ChemicalBook > CAS DataBase List > 4-Nitro-3-trifluoromethyl aniline

4-Nitro-3-trifluoromethyl aniline

Product Name: 4-Nitro-3-trifluoromethyl aniline
CAS No.: 393-11-3
Chemical Name: 4-Nitro-3-trifluoromethyl aniline
Synonyms: FLU-1;4-Nitro-α,α,α;TIMTEC-BB SBB006652;Flutamide Impurity A;Nilutamide Impurity 3;Nilutamide impurity B CRS;FlutaMide Related CoMpound A;Linagliptin Impurity CD10103;2-Nitro-5-aminobenzotriluoride;5-AMINO-2-NITROBENZOTRIFLUORIDE
CBNumber: CB4483928
Molecular Formula: C7H5F3N2O2
Formula Weight: 206.12
MOL File: 393-11-3.mol

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4-Nitro-3-trifluoromethyl aniline Property

Melting point:: 125-129 °C (lit.)
Boiling point:: 326.4±42.0 °C(Predicted)
Density: 1.4711 (estimate)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: -0.22±0.10(Predicted)
color: Yellow to Orange-Yellow
BRN: 2650702
InChI: InChI=1S/C7H5F3N2O2/c8-7(9,10)5-3-4(11)1-2-6(5)12(13)14/h1-3H,11H2
InChIKey: UTKUVRNVYFTEHF-UHFFFAOYSA-N
SMILES: C1(N)=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1
CAS DataBase Reference: 393-11-3(CAS DataBase Reference)
NIST Chemistry Reference: 5-Amino-2-nitrobenzotrifluoride(393-11-3)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36-36/37
WGK Germany: 2
Hazard Note: Irritant
HS Code: 29214200

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000894
Product name: Nilutamide impurity B
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 5 mg
Price: $118
Updated: 2025/07/31

Sigma-Aldrich

Product number: A68807
Product name: 4-Nitro-3-(trifluoromethyl)aniline
Purity: 98%
Packaging: 5g
Price: $103.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1285997
Product name: Flutamide Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 20mg
Price: $1300
Updated: 2025/07/31

TCI Chemical

Product number: A0377
Product name: 5-Amino-2-nitrobenzotrifluoride
Purity: >98.0%(GC)
Packaging: 5g
Price: $18
Updated: 2025/07/31

TCI Chemical

Product number: A0377
Product name: 5-Amino-2-nitrobenzotrifluoride
Purity: >98.0%(GC)
Packaging: 25g
Price: $60
Updated: 2025/07/31

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4-Nitro-3-trifluoromethyl aniline Chemical Properties,Usage,Production

Description

4-Nitro-3-trifluoromethyl aniline is an organic intermediate, which can be used to prepare 4-bromo-2-nitrotrifluorotoluene, an intermediate of medicine and optical waveguide materials, and flutamide, a non steroidal anti androgen drug.

Chemical Properties

Orange to Brown to Dark red powder to crystal.

Uses

4-Nitro-3-(trifluoromethyl)aniline is a metabolite of Flutamide (F598850) (FLU-1 or M2).

Uses

A metabolite of Flutamide (FLU-1 or M2).

Synthesis

The thiazolium salt 3 (3.30 mg, 0.0122 mmol) was added to a solution of 1-azido-4-nitrobenzene (0.122 mmol) and t-BuOH (18.0 mg, 0.244 mmol) in degassed THF (0.50 mL) under argon at r.t. The resulting suspension was stirred for 5 min, and then NaOt-Bu (23.4 mg, 0.244 mmol) was added in one portion, and the mixture was stirred (Table 2). Water (2 mL) was added, and the products were extracted with EtOAc (2 ?á 2 mL), the combined organic phase was dried over anhyd MgSO4, filtered, and concentrated in vacuo. Purification was achieved by passing the resulting residue through a short pad of silica (eluting with 50% light PE-EtOAc) unless otherwise stated.
4-Nitro-3-trifluoromethyl aniline, Time: 12 h, Pale yellow solid (21.0 mg, 84%). (70:30 petrol-EtOAc) 0.5; mp 90-93 ??C (lit., 92-93 ??C); IR (FTIR, CHCl3) |ímax cm-1: 3535 (NH2), 3434 (NH2), 1635, 1592 (NO2), 1520 (NO2), 1119; 1H NMR (400 MHz, DMSO-6) 8.59 (d, = 2.7 Hz, 1H), 8.55 (dd, = 9.3, 2.7 Hz, 1H), 7.55 (br s, 2H), 7.32 (d, = 9.3 Hz, 1H); 13C NMR (100 MHz, DMSO-6) 151.8 (C), 135.0 (C), 128.7 (CH), 123.7 (J = 5.9 Hz, F3N2NaO2 [M+Na]+, 229.0195; found, 229.0195.

Fig. The synthetic of 4-Nitro-3-trifluoromethyl aniline

4-Nitro-3-trifluoromethyl aniline Preparation Products And Raw materials

Raw materials

Preparation Products

Flutamide

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4-Nitro-3-trifluoromethyl aniline Suppliers

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View Lastest Price from 4-Nitro-3-trifluoromethyl aniline manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-NITRO-3-TRIFLUOROMETHYL ANILINE 393-11-3
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100
Release date: 2024-10-30

Guangzhou Tengyue Chemical Co., Ltd.

Product: 4-Nitro-3-trifluoromethyl aniline 393-11-3
Price: US $260.00/g
Min. Order: 50g
Purity: 99% Purity (What/sapp: +86 18145728414)
Supply Ability: 1000 Tons/Month
Release date: 2023-06-29

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Nitro-3-trifluoromethyl aniline 393-11-3
Price: US $0.00-0.00/KG
Min. Order: 50mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-08

393-11-3, 4-Nitro-3-trifluoromethyl anilineRelated Search:

Aniline 4-Nitrotoluene 4-(Trifluoromethoxy)aniline 2-Nitro-4-methylsulfonyltoluene 2-Aminobenzotrifluoride 4-NITRO-2-SULFOANILINE 2-Nitrotoluene 3-Aminobenzotrifluoride Benzotrifluoride Glycine 2-Methylbenzotrifluoride ALTRENOGEST Betaine 4'-Nitroacetanilide N-Methyl-4-nitroaniline 5-Fluoro-2-nitrotoluene 4-NITRODIAZOAMINOBENZENE 3-Fluorobenzotrifluoride

4-Nitro-3-Triflouromethyl Aniline (Flutamide Intermediate)

Flutamide ImpurityⅠ:4-Nitro-3-(trifluoromethyl)aniline

α,α,α-Trifluoro-4-nitro-m-toluidine

4-nitro-3-(trifluoromethyl)benzeneamine

Flutamide Impurity A

4-Nitro-α,α,α

4-Nitro-3-(trifluoromethyl)aniline (FLU-1)

5-Amino-2-nitrobenzotrifluoride, 4-Nitro-α,α,α-trifluoro-m-toluidine

4-nitro-3-(trifluoromethyl)benzenamine

FLU-1

4-Nitro-3-(trifluoromethyl)aniline ,98%

FlutaMide Related CoMpound A

The 4- nitro-3- threetrifluoroMethylaniline

4-Nitro-4-(trifluoromethyl)aniline

Flutamide Related Compound A (20 mg) (4-nitro-3-(trifluoromethyl)aniline)

4-Nitro-3-(trifluoromethyl)aniline 98%

2-NITRO-5-AMINO BENZOTRIFLUORIDE

5-AMINO-2-NITROBENZOTRIFLUORIDE

4-NITRO-3-(TRIFLUOROMETHYL)ANILINE

4-NITRO-ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLUIDINE

3-AMINO-6-NITROBENZOTRIFLUORIDE

TIMTEC-BB SBB006652

2-Nitro-5-aminobenzotriluoride

Benzenamine, 4-nitro-3-(trifluoromethyl)-

4-Nitro-α,α,α-trifluoro-m-toluidine

3-Trifluoromethyl-4-nitroaniline

4-Nitro-3-(trifluoromethyl) aniline (3-Amino-6-nitrobenzotrifluoride)

4-Nitro-3-aminobenzotrifluoride

4-Nitro-3-trifluoromethylaniline(Flutamide impurity)

5-Amino-2-nitrobenzotrifluoride,97%

5-Amino-2-nitrobenzotrifluoride 98%

5-Amino-2-nitrobenzotrifluoride98%

2-NITRO-5-AMINOBENZOTRIFLUORIDE(3-TRIFLUOROMETHYL-4-NITROANILINE)

3-trifluoromethyl-4-nitroanilide

4-Nitro-3-(trifluormethyl)anilin

3-trifluoromethyl-4-nitroaniune

5-Amino-2-nitrobenzotrifluoride &gt

Nilutamide impurity B CRS

Nilutamide Impurity 3

4-NITRO-3-TRIFLUOROMETHYL ANILINE CAS NO 393-11-3

Flutamide Impurity 1 (Flutamide EP Impurity A)

TIANFU-CHEM 4-Nitro-3-trifluoromethyl aniline

Flutamide Related Compound A (4-nitro-3-(trifluoromethyl)aniline) (1285997)

Flutamide USP Related Compound A

4-nitro-3-(trifluoromethyl)aniline (nifeline)

Flutamide EP Impurity A（Nilutamide EP Impurity B）

4-Nitro-3-(trifluoromethyl0aniline

Linagliptin Impurity CD10103

4-Nitro-3-trifluoromethyl aniline, 10 mM in DMSO

2-Nitro-5-Aminotrifluorotoluene

393-11-3

Organic Building Blocks

Nitrogen Compounds

Amines

Building Blocks

Anilines, Aromatic Amines and Nitro Compounds

Amines