5-Nitroquinoline

Product Name: 5-Nitroquinoline
CAS No.: 607-34-1
Chemical Name: 5-Nitroquinoline
Synonyms: AKOS 92273;5-NitroquinoL;5-Nitrochinolin;5-nitro-quinolin;5-NITROQUINOLINE;Quinoline,5-nitro-;5-Nitroquinoline>5-Nitroquinoline,99%;5-NITROQUINOLINE 98+%;5-Nitro-1-azanaphthalene
CBNumber: CB4484970
Molecular Formula: C9H6N2O2
Formula Weight: 174.16
MOL File: 607-34-1.mol

More

Less

5-Nitroquinoline Property

Melting point:: 71-73 °C (lit.)
Boiling point:: 70-73°C
Density: 1.2190 (estimate)
refractive index: 1.6820 (rough estimate)
storage temp.: Inert atmosphere,Room Temperature
Water Solubility: Slightly soluble in water
form: powder to crystal
pka: 2.80±0.12(Predicted)
color: Plates from EtOH (aq)
InChI: InChI=1S/C9H6N2O2/c12-11(13)9-5-1-4-8-7(9)3-2-6-10-8/h1-6H
InChIKey: NDDZXHOCOKCNBM-UHFFFAOYSA-N
SMILES: N1C2C(=C([N+]([O-])=O)C=CC=2)C=CC=1
CAS DataBase Reference: 607-34-1(CAS DataBase Reference)
NIST Chemistry Reference: Quinoline, 5-nitro-(607-34-1)
EPA Substance Registry System: 5-Nitroquinoline (607-34-1)

More

Less

Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-40-68-36/37/38
Safety Statements: 7-22-36-45-36/37/39-26
WGK Germany: 3
RTECS: VC1850000
Hazard Note: Irritant
HS Code: 29334900
Toxicity: mmo-sat 10 mg/plate MUREAV 92,29,82

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N23807
Product name: 5-Nitroquinoline
Purity: 99%
Packaging: 5g
Price: $83.8
Updated: 2023/06/20

TCI Chemical

Product number: N0344
Product name: 5-Nitroquinoline
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: N0344
Product name: 5-Nitroquinoline
Purity: >98.0%(GC)(T)
Packaging: 250g
Price: $225
Updated: 2025/07/31

TRC

Product number: N520148
Product name: 5-Nitroquinoline
Packaging: 250mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: J51928
Product name: 5-Nitroquinoline
Packaging: 25g
Price: $45
Updated: 2021/12/16

More

Less

5-Nitroquinoline Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Safety Profile

Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx. Seealso other nitroquinoline entries.

Synthesis

91-22-5

607-35-2

607-34-1

General procedure for the synthesis of 8-nitroquinoline and 5-nitroquinoline from quinoline: Pure sulfuric acid (H2SO4) was slowly added to 1 equivalent of quinoline at 0 °C. Subsequently, 3 equivalents of 65% nitric acid (HNO3) were added dropwise and the reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the mixture was poured sequentially into ice water, neutralized with sodium carbonate (Na2CO3) to pH neutral, and then extracted twice with dichloromethane (DCM). The organic layers were combined, washed with water, dried over anhydrous sodium sulfate (Na2SO4) and finally the solvent was evaporated under vacuum. 8-Nitroquinoline (compound 35) was obtained as a light yellow solid in 34% yield; melting point 90 °C, literature value: 89-90 °C [43].1H NMR (200 MHz, CDCl3) δ: 7.53-7.66 (m, 2H), 8.04 (d, J = 8.0 Hz, 2H), 8.27 (dd, J = 1.6 and 8.4 Hz, 1H). 9.70 (dd, J = 1.7 and 4.2 Hz, 1H). 13C NMR (50 MHz, CDCl3) δ: 122.8 (CH), 123.8 (CH), 125.3 (CH), 129.0 (C), 132.0 (CH), 136.1 (CH), 139.5 (C), 148.2 (C), 152.6 (CH ). Recrystallization by isopropanol afforded 5-nitroquinoline (compound 36) as a light yellow solid in 38% yield; melting point 71 °C, literature value: 71-72 °C [41].1H NMR (200 MHz, CDCl3) δ: 7.61-7.68 (m, 1H), 7.76-7.85 (m, 1H), 8.36-8.45 (m, 2H). 8.98-9.04 (m, 2H).13C NMR (50MHz, CDCl3) δ: 121.2 (C), 123.9 (CH), 124.6 (CH), 127.5 (CH), 131.9 (CH), 136.6 (CH), 145.5 (C), 148.2 (C), 151.6 (C).

Purification Methods

Crystallise 5-nitroquinoline from pentane, then from *benzene. The hydrochloride has m 224o and the picrate has m 206o, 214o(from MeOH). [Beilstein 20 H 371, 20 II 235, 20 III/IV 3397.]

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 54, p. 75 - 86
[2] European Journal of Medicinal Chemistry, 2018, vol. 155, p. 135 - 152
[3] Journal of the Chemical Society, 1892, vol. 61, p. 788
[4] Chemische Berichte, 1885, vol. 18, p. 1243
[5] Journal fuer Praktische Chemie (Leipzig), 1896, vol. <2> 53, p. 392

5-Nitroquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

5-Hydroxyquinoline

More

Less

5-Nitroquinoline Suppliers

Americas 1 Austria 1 Belgium 2 China 184 Europe 4 Germany 5 India 14 Japan 5 Poland 1 Slovakia 1 Switzerland 3 The Netherlands 1 Ukraine 2 United Kingdom 18 United States 31 Global 273

SiChuang NanBu Honesty Technology Co., Ltd.

Tel: 0838-5675166 15883665058
Fax: 0838-5675535
Email: nbcxkj@126.com
Country: China
ProdList: 918
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1995
Advantage: 65

TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
Fax: +86 351 7031519
Email: sales@RHFChem.com
Country: China
ProdList: 2338
Advantage: 56

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing dtftchem Technology Co., Ltd.

Tel: 010-60275820 13031183356
Fax: 010-60270825
Email: elainezt@sina.com
Country: China
ProdList: 1390
Advantage: 62

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

More

Less

View Lastest Price from 5-Nitroquinoline manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 5-Nitroquinoline 607-34-1
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-25

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Nitroquinoline 607-34-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-12

Shanghai Rlavie Technology Co ltd

Product: 5-Nitroquinoline 607-34-1
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2022-01-03

607-34-1, 5-NitroquinolineRelated Search:

Ethoxyquin 6-Hydroxy-2(1H)-3,4-dihydroquinolinone Quinhydrone 8-Hydroxyquinoline 4-methylquinoline quinolinium hydrogen sulphate Isoquinoline Quinclorac 6-METHYL-5-NITROQUINOLINE 5-nitrobenzofuran 5-NITRO-1,10-PHENANTHROLINE-2,9-DICARBOXYLIC ACID 5-Nitro-1,10-phenanthroline 8-chloro-5-nitro-quinoline 6-BROMO-5-NITROQUINOLINE 7-METHYL-8-NITROQUINOLINE 1,2,3,4-TETRAHYDRO-7-NITROQUINOLINE 5-Amino-6-nitroquinoline Nitroxoline

5-nitro-quinolin

Quinoline,5-nitro-

5-NITROQUINOLINE

AKOS 92273

5-Nitroquinoline,99%

5-Nitrochinolin

5-NITROQUINOLINE 98+%

5-Nitro-1-azanaphthalene

5-Nitroquinoline≥ 98% (TLC)

5-Nitroquinoline&gt

5-NitroquinoL

5-Nitroquinoline ISO 9001：2015 REACH

607-34-1

O2NC9H5NCH3

Quinolines

Nitroquinolines

Building Blocks

Heterocyclic Building Blocks

Quinolines, Quinazolines and derivatives

Building Blocks

C8 to C10

Chemical Synthesis

Heterocyclic Building Blocks

Heterocycles

Quinoline&Isoquinoline

Quinolines

Nitroquinolines

Building Blocks

Heterocyclic Building Blocks