ChemicalBook > CAS DataBase List > 18-Crown-6

18-Crown-6

Product Name
18-Crown-6
CAS No.
17455-13-9
Chemical Name
18-Crown-6
Synonyms
1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE;8-Crown-6;HEXAOXACYCLOOCTADECANE;18-CROWN 6-ETHER;Ethylene oxide cyclic hexamer;18-Crown ether-6;18-CROWN-6;NSC 159836;18-Crown-6 99%;18-Crown-6,99%
CBNumber
CB4445218
Molecular Formula
C12H24O6
Formula Weight
264.32
MOL File
17455-13-9.mol
More
Less

18-Crown-6 Property

Melting point:
42-45 °C(lit.)
Boiling point:
116°C 0,2mm
Density 
1,175 g/cm3
refractive index 
1.4580 (estimate)
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
Chloroform (Slightly), Methanol (Very Slightly)
form 
Crystals or Crystalline Mass or Liquid
color 
White or clear colorless
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
Merck 
14,2602
BRN 
1619616
Stability:
Stable. Incompatible with strong acids, strong oxidizing agents.
InChIKey
XEZNGIUYQVAUSS-UHFFFAOYSA-N
CAS DataBase Reference
17455-13-9(CAS DataBase Reference)
NIST Chemistry Reference
1,4,7,10,13,16-Hexaoxacyclooctadecane(17455-13-9)
EPA Substance Registry System
1,4,7,10,13,16-Hexaoxacyclooctadecane (17455-13-9)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38-36-20/22-20/21/22
Safety Statements 
26-36-39
RIDADR 
2811
WGK Germany 
3
RTECS 
MP4500000
F 
10
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29329995
Toxicity
LD50 orally in Rabbit: 525 mg/kg LD50 dermal Rabbit 3888 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.11684
Product name
Crown ether/18-Crown-6
Purity
for synthesis
Packaging
2g
Price
$26.1
Updated
2024/03/01
Sigma-Aldrich
Product number
8.11684
Product name
Crown ether/18-Crown-6
Purity
for synthesis
Packaging
5G
Price
$33.3
Updated
2024/03/01
Sigma-Aldrich
Product number
8.11684
Product name
Crown ether/18-Crown-6
Purity
for synthesis
Packaging
25g
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
28125
Product name
18-Crown-6
Purity
purum, ≥99.0% (GC)
Packaging
5g
Price
$46.5
Updated
2024/03/01
Sigma-Aldrich
Product number
186651
Product name
18-Crown-6
Purity
99%
Packaging
5G
Price
$113
Updated
2024/03/01
More
Less

18-Crown-6 Chemical Properties,Usage,Production

Chemical Properties

slightly yellow solid

Uses

A useful phase transfer catalyst.

Uses

18-Crown-6 is used as an efficient phase transfer catalyst and as a complexing agent with a variety of small cation. It is involved in the synthesis of diaryl ethers, diaryl thioethers, and diarylamines mediated by potassium fluoride-alumina and 18-crown-6. It facilitates the solubility of potassium permanganate in benzene, which is used for oxidizing the organic compounds. It is used to accelerate various substitution reactions as well as enhances the power of nucleophiles such as potassium acetate. It is utilized in the alkylation reactions in the presence of potassium carbonate, N-alkylation of glutarimide and succinimide with dimethylcarbonate. The complex formed by its reaction with potassium cyanide acts as a catalyst in the cyanosilylation of aldehydes, ketones and quinines with trimethylsilyl cyanide (TMSCN).

Uses

18-Crown-6 may be used to catalyze the N-alkylation of heterocyclic compounds and allylation of functionalized aldehydes.

Definition

ChEBI: 18-crown-6 is a crown ether that is cyclooctadecane in which the carbon atoms at positions 1, 4, 7, 10, 13 and 16 have been replaced by oxygen atoms. It has a role as a phase-transfer catalyst. It is a crown ether and a saturated organic heteromonocyclic parent.

Synthesis Reference(s)

The Journal of Organic Chemistry, 39, p. 2445, 1974 DOI: 10.1021/jo00930a037

General Description

18-Crown-6 is the simplest crown ether that can be prepared by reacting triethylene glycol with triethylene glycol dichloride in the presence of potassium hydroxide as a base. 18-Crown-6 can solubilize metal salts, particularly potassium salts, in nonpolar and dipolar aprotic solvents. Thus, it is widely used as a phase transfer catalyst. It can also be used as a metal complexing agent to prepare a variety of molecular complexes.

Purification Methods

Recrystallise it from acetonitrile and dry it in a vacuum. Purify it also by precipitating the 18-crown-6/nitromethane 1:2 complex with Et2O/nitromethane (10:1 mixture). The complex is decomposed in vacuum whereby 18-crown-6 distils off under the reduced pressure. [Beilstein 19/12 V 601.]

18-Crown-6 Preparation Products And Raw materials

Raw materials

Organic base GLOBULINS, CAT GAMMA Biochemistry Alkali Metals, plasma standard solution, Specpure, Ba,Be,Ca,Cs,K,Li,Mg,Na,Rb,Sr, 100μg/ml POTASSIUM CYANIDE 15-Crown-5

Preparation Products

[(2-OXO-2H-CHROMEN-7-YL)OXY]ACETIC ACID 5-AMINOMETHYL-PYRROLIDIN-2-ONE 5-Bromoindazole 3-AMINO-2-FLUORO-4-PICOLINE 1,2-EPOXYCYCLODODECANE Cefpodoxime proxetil 4-AMINO-2,6-DIFLUOROPYRIMIDINE 1,1'-DIMETHYLFERROCENE N,N-Dimethylethylenediamine 2-(4-BROMOPHENYL)THIOPHENE 3-PHENOXYPHENYLACETONITRILE 2,4-DIAMINO-6-FLUOROPYRIMIDINE 2-AMINO-4,6-DIFLUOROPYRIMIDINE 1,3-THIAZOLIDIN-2-ONE N,N,N',N'-Tetraphenylbenzidine
More
Less

18-Crown-6 Suppliers

Americas 1 Belgium 1 Canada 4 China 516 Czech 1 Europe 4 France 1 Germany 6 India 68 Japan 7 Russia 1 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 21 United States 61 Global 698
Jiangsu laurel Pharma Co., Ltd
Tel
0517-83966898 15861782979
Email
32860091@qq.com
Country
China
ProdList
294
Advantage
58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
133-96369453 18678026865
Fax
0536-2101172
Email
sdfantai@163.com
Country
China
ProdList
852
Advantage
58
Shanghai Chang-Gen Chemical Technology Co., Ltd.
Tel
021-69106814 13917161715
Email
3007500651@qq.com
Country
China
ProdList
79
Advantage
60
Shandong Mantang Hongxin Material Co. , Ltd.
Tel
0531-88770911 15165133308
Email
277033665@qq.com
Country
China
ProdList
204
Advantage
58
Aikon International Limited
Tel
025-66028182 18112977050
Fax
(3)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
15820
Advantage
58
Jinan Trands Chemical Co. LTD
Tel
0531-88770911 15154153272
Fax
0531-88770911
Email
1343989492@qq.com
Country
China
ProdList
111
Advantage
58
Nanjing Yihua Biotechnology Co., Ltd
Tel
15850730945; 15850730945
Email
1334103687@qq.com
Country
China
ProdList
286
Advantage
58
Hubei Taihechang Biotechnology Co., Ltd
Tel
18607169902 18607169902
Email
18607169902@163.com
Country
China
ProdList
2425
Advantage
58
Creasyn Finechem(Tianjin) Co., Ltd.
Tel
022-022-83946278 13820372920
Fax
022-83945176
Email
sales@creasyn.com
Country
China
ProdList
994
Advantage
68
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1998
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Suzhou Chireach Biomedical Technology Co., Ltd.
Tel
0512-65856968
Fax
0512-65647218
Email
sales@chireach.com
Country
China
ProdList
60
Advantage
70
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1392
Advantage
62
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18501085097
Fax
010-89508210
Email
sales3.gd@hwrkchemical.com
Country
China
ProdList
7583
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12458
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9551
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11660
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9816
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17987
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3296
Advantage
57
Shandong Xiya Chemical Co., Ltd
Tel
13355009207 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18739
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
Tangshan Moneide Trading Co., Ltd.
Tel
0315-8309571 15633399667
Fax
+86-315-7726572
Email
sales@moneidechem.com
Country
China
ProdList
704
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
+8618575662672 18575662672
Fax
021 51613951
Email
mzeng@3wpharm.com
Country
China
ProdList
9747
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4550
Advantage
62
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4388
Advantage
65
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11714
Advantage
57
Explovisual Technology Incorporation
Tel
+86 (519) 8829-2061
Fax
+86 (519) 8829-2061
Email
explovisual@hotmail.com
Country
China
ProdList
296
Advantage
60
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4941
Advantage
60
PharmSyn CO.,LTD
Tel
0512-65218020 18261037325
Email
biz@pharmsyn.com
Country
China
ProdList
80
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6139
Advantage
55
Yurui (Shanghai) Chemical Co., Ltd.
Tel
02150456736 13818239876
Fax
021-50761379
Email
xin@riyngroup.com
Country
China
ProdList
1136
Advantage
30
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19918
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
021-50430803 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9352
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18216
Advantage
56
More
Less

View Lastest Price from 18-Crown-6 manufacturers

Hunan aslsen technology co.,ltd
Product
18-Crown-6 17455-13-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-04-02
Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
18-Crown-6 17455-13-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99.6%
Supply Ability
100000
Release date
2024-04-24
Henan Fengda Chemical Co., Ltd
Product
18-Crown-6 17455-13-9
Price
US $8.00-0.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-22

17455-13-9, 18-Crown-6 Related Search:

Dimethyl ether 2-Butoxyethanol Ethylbenzene 12-Crown-4 Octadecane 4'' 4 (5 )-DI-TERT.BUTYLDICYCLOHEXANO-18-CROWN-6,MIXTUREOFISOMERS (+)-(18-CROWN-6)-2,3,11,12-TETRACARBOXYLIC ACID Diethyl ether Dicyclohexano-18-crown-6 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE-2-METHANOL 4-ACRYLAMIDOBENZO-18-CROWN-6 98% Isobutyl iodide 4',4''(5'')-di-tert-butyldibenzo-18-crown-6, mixed isomers,4,4'-Di-tert-butyldibenzo-18-crown-6 4-AMINOBENZO-18-CROWN-6 PURUM,97% 4-Nitrobenzo-18-crown-6,99% 4-VINYLBENZO-18-CROWN-6 97% 4-(Chloromethyl)styrene homopolymer Dibenzo-18-crown-6,min.98%,1,4,7,14,17,20-HEXAOXA[7.7]ORTHOCYCLOPHANE<BR> DIBENZO-18-CROWN-6,Dibenzo-18-crown-6, 98+%

  • 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE
  • 18-CROWN 6-ETHER
  • 18-CROWN-6
  • HEXAOXACYCLOOCTADECANE
  • CROWN-18-5-ETHER
  • CROWN ETHER/18-CROWN-6
  • AKOS BBS-00004361
  • JACS-17455-13-9
  • CROWN ETHER/18-CROWN-6 FOR SYNTHESIS
  • 18 and crown ether
  • 18-Crown-6 >=99.0%
  • 18-Crown-6 99%
  • 18-Crown-6 puruM, >=99.0% (GC)
  • 18 - the chaMpions league - 6 - ether
  • 1,4,7,10,13,16-Hexaoxacyclooctadecane 99%
  • 8-Crown-6
  • 1,4,7,1,13,16-Hexaoxacyclooctadecane
  • 18-CROWN-6, 99.5+%
  • 18-CROWN-6(1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE)
  • 18-Crown-6, 98+%
  • 1,4,7,10,13,16-HEXOXA-CYCLO-OCTADECANE
  • 18-Crown-6,99%
  • 1,4,7,10,13,16-Hexanoxacyclooctadecane.
  • 18-Crown-6-ether 99%
  • 1,4,7,10,13,16-Hexaoxacyclooctadecane (18-Crown-6)
  • 18-CROWN-6 99.8%
  • Crown/18-crown-6
  • 1,4,7,10,13,16-Hexaoxacyclooctadecane, Hexaoxacyclooctadecane
  • 18-Crown ether-6
  • 18-CROWN-6-ETHER pure
  • Ethylene oxide cyclic hexamer
  • NSC 159836
  • 18-Crown-6/1,4,7,10,13,16-HexaoxacyclooCLadecane
  • 18-Crown-6, 99% 25GR
  • 18-Crown-6, 99% 5GR
  • 18-Crown-6 solution
  • 18-Crown-6, 99%, reagent grade
  • 18-Crown 6-Ether &gt
  • 18-Crown-6（1,4,7,10,13,17-Hexaoxacyclooctadecane）,>99%
  • 18-Crown-6（1,4,7,10,13,18-Hexaoxacyclooctadecane）,>99%
  • High quality 18-Crown-6 CAS 17455-13-9 Crown Ether
  • 18-Crown 6-Ether, ≥ 98.0%
  • N,N-Diethylformamide 617-84-5
  • 18-Crown-8-Ether
  • Octadecyl hexaether
  • 18-Crown-6 1,4,7,10,13,16-Hexaoxacyclooctadecane (1,4,7,10,13,16-hexaoxacyclooctadecane) Crownwhitextl 18-Crown-6-ether
  • 17455-13-9
  • 7455-13-9
  • C12H24O6
  • Synthetic Reagents
  • Trace Analysis Reagents
  • General Use
  • Macrocycles for Host-Guest Chemistry
  • Crown Ethers
  • Analytical Reagents
  • Analytical Chromatography Product Catalog
  • Chelation/Complexation Compounds
  • crown ether