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Methyl 4-(chloroformyl)butyrate

Product Name
Methyl 4-(chloroformyl)butyrate
CAS No.
1501-26-4
Chemical Name
Methyl 4-(chloroformyl)butyrate
Synonyms
Methyl 5-chloro-5-;Methyl 4-(chloroform;METHYL GLUTARYL CHLORIDE;METHYL 5-CHLORO-5-OXOVALERATE;CARBOMETHOXYL BUTYRYL CHLORIDE;METHYL 4-(CHLOROFORMYL)BUTYRATE;METHYL 5-CHLORO-5-OXOPENTANOATE;METHYL 5-CHLORO-5-OXOVALERATE,98%;Methyl 4-(Chlorocarbonyl)butyrate;Methyl 4-(chlorocarbonyl)butanoate
CBNumber
CB4480260
Molecular Formula
C6H9ClO3
Formula Weight
164.59
MOL File
1501-26-4.mol
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Methyl 4-(chloroformyl)butyrate Property

Boiling point:
110 °C/17 mmHg (lit.)
Density 
1.191 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.445(lit.)
Flash point:
180 °F
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform, Hexane
form 
Oil
color 
Clear Colourless
Water Solubility 
reacts
Sensitive 
Moisture Sensitive
BRN 
1762383
CAS DataBase Reference
1501-26-4(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45-24/25
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
F 
10-21
HazardClass 
8
PackingGroup 
II
HS Code 
2918300090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M35355
Product name
Glutaric acid monomethyl ester chloride
Purity
98%
Packaging
10g
Price
$107.35
Updated
2025/07/31
Sigma-Aldrich
Product number
M35355
Product name
Glutaric acid monomethyl ester chloride
Purity
98%
Packaging
50g
Price
$269.5
Updated
2025/07/31
TRC
Product number
M227420
Product name
Methyl4-(Chloroformyl)butyrate
Packaging
10g
Price
$130
Updated
2021/12/16
Matrix Scientific
Product number
139913
Product name
Methyl 5-chloro-5-oxopentanoate
Purity
95%+
Packaging
2.500g
Price
$215
Updated
2021/12/16
Matrix Scientific
Product number
139913
Product name
Methyl 5-chloro-5-oxopentanoate
Purity
95%+
Packaging
5g
Price
$323
Updated
2021/12/16
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Methyl 4-(chloroformyl)butyrate Chemical Properties,Usage,Production

Chemical Properties

clear colourless to light yellow liquid

Uses

Methyl 4-(Chloroformyl)butyrate is used in the synthesis of Leukotriene B4, a proinflammatory agent produced from leukocytes.

Synthesis

67-56-1

108-55-4

1501-26-4

1. 100 g (0.878 mol) of glutaric anhydride was dissolved in 50 mL of anhydrous methanol and heated to reflux for 1 h. 2. Upon completion of the reaction, unreacted methanol was removed by distillation under reduced pressure. 3. The reaction mixture was cooled to room temperature, and 200 mL of acetochloride was slowly added. 4. The reaction mixture was heated for 6 h., wherein after 2 h of heating the remaining dichloro sulfoxide.5. Finally, the fractions were dried at 96 °C to 98 °C/10 mmHg to give 124.2 g of methyl 4-chlorocarbonylbutyrate as a light yellow liquid in 86.4% yield.

References

[1] Patent: CN103864658, 2016, B. Location in patent: Paragraph 0056; 0057
[2] Tetrahedron Letters, 1984, vol. 25, # 39, p. 4371 - 4374
[3] Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, vol. 31, # 6, p. 915 - 923

Methyl 4-(chloroformyl)butyrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 4-(chloroformyl)butyrate Suppliers

Belgium 1 Canada 1 China 138 Germany 2 India 2 Japan 2 Slovakia 1 Switzerland 1 Ukraine 1 United Kingdom 5 United States 19 Global 173
UkrOrgSynthesis Ltd.
Tel
--
Fax
--
Email
y.barysheva@ukrorgsynth.com
Country
Ukraine
ProdList
6230
Advantage
38
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View Lastest Price from Methyl 4-(chloroformyl)butyrate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Methyl 4-(chloroformyl)butyrate 1501-26-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Methyl 4-(chloroformyl)butyrate 1501-26-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
Methyl 4-(chloroformyl)butyrate 1501-26-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

1501-26-4, Methyl 4-(chloroformyl)butyrateRelated Search:

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  • METHYL 4-(CHLOROFORMYL)BUTYRATE 1501-26-4
  • Methyl 5-chloro-5-
  • 1501-26-4
  • ClCOCH23CO2CH3
  • ClCOCH23COOCH3
  • ACID CHLORIDE
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  • Acid Halides
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