4-Bromo-1H-indazole
- Product Name
- 4-Bromo-1H-indazole
- CAS No.
- 186407-74-9
- Chemical Name
- 4-Bromo-1H-indazole
- Synonyms
- 4-BROMOINDAZOLE;broMo-1H-indazole;4-Bromoindazole >4-BROMO (1H)INDAZOLE;1H-Indazole, 4-bromo-;4-BroMo-1H-indazole, 97+%;4-bromo-1H-indazole￡4-Bromoindazole;186407-74-9
- CBNumber
- CB4442606
- Molecular Formula
- C7H5BrN2
- Formula Weight
- 197.03
- MOL File
- 186407-74-9.mol
4-Bromo-1H-indazole Property
- Melting point:
- 165-167°
- Boiling point:
- 333.8±15.0 °C(Predicted)
- Density
- 1.770±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- soluble in Ethanol
- form
- Solid
- pka
- 12.78±0.40(Predicted)
- color
- Off-white
- InChI
- InChI=1S/C7H5BrN2/c8-6-2-1-3-7-5(6)4-9-10-7/h1-4H,(H,9,10)
- InChIKey
- KJIODOACRIRBPB-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(Br)=CC=C2)C=N1
- CAS DataBase Reference
- 186407-74-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 25-36/37/38
- Safety Statements
- 26-45
- RIDADR
- 2811
- WGK Germany
- 3
- HazardClass
- 6.1
- HazardClass
- IRRITANT
- PackingGroup
- Ⅲ
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 776610
- Product name
- 4-Bromo-1H-indazole
- Purity
- 95%
- Packaging
- 5g
- Price
- $113
- Updated
- 2024/03/01
- Product number
- 776610
- Product name
- 4-Bromo-1H-indazole
- Purity
- 95%
- Packaging
- 1g
- Price
- $29
- Updated
- 2023/06/20
- Product number
- B4631
- Product name
- 4-Bromoindazole
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $55
- Updated
- 2024/03/01
- Product number
- B4631
- Product name
- 4-Bromoindazole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $217
- Updated
- 2024/03/01
- Product number
- H64527
- Product name
- 4-Bromo-1H-indazole, 97+%
- Packaging
- 5g
- Price
- $71.65
- Updated
- 2024/03/01
4-Bromo-1H-indazole Chemical Properties,Usage,Production
Description
4-Bromo-1H-indazole is a derivative indazole which has a heterocyclic structure made up of benzene and pyrazole rings. Indazoles are an important class of heterocyclic compounds with a wide range of application as biologic and pharmaceutic agents. Indazole derivatives have a wide range of biological activities. For instance, indazole derivatives show vasorelaxant and anti-aggregator activities by stimulating NO release and increasing cGMP levels. Recent medical research and development studies resulted in the production of indazole derivatives for the treatment of osteoporosis, inflammatory diseases and neurodegenerative disorders. 4-bromo-1H indazole molecule is a much stronger inhibitor of 6-bromo-1H indazole and 7-bromo-1H indazole. 4-Bromo-1H-indazole may be strong inhibitor candidate for LPO and that caution should be exercised when using medicines containing indazole derivatives[1].
Chemical Properties
brown powder
Synthesis
To N-Acetyl-4-bromo-1H-indazole (1.6 g, 6.69 mmol) was added methanol (25.9 mL) and then 6 N HCl (15.6 mL). The resulting solution was stirred at room temperature until the reaction was completed after 7 h (monitored by TLC, petroleum ether/ethyl acetate 2:1). After evaporation of methanol in vacuo, the residue was extracted with ethyl acetate (50 mL*3). The combined organic layers were dried over anhydrous Na2SO4 and concentrated in vacuo. The crude was purified by flash chromatography (petroleum ether/ethyl acetate, 5:1) to yield 4-bromo-1H-indazole (0.8 g) as milky white solid, mp 164–166°C, yield 67.1%[2].
References
[1] Koksal Z, et al. Lactoperoxidase, an antimicrobial enzyme, is inhibited by some indazoles. Drug and Chemical Toxicology, 2018; 43: 22-26.
[2] Wang Y, et al. Synthesis and Antibacterial Activity of Novel 4-Bromo-1H-Indazole Derivatives as FtsZ Inhibitors. Archiv der Pharmazie, 2015; 348: 266-274.
4-Bromo-1H-indazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-1H-indazole manufacturers
- Product
- 4-Bromoindazole 186407-74-9
- Price
- US $950.00/g
- Min. Order
- 1g
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-03-19
- Product
- 4-BROMO (1H)INDAZOLE 186407-74-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2023-03-07
- Product
- 4-BROMO (1H)INDAZOLE 186407-74-9
- Price
- US $20.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 50000tons
- Release date
- 2023-08-15