CHLORIDE SALT

DOTAP

dotap chloride

N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE

N-[1-(2,3-DIOLEOYLOXY)PROPYL]-N,N,N-TRIMETHYL-AMMONIUM CHLORIDE SALT

N-[1-(2,3-DIOLEOYLOXY) PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE

TRIMETHYL[2,3-(DIOLEYLOXY)PROPYL]AMMONIUM CHLORIDE

2,3-Bis(oleoyloxy)-N,N,N-trimethyl-1-propanaminium

3-(Trimethylaminio)propane-1,2-diol 1,2-bis[(Z)-9-octadecenoate]

Lipofectin

N-[2,3-Bis(oleoyloxy)propyl]-N,N-dimethylmethanaminium

N-[2,3-Di(oleoyloxy)propyl]-N,N,N-trimethylaminium

N,N,N-TriMethyl-2,3-bis[[(9Z)-1-oxo-9-octadecenyl]oxy]-1-propanaMiniuM

DOTAP;DOTAP, CHLORIDE

1,2-dioleoyl-3-trimethylammonium-propane (chloride salt)

18:1 TAP (DOTAP)

2,3-di(octadec-9-enoyloxy)propyl-trimethylazanium

(2，3-Dioleyl-propyl) -trimethylamine

N,N,N-Trimethyl-2,3-bis(oleoyloxy)propan-1-aminium chloride

1-Propanaminium, N,N,N-trimethyl-2,3-bis[[(9Z)-1-oxo-9-octadecenyl]oxy]-, chloride (1:1)

NSC 8484

NSC8484

NSC-8484

DOTAP-Cl

N-(2,3-Dioleoyloxy)propyl-N,N,N-trimethylammonium Chloride

DOTAP (chloride salt) (2,3-dioleoyl-propyl) - trimethylamine (chloride salt)

DOTAP chloride, 10 mM in DMSO

(2,3-dioxopropyl) trimethylammonium chloride

N-[2,3-Di(Oleoyloxy)propyl]-N,N,N-trimethylaminium chloride

132172-61-3

C42H80ClNO4

C40H80ClNO2

C42H80NO4Cl

Ammonium Chlorides (Quaternary)

Quaternary Ammonium Compounds

BioChemical

Cloning and Expression

Molecular Biology

Transfection & Transformation

Fatty Acid Derivatives & Lipids

Glycerols

Mixed Fatty Acids