2-CHLORO-4-ETHOXYPYRIDINE

Uses

Product Name: 2-CHLORO-4-ETHOXYPYRIDINE
CAS No.: 52311-50-9
Chemical Name: 2-CHLORO-4-ETHOXYPYRIDINE
Synonyms: 2-CHLORO-4-ETHOXYPYRIDINE;Pyridine, 2-chloro-4-ethoxy-;Benzenesulfonamide,4-amino-N-(4-phenylethyl)-
CBNumber: CB4442222
Molecular Formula: C7H8ClNO
Formula Weight: 157.6
MOL File: 52311-50-9.mol

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2-CHLORO-4-ETHOXYPYRIDINE Property

Melting point:: 55-57 °C
Boiling point:: 230.9±20.0 °C(Predicted)
Density: 1.166±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 2.25±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C433313
Product name: 2-Chloro-4-ethoxypyridine
Packaging: 500mg
Price: $220
Updated: 2021/12/16

Apolloscientific

Product number: OR959740
Product name: 2-chloro-4-ethoxypyridine
Purity: 95%
Packaging: 1g
Price: $335
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0118477
Product name: 2-CHLORO-4-ETHOXYPYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $495.69
Updated: 2021/12/16

AK Scientific

Product number: R739
Product name: 2-Chloro-4-ethoxypyridine
Packaging: 5g
Price: $512
Updated: 2021/12/16

AK Scientific

Product number: R739
Product name: 2-Chloro-4-ethoxypyridine
Packaging: 25g
Price: $1820
Updated: 2021/12/16

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2-CHLORO-4-ETHOXYPYRIDINE Chemical Properties,Usage,Production

Uses

2-Chloro-4-ethoxypyridine is a useful research chemical.

Synthesis

23056-36-2

141-52-6

52311-50-9

GENERAL STEPS: A solution of 2-chloro-4-nitropyridine (170 g, 1070 mmol) in THF (2 L) was slowly added to sodium ethoxide (109.45 g, 1610 mmol) at 0 °C. The reaction mixture was stirred at 25°C for 12 hours. The completion of the reaction was monitored by LCMS and TLC (unfolding agent: petroleum ether/ethyl acetate = 5:1, Rf = 0.6). After completion of the reaction, the mixture was filtered and the filtrate was concentrated under reduced pressure to remove most of the solvent. The residue was extracted with ethyl acetate (800 mL x 3), the organic layer was washed with saturated sodium chloride solution (1 L), dried over anhydrous sodium sulfate, and concentrated to give 2-chloro-4-ethoxypyridine (157 g, 1.0 mol, 92% yield) as a solid.1H NMR (400 MHz, CD3OD) δ 8.15 (d, J=6.0 Hz, 1H), 6.99 (d , J=2.0Hz, 1H), 6.91-6.89 (m, 1H), 4.16-4.14 (m, 2H), 1.41-1.38 (m, 3H). es-lcms m/z 158 ([M+H]+).

References

[1] Patent: WO2016/37578, 2016, A1. Location in patent: Page/Page column 71; 72
[2] Patent: WO2016/38519, 2016, A1. Location in patent: Page/Page column 34; 35
[3] Patent: WO2016/38552, 2016, A1. Location in patent: Page/Page column 49
[4] Patent: WO2014/141187, 2014, A1. Location in patent: Page/Page column 112; 52; 53
[5] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 7, p. 623 - 628

2-CHLORO-4-ETHOXYPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-4-ETHOXYPYRIDINE Suppliers

China 58 Germany 1 India 1 United Kingdom 1 United States 6 Global 67

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52311-50-9, 2-CHLORO-4-ETHOXYPYRIDINERelated Search:

5-Chloro-2,3-difluoropyridine 3,5,6-Trichloro-2-pyridinol 4-ETHOXYPYRIDINE 2-CHLORO-4-ETHOXYPYRIDINE 6-Chloro-4-ethoxypyridine-3-carboxylic acid ethyl ester 2-CHLORO-4-ETHOXYNICOTINONITRILE SPECS AC-907/25004653 5,9-DICHLORO-3-(2-CHLOROETHYL)-4-METHYL-2H-PYRANO[3,2-C]QUINOLIN-2-ONE 2-CHLORO-4-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDINE 6-CHLORO-4-ETHOXYNICOTINIC ACID CYCLOPENTYL 6-CHLORO-4-(CYCLOPENTYLOXY)-2-METHYLNICOTINATE 5-CHLORO-3-(2-CHLOROETHYL)-7-METHYL-2H-PYRANO[3,2-C]PYRIDIN-2-ONE 2,6-Dichloro-4-ethoxypyridine 2-CHLORO-4-ETHOXYQUINOLINE

2-CHLORO-4-ETHOXYPYRIDINE

Pyridine, 2-chloro-4-ethoxy-

Benzenesulfonamide,4-amino-N-(4-phenylethyl)-

52311-50-9