ChemicalBook > CAS DataBase List > 2-CHLORO-4-ETHOXYPYRIDINE
2-CHLORO-4-ETHOXYPYRIDINE
Uses- Product Name
- 2-CHLORO-4-ETHOXYPYRIDINE
- CAS No.
- 52311-50-9
- Chemical Name
- 2-CHLORO-4-ETHOXYPYRIDINE
- Synonyms
- 2-CHLORO-4-ETHOXYPYRIDINE;Pyridine, 2-chloro-4-ethoxy-;Benzenesulfonamide,4-amino-N-(4-phenylethyl)-
- CBNumber
- CB4442222
- Molecular Formula
- C7H8ClNO
- Formula Weight
- 157.6
- MOL File
- 52311-50-9.mol
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2-CHLORO-4-ETHOXYPYRIDINE Property
- Melting point:
- 55-57 °C
- Boiling point:
- 230.9±20.0 °C(Predicted)
- Density
- 1.166±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 2.25±0.10(Predicted)
- Appearance
- White to off-white Solid
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Safety
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- C433313
- Product name
- 2-Chloro-4-ethoxypyridine
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR959740
- Product name
- 2-chloro-4-ethoxypyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $335
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0118477
- Product name
- 2-CHLORO-4-ETHOXYPYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.69
- Updated
- 2021/12/16
AK Scientific
- Product number
- R739
- Product name
- 2-Chloro-4-ethoxypyridine
- Packaging
- 5g
- Price
- $512
- Updated
- 2021/12/16
AK Scientific
- Product number
- R739
- Product name
- 2-Chloro-4-ethoxypyridine
- Packaging
- 25g
- Price
- $1820
- Updated
- 2021/12/16
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2-CHLORO-4-ETHOXYPYRIDINE Chemical Properties,Usage,Production
Uses
2-Chloro-4-ethoxypyridine is a useful research chemical.
Synthesis
23056-36-2
141-52-6
52311-50-9
GENERAL STEPS: A solution of 2-chloro-4-nitropyridine (170 g, 1070 mmol) in THF (2 L) was slowly added to sodium ethoxide (109.45 g, 1610 mmol) at 0 °C. The reaction mixture was stirred at 25°C for 12 hours. The completion of the reaction was monitored by LCMS and TLC (unfolding agent: petroleum ether/ethyl acetate = 5:1, Rf = 0.6). After completion of the reaction, the mixture was filtered and the filtrate was concentrated under reduced pressure to remove most of the solvent. The residue was extracted with ethyl acetate (800 mL x 3), the organic layer was washed with saturated sodium chloride solution (1 L), dried over anhydrous sodium sulfate, and concentrated to give 2-chloro-4-ethoxypyridine (157 g, 1.0 mol, 92% yield) as a solid.1H NMR (400 MHz, CD3OD) δ 8.15 (d, J=6.0 Hz, 1H), 6.99 (d , J=2.0Hz, 1H), 6.91-6.89 (m, 1H), 4.16-4.14 (m, 2H), 1.41-1.38 (m, 3H). es-lcms m/z 158 ([M+H]+).
References
[1] Patent: WO2016/37578, 2016, A1. Location in patent: Page/Page column 71; 72
[2] Patent: WO2016/38519, 2016, A1. Location in patent: Page/Page column 34; 35
[3] Patent: WO2016/38552, 2016, A1. Location in patent: Page/Page column 49
[4] Patent: WO2014/141187, 2014, A1. Location in patent: Page/Page column 112; 52; 53
[5] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 7, p. 623 - 628
2-CHLORO-4-ETHOXYPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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52311-50-9, 2-CHLORO-4-ETHOXYPYRIDINERelated Search:
5-Chloro-2,3-difluoropyridine
3,5,6-Trichloro-2-pyridinol
4-ETHOXYPYRIDINE
2-CHLORO-4-ETHOXYPYRIDINE
6-Chloro-4-ethoxypyridine-3-carboxylic acid ethyl ester
2-CHLORO-4-ETHOXYNICOTINONITRILE
SPECS AC-907/25004653
5,9-DICHLORO-3-(2-CHLOROETHYL)-4-METHYL-2H-PYRANO[3,2-C]QUINOLIN-2-ONE
2-CHLORO-4-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDINE
6-CHLORO-4-ETHOXYNICOTINIC ACID
CYCLOPENTYL 6-CHLORO-4-(CYCLOPENTYLOXY)-2-METHYLNICOTINATE
5-CHLORO-3-(2-CHLOROETHYL)-7-METHYL-2H-PYRANO[3,2-C]PYRIDIN-2-ONE
2,6-Dichloro-4-ethoxypyridine
2-CHLORO-4-ETHOXYQUINOLINE