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REVEROMYCIN A

Product Name
REVEROMYCIN A
CAS No.
134615-37-5
Chemical Name
REVEROMYCIN A
Synonyms
REVEROMYCIN A;ZESGNAJSBDILTB-OXVOKJAASA-N;Butanedioic acid, 1-[(2S,3R,6S,8R,9S)-3-butyl-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadien-1-yl]-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] ester
CBNumber
CB4443481
Molecular Formula
C36H52O11
Formula Weight
660.79
MOL File
134615-37-5.mol
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REVEROMYCIN A Property

Boiling point:
849.0±65.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMF: soluble
form 
solid
pka
4.36±0.17(Predicted)
color 
tan
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R0654
Product name
Reveromycin A
Purity
solid
Packaging
100μg
Price
$341
Updated
2024/03/01
Cayman Chemical
Product number
17458
Product name
Reveromycin A
Purity
≥99%
Packaging
250μg
Price
$353
Updated
2024/03/01
Cayman Chemical
Product number
17458
Product name
Reveromycin A
Purity
≥99%
Packaging
1mg
Price
$704
Updated
2024/03/01
TRC
Product number
R279910
Product name
Reveromycin A
Packaging
250μg
Price
$305
Updated
2021/12/16
Usbiological
Product number
464650
Product name
Reveromycin A
Packaging
100μg
Price
$453
Updated
2021/12/16
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REVEROMYCIN A Chemical Properties,Usage,Production

Uses

Reveromycin A, the dominant analogue of a complex of spiroketals isolated from a Streptomyces sp., is an inhibitor of the mitogenic activity of EGF. Reveromycin A is a G1 phase cell cycle inhibitor, selectively inhibiting isoleucyl-tRNA synthetase. Reveromycin A displays antiproliferative behaviour against human cell lines KB and K562, as well as potent antifungal activity. More recently it has been shown to induce apoptosis in osteoclasts thus inhibiting bone resorption.

Uses

Reveromycin A is a spiroketal antibiotic inhibitor of EGF mitogenic activity. Inhibits the signal transduction of the epidermal growth factor. May be used

REVEROMYCIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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REVEROMYCIN A Suppliers

China 43 India 1 Switzerland 1 United Kingdom 4 United States 11 Global 60
SIGMA-RBI
Tel
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Country
Switzerland
ProdList
6896
Advantage
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134615-37-5, REVEROMYCIN ARelated Search:

L-MIMOSINE VERRUCULOGEN Vinblastine sulfate S-Trityl-L-cysteine Morin hydrate Tangeretin MALVIDIN CHLORIDE TRYPROSTATIN A (E,E)-2,4-Dodecadienal FEMA 3766 1,1-DI(2-METHYLBUTOXY)ETHANE REVEROMYCIN A ACETIC ACID 2-METHYL-4-PENTEN-2-YL ESTER REVEROMYCIN D REVEROMYCIN C REVEROMYCIN B (-)-Reveromycin B, Synthetic (-)-REVEROMYCIN B

  • REVEROMYCIN A
  • ZESGNAJSBDILTB-OXVOKJAASA-N
  • Butanedioic acid, 1-[(2S,3R,6S,8R,9S)-3-butyl-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadien-1-yl]-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] ester
  • 134615-37-5
  • C36H52O11
  • BioChemical
  • Antibiotics
  • Antibiotics A to Z
  • Antibiotics N-S
  • Epidermal Growth Factor Receptor (EGFR)Antibiotics
  • Interferes with Protein Synthesis
  • Antibiotics
  • Antibiotics A to
  • Antibiotics by Application
  • Antibiotics N-SAntibiotics
  • AntifungalAntibiotics
  • Mechanism of Action
  • Receptor Tyrosine Kinase Inhibitors
  • Spectrum of Activity
  • Antineoplastic and Immunosuppressive AntibioticsReceptor Tyrosine Kinase Biology