(S)-(-)-PROPRANOLOL HYDROCHLORIDE

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(S)-(-)-PROPRANOLOL HYDROCHLORIDE

Product Name: (S)-(-)-PROPRANOLOL HYDROCHLORIDE
CAS No.: 4199-10-4
Chemical Name: (S)-(-)-PROPRANOLOL HYDROCHLORIDE
Synonyms: S-PROPANOLOL;S(-)-PROPRANOLOL HCL;S-(-)-PROPANOLOL HCL;l-Propranolol chlorhydrate;l-Propranolol hydrochloride;(S)-PROPRANOLOL HYDROCHLORIDE;Levopropranolol hydrochloride;2S-(-)-PROPANOLOL HYDROCHLORIDE;L-(-)-Propranolol hydrochloride;(S)-(-)-PROPRANOLOL HYDROCHLORIDE
CBNumber: CB4455695
Molecular Formula: C16H22ClNO2
Formula Weight: 295.8
MOL File: 4199-10-4.mol

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(S)-(-)-PROPRANOLOL HYDROCHLORIDE Property

Melting point:: 193-195 °C(lit.)
storage temp.: 2-8°C
solubility: ethanol: 10 mg/mL
form: powder
color: White to off-white
optical activity: [α]25/D 25.5°, c = 1.0 in ethanol(lit.)
Water Solubility: Soluble to 100 mM in water
BRN: 3574966
InChIKey: ZMRUPTIKESYGQW-UQKRIMTDSA-N
CAS DataBase Reference: 4199-10-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P8688
Product name: (S)-(?)-Propranolol hydrochloride
Purity: ≥98% (TLC), powder
Packaging: 100mg
Price: $111
Updated: 2024/03/01

Sigma-Aldrich

Product number: P8688
Product name: (S)-(?)-Propranolol hydrochloride
Purity: ≥98% (TLC), powder
Packaging: 500mg
Price: $449
Updated: 2024/03/01

Cayman Chemical

Product number: 17291
Product name: (S)-(-)-Propranolol (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 17291
Product name: (S)-(-)-Propranolol (hydrochloride)
Purity: ≥98%
Packaging: 100mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 17291
Product name: (S)-(-)-Propranolol (hydrochloride)
Purity: ≥98%
Packaging: 250mg
Price: $161
Updated: 2024/03/01

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(S)-(-)-PROPRANOLOL HYDROCHLORIDE Chemical Properties,Usage,Production

Description

(S)-(-)-Propranolol is the active enantiomer of propranolol, a β-adrenergic receptor antagonist with log K_d values of -8.16, -9.08, and -6.93 for β₁, β₂, and β₃, respectively. It is also a non-specific serotonin receptor antagonist. Propanolol was one of the first β-adrenergic receptor blockers to be widely used in clinical practice for the treatment of hypertension, angina pectoris, and cardiac ischemia.

Chemical Properties

(S)-(-)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride

Uses

Antihypertensor;Beta-adrenergic blocking agent

Uses

The S-enantiomer of Propranolol (P831800). β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).

Uses

active enantiomer, 5-HT1 receptor antagonist

Biological Activity

More active enantiomer of the β -adrenoceptor antagonist propranolol ((RS)-1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol hydrochloride ).

Biochem/physiol Actions

(S)-(?)-Propranolol hydrochloride is biologically active enantiomer. It acts as β1 receptor antagonist in thalamocortical neurons. (S)-(?)-Propranolol hydrochloride elicits its inhibitory function on the β1 adrenoceptor in trigeminovascular pain pathway and serves as a preventive medicine in migraine.

storage

Store at RT

Purification Methods

The (+)-salt is the active isomer which blocks isoprenaline tachycardia and is a -adrenergic blocker. [Leclerc et al. Trends Pharmacol Sci 2 18 1981, Howe & Shanks Nature 210 1336 1966.]

(S)-(-)-PROPRANOLOL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(-)-PROPRANOLOL HYDROCHLORIDE Suppliers

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View Lastest Price from (S)-(-)-PROPRANOLOL HYDROCHLORIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: (S)-(-)-Propranolol hydrochloride 4199-10-4
Price: US $1.00-45.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-08-01

Baoji Guokang Healthchem co.,ltd

Product: (S)-(-)-PROPRANOLOL HYDROCHLORIDE 4199-10-4
Price: US $166.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 2000KG
Release date: 2021-06-04

4199-10-4, (S)-(-)-PROPRANOLOL HYDROCHLORIDERelated Search:

1-ETHOXYNAPHTHALENE (RS)-Propranolol hydrochloride,Propranolol Hydrochloride for pharmaceutical raw materials,DL-PROPRANOLOL HYDROCHLORIDE (S)-(-)-PROPRANOLOL HYDROCHLORIDE Propanolol 3-AMINO-1-PHENOXY-2-PROPANOL HYDROCHLORIDE, 98 2-(1-NAPHTHYLOXY) ETHANOL Propranolol hydrochloride R(+)-PROPRANOLOL HYDROCHLORIDE >98% (R)-4-Hydroxy Propranolol Hydrochloride,(S)-4-Hydroxy Propranolol Hydrochloride d-Propranolol hydrochloride,(R)-(+)-PROPRANOLOL HYDROCHLORIDE,(R)-PROPRANOLOL HYDROCHLORIDE (S)-3-AMINO-1,2-DIHYDROXYPROPANE HYDROCHLORIDE CHEMBRDG-BB 5482082 1-METHYLAMINO-3-PHENOXY-PROPAN-2-OL AKOS BBS-00007965 (S)-3-ISOPROPYLAMINO-1,2-PROPANEDIOL 3-phenoxy-1-propanamine (S)-N-DESISOPROPYLPROPRANOLOL 1-AMINO-3-PHENOXY-PROPAN-2-OL

(S)-(-)-1-[(1-METHYLETHYL)AMINO]-3-(1-NAPHTHALENYLOXY)-2-PROPANOL HYDROCHLORIDE

(S)-1-ISOPROPYLAMINO-3-(1-NAPHTHYLOXY)-2-PROPANOL HYDROCHLORIDE

S-(-)-PROPANOLOL HCL

S(-)-PROPRANOLOL HCL

(S)-(-)-PROPRANOLOL HYDROCHLORIDE

(S)-PROPRANOLOL HYDROCHLORIDE

2S-(-)-PROPANOLOL HYDROCHLORIDE

(S)-[2-hydroxy-3-(naphthyloxy)propyl]isopropylammonium chloride

2-Propanol, 1-(1-methylethyl)amino-3-(1-naphthalenyloxy)-, hydrochloride, (2S)-

2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (2S)- (9CI)

2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (S)-

L-(-)-Propranolol hydrochloride

l-Propranolol chlorhydrate

l-Propranolol hydrochloride

S-(-)-1-Isopropylamino-3-(1-naphthoxy)-2-propanol hydrochloride

S-PROPANOLOL

(S)-1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride

(S)-(-)-1-(1-Methylethylamino)-3-naphthalen-1-yloxy-propan-2-ol hydrochloride

(2S)-1-(1-Naphtyloxy)-3-(isopropylamino)-2-propanol·hydrochloric acid

(2S)-1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol hydrochloride

(2S)-1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol hydrochloride

(S)-()-Propranolol hydrochloride,(S)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride

(2S)-(-)-Propanolol Hydrochloride≥ 95% (NMR)

(S)()Propranolol hydrochloride,(S) ( ) Propranolol hydrochloride

Levopropranolol hydrochloride

4199-10-4

C16H22ClNO2

Asymmetric Synthesis

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