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OUABAIN OCTAHYDRATE

Product Name
OUABAIN OCTAHYDRATE
CAS No.
11018-89-6
Chemical Name
OUABAIN OCTAHYDRATE
Synonyms
Ouabain CRS;OUABAIN 8H2O;OUABAIN 8H20;G-Strophantin;STROPHANTHIN G;OUABAIN HYDRATE;OUBAIN OCTAHYDRATE;OUABAIN OCTAHYDRATE;(-)-OUABAIN OCTAHYDRATE;Ouabain octahydrate,96%
CBNumber
CB4469924
Molecular Formula
C29H60O20
Formula Weight
728.77
MOL File
11018-89-6.mol
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OUABAIN OCTAHYDRATE Property

Melting point:
260 °C
storage temp. 
room temp
solubility 
H2O: 10 mg/mL cold
form 
powder
color 
white
optical activity
[α]25/D 31 to 32.5° in H2O(lit.)
Water Solubility 
Soluble in water.
Sensitive 
Light Sensitive
BRN 
101712
Stability:
Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
EPA Substance Registry System
Card-20(22)-enolide, 3-[(6-deoxy-.alpha.-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-, octahydrate, (1.beta.,3.beta.,5.beta.,11.alpha.)- (11018-89-6)
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Safety

Hazard Codes 
T
Risk Statements 
23/25-33
Safety Statements 
45
RIDADR 
UN 1544 6.1/PG 1
WGK Germany 
3
RTECS 
RN3850000
8
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
O3125
Product name
Ouabain octahydrate
Purity
≥95% (HPLC), powder
Packaging
1g
Price
$178
Updated
2024/03/01
Sigma-Aldrich
Product number
4995
Product name
Ouabain, Octahydrate - CAS 11018-89-6 - Calbiochem
Purity
Inhibits Na+,K+-ATPase.
Packaging
1g
Price
$159
Updated
2024/03/01
Alfa Aesar
Product number
J60724
Product name
Ouabain octahydrate, 95%
Packaging
1g
Price
$285.65
Updated
2024/03/01
Sigma-Aldrich
Product number
O3125
Product name
Ouabain octahydrate
Purity
≥95% (HPLC), powder
Packaging
250mg
Price
$58.8
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1945
Product name
Ouabain
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
300mg
Price
$173
Updated
2024/03/01
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OUABAIN OCTAHYDRATE Chemical Properties,Usage,Production

Description

Ouabain (11018-89-6) is a selective inhibitor of Na+ K+-ATPase isolated from Strophanthus gratus.1 Endogenous ouabain is found in human circulation.2 Displays cardiotonic and diuretic activity. May be used to induce hypertensive rat model.3?Cell permeable and active in vivo.

Chemical Properties

white to off-white crystalline powder

Chemical Properties

Ouabain is a white crystalline solid.

Uses

A cardiac glycoside that inhibits Na(+)/K(+) ATPase. It regulates transcription of MDR (increase, Pgp) and MRP (increase MRP1 and decrease CFTR, cyctic fibrosis transport receptor or cAMP-activated Cl- channel) genes, also alters localization of MRP1.

Uses

antiarrhythmic, cardiotonic, hypertensive, Na/K ATPase inhibitor

Uses

5HT2 receptor antagonist

Uses

Ouabain octahydrate, is used as a tool to induce in vivo excitotoxicity. Ouabain, as well as other endogenous digitalis-like compounds, can down-regulate the expression of 14-3-3 proteins in rat lens.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Ouabain has its specific binding site on integral proteins of the plasma membrane. Heart disease is treated using ouabain derivatives. Increased ouabain production is observed during exercise in humans. Abnormally high levels of ouabain are indicated in congestive heart failure and hypertension. Ouabain signalling affects intracellular calcium levels, which is known to activate nuclear factor κB (NFκB).

Potential Exposure

Ouabain, similar to digitoxin, is used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter; enzyme inhibitor.

Shipping

UN1544 Alkaloids, solid, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

It crystallises from water as the octahydrate. Dry it at 130o. It decomposes at 190o when dry. Store it in the dark as it is light sensitive, but it is stable in air. Its solubility (g/100mL) in H2O is 1.3 (~25o), 20 (~100o), and in EtOH it is 1.0 (~25o) and 12.5 (~78o). It is highly TOXIC as it is an inhibitor of cation transport and of Na+ and K+ ATPase. [Beilstein 18/5 V 625.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.).

References

1) Silva et al. (2012), New insights into the regulation of Na+,K(+)-ATPase by ouabain; Int. Rev. Cell. Mol. Biol., 294 99 2) Dvela et al. (2012), Endogenous ouabain regulates cell viability; Am. J. Physiol. Cell, Physiol., 302 C442

OUABAIN OCTAHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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OUABAIN OCTAHYDRATE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19179
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
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Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
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Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55

11018-89-6, OUABAIN OCTAHYDRATERelated Search:


  • Ouabain octahydrate,96%
  • Ouabain octahydrate,1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside), Acocantherine, G-Strophanthin
  • STROPHANTHIN G
  • STROPHANTHIN G, OCTAHYDRATE
  • OUABAIN 8H20
  • OUABAIN 8H2O
  • OUABAIN HYDRATE
  • (-)-OUABAIN OCTAHYDRATE
  • OUABAIN OCTAHYDRATE
  • OUBAIN OCTAHYDRATE
  • 1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside)
  • Card-20(22)-enolide, 3-(6-deoxy-.alpha.-L-mannopyranosyl)oxy-1,5,11,14,19-pentahydroxy-, octahydrate, (1.beta.,3.beta.,5.beta.,11.alpha.)-
  • Acocantherine, G-Strophanthin, 1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside)
  • Ouabain octahydrate, 96% 1GR
  • G-Strophantin
  • (1β,3β,5β,11α)-3-[(6-Deoxy-α-L-Mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxycard-20(22)-enolide Octahydrate
  • G-STROPHANTHIN OCTAHYDRATE
  • G-STROPHANTIN OCTAHYDRATE
  • (1beta,3beta,5beta,11alpha)-3-[(6-Deoxy-alpha-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-card-20(22)-enolide octahydrate
  • Card-20(22)-enolide,3-[(6-deoxy-a-L-Mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-,hydrate (1:8), (1b,3b,5b,11a)-
  • Ouabain octahydrate 96%
  • Strophanthin glycosides G
  • 1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside) Acocantherine G-Strophanthin G-Strophantin octahydrate
  • Ouabain, Octahydrate - CAS 11018-89-6 - Calbiochem
  • Ouabain CRS
  • Ouabain Octahydrate (Acocantherine)
  • Card-20(22)-enolide, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-, hydrate (1:8), (1β,3β,5β,11α)-
  • (1β,3β,5β,11α)-3-[(6-deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-Card-20(22)-enolide hydrate (1:8)
  • Na+/K+ ATPase,Ouabain,Sodium potassium pump,inhibit,Inhibitor,Autophagy,Ouabain octahydrate
  • g-Strophanthin Octahydrate, ≥ 98.0%
  • 11018-89-6
  • C29H44O128H2O
  • C28H44O12x8H2O
  • Ion Channels
  • Lipids
  • Other Sodium Channel Modulators
  • Monovalent Ion Channels
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  • Conjugates
  • Cell Signaling and Neuroscience
  • BioChemical
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