ChemicalBook > CAS DataBase List > BRL 50481

BRL 50481

Product Name
BRL 50481
CAS No.
433695-36-4
Chemical Name
BRL 50481
Synonyms
-50481;BRL 50481;BRL-50481, Selective PDE7 inhibitor;5-NITRO-2,N,N-TRIMETHYLBENZENESULFONAMIDE;N,N,2-TRIMETHYL-5-NITRO-BENZENESULFONAMIDE;Benzenesulfonamide, N,N,2-trimethyl-5-nitro-;3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene,5-Nitro-2-N,N-trimethylbenzenesulfonamide
CBNumber
CB4485083
Molecular Formula
C9H12N2O4S
Formula Weight
244.27
MOL File
433695-36-4.mol
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BRL 50481 Property

Melting point:
65-67°C
Boiling point:
391.1±52.0 °C(Predicted)
Density 
1.334±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 12 mg/mL
form 
solid
pka
-5?+-.0.70(Predicted)
color 
white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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Safety

WGK Germany 
3
HS Code 
2935.90.9500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B0936
Product name
BRL 50481
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$195
Updated
2024/03/01
Sigma-Aldrich
Product number
B0936
Product name
BRL 50481
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$610
Updated
2024/03/01
TCI Chemical
Product number
T3112
Product name
N,N,2-Trimethyl-5-nitrobenzenesulfonamide
Purity
>98.0%(HPLC)(N)
Packaging
200mg
Price
$44
Updated
2024/03/01
TCI Chemical
Product number
T3112
Product name
N,N,2-Trimethyl-5-nitrobenzenesulfonamide
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$130
Updated
2024/03/01
Alfa Aesar
Product number
J67146
Product name
BRL-50481, 98%
Packaging
10mg
Price
$122
Updated
2021/12/16
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BRL 50481 Chemical Properties,Usage,Production

Description

BRL-50481 (433695-36-4) is a potent and selective inhibitor of phosphodiesterase-7 (PDE7), Ki=180 nM.1?Induces apoptosis in chronic lymphocytic leukemia cells which express PDE7B.2?BRL-50481 increases mineralization in osteoblasts differentiated from hMSC.3?Cell permeable.

Chemical Properties

Off-White Solid

Uses

A PDE7 inhibitor that has acceptable selectivity for in vivo studies

Definition

ChEBI: BRL-50481 is a C-nitro compound that is benzene substituted by N,N-dimethylaminosulfonyl, methyl and nitro groups at positions 1, 2 and 5, respectively. It is a phosphodiesterase inhibitor selective for the PDE7 subtype (Ki = 180 nM). It has a role as an EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor, a geroprotector and a bone density conservation agent. It is a sulfonamide, a C-nitro compound and a member of toluenes.

Biological Activity

Selective, substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (K i = 180 nM). Displays > 200-fold selectivity over PDE1B, PDE1C, PDE2, PDE3, PDE4A4 and PDE5.

Biochem/physiol Actions

BRL 50481 is a potent and selective PDE7 inhibitor (IC50 = 260 nM).

storage

Store at +4°C

References

1) Smith et al. (2004), Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages and CD8+ T-lymphocytes; Mol. Pharmacol., 66 1679 2) Zhang et al. (2008), Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia; Proc. Natl. Acad. Sci. USA 105 19532 3) Pekkinen et al. (2008), Effects of phosphodiesterase 7 inhibition by RNA interference on the gene expression and differentiation of human mesenchymal stem cell-derived osteoblasts; Bone 43 84

BRL 50481 Preparation Products And Raw materials

Raw materials

Preparation Products

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BRL 50481 Suppliers

Canada 1 China 72 Germany 2 India 2 Japan 1 Switzerland 1 United Kingdom 3 United States 18 Global 100
J & K SCIENTIFIC LTD.
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View Lastest Price from BRL 50481 manufacturers

Career Henan Chemical Co
Product
BRL 50481 433695-36-4
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

433695-36-4, BRL 50481Related Search:

ZARDAVERINE RO 20-1724 S- (+)-Rolipram ETAZOLATE Vinpocetine ZAPRINAST ROLIPRAM Cilostazol (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE CILOSTAMIDE EHNA HYDROCHLORIDE 4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE BRL 50481 1-(2-METHYL-5-NITRO-BENZENESULFONYL)-PIPERIDINE-4-CARBOXYLIC ACID 1-[(2-METHYL-5-NITROPHENYL)SULFONYL]PIPERIDINE-2-CARBOXYLIC ACID TIMTEC-BB SBB001165 4-[4-[(2-METHYL-5-NITROPHENYL)SULFONYL]PIPERAZIN-1-YL]-4-OXOBUTANOIC ACID 1-[(2-METHYL-5-NITROPHENYL)SULFONYL]PIPERAZINE

  • 5-NITRO-2,N,N-TRIMETHYLBENZENESULFONAMIDE
  • BRL 50481
  • N,N,2-TRIMETHYL-5-NITRO-BENZENESULFONAMIDE
  • 3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene,5-Nitro-2-N,N-trimethylbenzenesulfonamide
  • Benzenesulfonamide, N,N,2-trimethyl-5-nitro-
  • -50481
  • BRL-50481, Selective PDE7 inhibitor
  • 433695-36-4
  • Phosphodiesterase 7
  • P to Q
  • Enzyme Inhibitors
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme
  • BioChemical
  • Biochemicals and Reagents
  • All Inhibitors
  • Inhibitors
  • Cyclic Nucleotide related