OUABAIN OCTAHYDRATE

ChemicalBook > CAS DataBase List > OUABAIN OCTAHYDRATE

Product Name: OUABAIN OCTAHYDRATE
CAS No.: 11018-89-6
Chemical Name: OUABAIN OCTAHYDRATE
Synonyms: Ouabain CRS;OUABAIN 8H2O;OUABAIN 8H20;G-Strophantin;STROPHANTHIN G;OUABAIN HYDRATE;OUBAIN OCTAHYDRATE;OUABAIN OCTAHYDRATE;(-)-OUABAIN OCTAHYDRATE;Ouabain octahydrate,96%
CBNumber: CB4469924
Molecular Formula: C29H60O20
Formula Weight: 728.77
MOL File: 11018-89-6.mol

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OUABAIN OCTAHYDRATE Property

Melting point:: 260 °C
storage temp.: room temp
solubility: H₂O: 10 mg/mL cold
form: powder
color: white
optical activity: [α]25/D 31 to 32.5° in H2O(lit.)
biological source: plant seeds (Strophantus gratus)
Water Solubility: Soluble in water.
Sensitive: Light Sensitive
ε(extinction coefficient): 15.5 at 220nm in H2O at 1mM
BRN: 101712
Stability:: Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
EPA Substance Registry System: Card-20(22)-enolide, 3-[(6-deoxy-.alpha.-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-, octahydrate, (1.beta.,3.beta.,5.beta.,11.alpha.)- (11018-89-6)

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Safety

Hazard Codes: T
Risk Statements: 23/25-33
Safety Statements: 45
RIDADR: UN 1544 6.1/PG 1
WGK Germany: 3
RTECS: RN3850000
F: 8
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H373May cause damage to organs through prolonged or repeated exposure
Precautionary statements: P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: O3125
Product name: Ouabain octahydrate
Purity: ≥95% (HPLC), powder
Packaging: 1g
Price: $178
Updated: 2024/03/01

Sigma-Aldrich

Product number: 4995
Product name: Ouabain, Octahydrate - CAS 11018-89-6 - Calbiochem
Purity: Inhibits Na+,K+-ATPase.
Packaging: 1g
Price: $159
Updated: 2024/03/01

Alfa Aesar

Product number: J60724
Product name: Ouabain octahydrate, 95%
Packaging: 1g
Price: $285.65
Updated: 2024/03/01

Sigma-Aldrich

Product number: O3125
Product name: Ouabain octahydrate
Purity: ≥95% (HPLC), powder
Packaging: 250mg
Price: $58.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR1945
Product name: Ouabain
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 300mg
Price: $173
Updated: 2024/03/01

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OUABAIN OCTAHYDRATE Chemical Properties,Usage,Production

Description

Ouabain (11018-89-6) is a selective inhibitor of Na+ K+-ATPase isolated from Strophanthus gratus.1 Endogenous ouabain is found in human circulation.2 Displays cardiotonic and diuretic activity. May be used to induce hypertensive rat model.3?Cell permeable and active in vivo.

Chemical Properties

white to off-white crystalline powder

Chemical Properties

Ouabain is a white crystalline solid.

Uses

A cardiac glycoside that inhibits Na(+)/K(+) ATPase. It regulates transcription of MDR (increase, Pgp) and MRP (increase MRP1 and decrease CFTR, cyctic fibrosis transport receptor or cAMP-activated Cl- channel) genes, also alters localization of MRP1.

Uses

antiarrhythmic, cardiotonic, hypertensive, Na/K ATPase inhibitor

Uses

5HT2 receptor antagonist

Uses

Ouabain octahydrate, is used as a tool to induce in vivo excitotoxicity. Ouabain, as well as other endogenous digitalis-like compounds, can down-regulate the expression of 14-3-3 proteins in rat lens.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Ouabain has its specific binding site on integral proteins of the plasma membrane. Heart disease is treated using ouabain derivatives. Increased ouabain production is observed during exercise in humans. Abnormally high levels of ouabain are indicated in congestive heart failure and hypertension. Ouabain signalling affects intracellular calcium levels, which is known to activate nuclear factor κB (NFκB).

Potential Exposure

Ouabain, similar to digitoxin, is used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter; enzyme inhibitor.

Shipping

UN1544 Alkaloids, solid, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

It crystallises from water as the octahydrate. Dry it at 130o. It decomposes at 190o when dry. Store it in the dark as it is light sensitive, but it is stable in air. Its solubility (g/100mL) in H2O is 1.3 (~25o), 20 (~100o), and in EtOH it is 1.0 (~25o) and 12.5 (~78o). It is highly TOXIC as it is an inhibitor of cation transport and of Na+ and K+ ATPase. [Beilstein 18/5 V 625.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.).

References

1) Silva et al. (2012), New insights into the regulation of Na+,K(+)-ATPase by ouabain; Int. Rev. Cell. Mol. Biol., 294 99 2) Dvela et al. (2012), Endogenous ouabain regulates cell viability; Am. J. Physiol. Cell, Physiol., 302 C442

OUABAIN OCTAHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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OUABAIN OCTAHYDRATE Suppliers

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11018-89-6, OUABAIN OCTAHYDRATERelated Search:

Tetrabenazine WZB117 Geldanamycin-FITC Sulfasalazine STROPHANTHIDOL periplogenin Convallatoxol TERPIN MONOHYDRATE OUABAGENIN G-STROPHANTHIN CURARE L-Menthol OUABAIN OCTAHYDRATE (-)-TRANS-2-TERT-BUTYLCYCLOHEXANOL CIS-1,2-CYCLOHEXANEDIMETHANOL 2-HEPTYL-2-(HYDROXYMETHYL)-1,3-PROPANEDIOL 2-(TRANS-4-ETHYLCYCLOHEXYL)PROPANE-1,3-DIOL TRANS-TERPIN

Ouabain octahydrate,96%

Ouabain octahydrate,1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside), Acocantherine, G-Strophanthin

STROPHANTHIN G

STROPHANTHIN G, OCTAHYDRATE

OUABAIN 8H20

OUABAIN 8H2O

OUABAIN HYDRATE

(-)-OUABAIN OCTAHYDRATE

OUABAIN OCTAHYDRATE

OUBAIN OCTAHYDRATE

1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside)

Card-20(22)-enolide, 3-(6-deoxy-.alpha.-L-mannopyranosyl)oxy-1,5,11,14,19-pentahydroxy-, octahydrate, (1.beta.,3.beta.,5.beta.,11.alpha.)-

Acocantherine, G-Strophanthin, 1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside)

Ouabain octahydrate, 96% 1GR

G-Strophantin

(1β,3β,5β,11α)-3-[(6-Deoxy-α-L-Mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxycard-20(22)-enolide Octahydrate

G-STROPHANTHIN OCTAHYDRATE

G-STROPHANTIN OCTAHYDRATE

(1beta,3beta,5beta,11alpha)-3-[(6-Deoxy-alpha-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-card-20(22)-enolide octahydrate

Card-20(22)-enolide,3-[(6-deoxy-a-L-Mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-,hydrate (1:8), (1b,3b,5b,11a)-

Ouabain octahydrate 96%

Strophanthin glycosides G

1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside) Acocantherine G-Strophanthin G-Strophantin octahydrate

Ouabain, Octahydrate - CAS 11018-89-6 - Calbiochem

Ouabain CRS

Ouabain Octahydrate (Acocantherine)

Card-20(22)-enolide, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-, hydrate (1:8), (1β,3β,5β,11α)-

(1β,3β,5β,11α)-3-[(6-deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-Card-20(22)-enolide hydrate (1:8)

Na+/K+ ATPase,Ouabain,Sodium potassium pump,inhibit,Inhibitor,Autophagy,Ouabain octahydrate

g-Strophanthin Octahydrate, ≥ 98.0%

Ouabain octahydrate, Na+/K+ ATPase inhibitor

Ouabain octahydrate, 10 mM in DMSO

11018-89-6

C29H44O128H2O

C28H44O12x8H2O

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