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(S)-(-)-PROPRANOLOL HYDROCHLORIDE

Product Name
(S)-(-)-PROPRANOLOL HYDROCHLORIDE
CAS No.
4199-10-4
Chemical Name
(S)-(-)-PROPRANOLOL HYDROCHLORIDE
Synonyms
S-PROPANOLOL;S(-)-PROPRANOLOL HCL;S-(-)-PROPANOLOL HCL;l-Propranolol chlorhydrate;l-Propranolol hydrochloride;(S)-PROPRANOLOL HYDROCHLORIDE;Levopropranolol hydrochloride;2S-(-)-PROPANOLOL HYDROCHLORIDE;L-(-)-Propranolol hydrochloride;(S)-(-)-PROPRANOLOL HYDROCHLORIDE
CBNumber
CB4455695
Molecular Formula
C16H22ClNO2
Formula Weight
295.8
MOL File
4199-10-4.mol
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(S)-(-)-PROPRANOLOL HYDROCHLORIDE Property

Melting point:
193-195 °C(lit.)
storage temp. 
2-8°C
solubility 
ethanol: 10 mg/mL
form 
powder
color 
White to off-white
optical activity
[α]25/D 25.5°, c = 1.0 in ethanol(lit.)
Water Solubility 
Soluble to 100 mM in water
BRN 
3574966
InChIKey
ZMRUPTIKESYGQW-UQKRIMTDSA-N
CAS DataBase Reference
4199-10-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P8688
Product name
(S)-(?)-Propranolol hydrochloride
Purity
≥98% (TLC), powder
Packaging
100mg
Price
$111
Updated
2024/03/01
Sigma-Aldrich
Product number
P8688
Product name
(S)-(?)-Propranolol hydrochloride
Purity
≥98% (TLC), powder
Packaging
500mg
Price
$449
Updated
2024/03/01
Cayman Chemical
Product number
17291
Product name
(S)-(-)-Propranolol (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
17291
Product name
(S)-(-)-Propranolol (hydrochloride)
Purity
≥98%
Packaging
100mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
17291
Product name
(S)-(-)-Propranolol (hydrochloride)
Purity
≥98%
Packaging
250mg
Price
$161
Updated
2024/03/01
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(S)-(-)-PROPRANOLOL HYDROCHLORIDE Chemical Properties,Usage,Production

Description

(S)-(-)-Propranolol is the active enantiomer of propranolol, a β-adrenergic receptor antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively. It is also a non-specific serotonin receptor antagonist. Propanolol was one of the first β-adrenergic receptor blockers to be widely used in clinical practice for the treatment of hypertension, angina pectoris, and cardiac ischemia.

Chemical Properties

(S)-(-)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride

Uses

Antihypertensor;Beta-adrenergic blocking agent

Uses

The S-enantiomer of Propranolol (P831800). β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).

Uses

active enantiomer, 5-HT1 receptor antagonist

Biological Activity

More active enantiomer of the β -adrenoceptor antagonist propranolol ((RS)-1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol hydrochloride ).

Biochem/physiol Actions

(S)-(?)-Propranolol hydrochloride is biologically active enantiomer. It acts as β1 receptor antagonist in thalamocortical neurons. (S)-(?)-Propranolol hydrochloride elicits its inhibitory function on the β1 adrenoceptor in trigeminovascular pain pathway and serves as a preventive medicine in migraine.

storage

Store at RT

Purification Methods

The (+)-salt is the active isomer which blocks isoprenaline tachycardia and is a -adrenergic blocker. [Leclerc et al. Trends Pharmacol Sci 2 18 1981, Howe & Shanks Nature 210 1336 1966.]

(S)-(-)-PROPRANOLOL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(-)-PROPRANOLOL HYDROCHLORIDE Suppliers

Canada 1 China 62 Europe 1 Germany 3 India 2 Japan 1 Switzerland 1 Ukraine 1 United Kingdom 6 United States 14 Global 92
Nacalai Tesque, Inc.
Tel
--
Fax
--
Email
info-tech@nacalai.co.jp
Country
Japan
ProdList
6046
Advantage
75
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View Lastest Price from (S)-(-)-PROPRANOLOL HYDROCHLORIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
(S)-(-)-Propranolol hydrochloride 4199-10-4
Price
US $1.00-45.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-08-01
Baoji Guokang Healthchem co.,ltd
Product
(S)-(-)-PROPRANOLOL HYDROCHLORIDE 4199-10-4
Price
US $166.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
2000KG
Release date
2021-06-04

4199-10-4, (S)-(-)-PROPRANOLOL HYDROCHLORIDERelated Search:

1-ETHOXYNAPHTHALENE (RS)-Propranolol hydrochloride,Propranolol Hydrochloride for pharmaceutical raw materials,DL-PROPRANOLOL HYDROCHLORIDE (S)-(-)-PROPRANOLOL HYDROCHLORIDE Propanolol 3-AMINO-1-PHENOXY-2-PROPANOL HYDROCHLORIDE, 98 2-(1-NAPHTHYLOXY) ETHANOL Propranolol hydrochloride R(+)-PROPRANOLOL HYDROCHLORIDE >98% (R)-4-Hydroxy Propranolol Hydrochloride,(S)-4-Hydroxy Propranolol Hydrochloride d-Propranolol hydrochloride,(R)-(+)-PROPRANOLOL HYDROCHLORIDE,(R)-PROPRANOLOL HYDROCHLORIDE (S)-3-AMINO-1,2-DIHYDROXYPROPANE HYDROCHLORIDE CHEMBRDG-BB 5482082 1-METHYLAMINO-3-PHENOXY-PROPAN-2-OL AKOS BBS-00007965 (S)-3-ISOPROPYLAMINO-1,2-PROPANEDIOL 3-phenoxy-1-propanamine (S)-N-DESISOPROPYLPROPRANOLOL 1-AMINO-3-PHENOXY-PROPAN-2-OL

  • (S)-(-)-1-[(1-METHYLETHYL)AMINO]-3-(1-NAPHTHALENYLOXY)-2-PROPANOL HYDROCHLORIDE
  • (S)-1-ISOPROPYLAMINO-3-(1-NAPHTHYLOXY)-2-PROPANOL HYDROCHLORIDE
  • S-(-)-PROPANOLOL HCL
  • S(-)-PROPRANOLOL HCL
  • (S)-(-)-PROPRANOLOL HYDROCHLORIDE
  • (S)-PROPRANOLOL HYDROCHLORIDE
  • 2S-(-)-PROPANOLOL HYDROCHLORIDE
  • (S)-[2-hydroxy-3-(naphthyloxy)propyl]isopropylammonium chloride
  • 2-Propanol, 1-(1-methylethyl)amino-3-(1-naphthalenyloxy)-, hydrochloride, (2S)-
  • 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (2S)- (9CI)
  • 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (S)-
  • L-(-)-Propranolol hydrochloride
  • l-Propranolol chlorhydrate
  • l-Propranolol hydrochloride
  • S-(-)-1-Isopropylamino-3-(1-naphthoxy)-2-propanol hydrochloride
  • S-PROPANOLOL
  • (S)-1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride
  • (S)-(-)-1-(1-Methylethylamino)-3-naphthalen-1-yloxy-propan-2-ol hydrochloride
  • (2S)-1-(1-Naphtyloxy)-3-(isopropylamino)-2-propanol·hydrochloric acid
  • (2S)-1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol hydrochloride
  • (2S)-1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol hydrochloride
  • (S)-()-Propranolol hydrochloride,(S)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride
  • (2S)-(-)-Propanolol Hydrochloride≥ 95% (NMR)
  • (S)()Propranolol hydrochloride,(S) ( ) Propranolol hydrochloride
  • Levopropranolol hydrochloride
  • 4199-10-4
  • C16H22ClNO2
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • Amino Alcohols
  • Organic Building Blocks
  • Adrenoceptor
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals