BRL 50481
- Product Name
- BRL 50481
- CAS No.
- 433695-36-4
- Chemical Name
- BRL 50481
- Synonyms
- -50481;BRL 50481;BRL-50481 ，S5837;BRL-50481 (BRL50481;BRL-50481, Selective PDE7 inhibitor;5-NITRO-2,N,N-TRIMETHYLBENZENESULFONAMIDE;N,N,2-TRIMETHYL-5-NITRO-BENZENESULFONAMIDE;Benzenesulfonamide, N,N,2-trimethyl-5-nitro-;3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene,5-Nitro-2-N,N-trimethylbenzenesulfonamide
- CBNumber
- CB4485083
- Molecular Formula
- C9H12N2O4S
- Formula Weight
- 244.27
- MOL File
- 433695-36-4.mol
BRL 50481 Property
- Melting point:
- 65-67°C
- Boiling point:
- 391.1±52.0 °C(Predicted)
- Density
- 1.334±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 12 mg/mL
- form
- solid
- pka
- -5?+-.0.70(Predicted)
- color
- white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety
- WGK Germany
- 3
- HS Code
- 2935.90.9500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B0936
- Product name
- BRL 50481
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $189.6
- Updated
- 2025/07/31
- Product number
- B0936
- Product name
- BRL 50481
- Purity
- ≥98% (HPLC), solid
- Packaging
- 25mg
- Price
- $596
- Updated
- 2025/07/31
- Product number
- T3112
- Product name
- N,N,2-Trimethyl-5-nitrobenzenesulfonamide
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 200mg
- Price
- $40
- Updated
- 2025/07/31
- Product number
- T3112
- Product name
- N,N,2-Trimethyl-5-nitrobenzenesulfonamide
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 1g
- Price
- $117
- Updated
- 2025/07/31
- Product number
- 16899
- Product name
- BRL 50481
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $44
- Updated
- 2024/03/01
BRL 50481 Chemical Properties,Usage,Production
Description
BRL-50481 (433695-36-4) is a potent and selective inhibitor of phosphodiesterase-7 (PDE7), Ki=180 nM.1?Induces apoptosis in chronic lymphocytic leukemia cells which express PDE7B.2?BRL-50481 increases mineralization in osteoblasts differentiated from hMSC.3?Cell permeable.
Chemical Properties
Off-White Solid
Uses
A PDE7 inhibitor that has acceptable selectivity for in vivo studies
Definition
ChEBI: BRL-50481 is a C-nitro compound that is benzene substituted by N,N-dimethylaminosulfonyl, methyl and nitro groups at positions 1, 2 and 5, respectively. It is a phosphodiesterase inhibitor selective for the PDE7 subtype (Ki = 180 nM). It has a role as an EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor, a geroprotector and a bone density conservation agent. It is a sulfonamide, a C-nitro compound and a member of toluenes.
Biological Activity
Selective, substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (K i = 180 nM). Displays > 200-fold selectivity over PDE1B, PDE1C, PDE2, PDE3, PDE4A4 and PDE5.
Biochem/physiol Actions
BRL 50481 is a potent and selective PDE7 inhibitor (IC50 = 260 nM).
storage
Store at +4°C
References
[1] SUSAN J SMITH. Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes.[J]. Molecular Pharmacology, 2004, 66 6: 1679-1689. DOI:10.1124/mol.104.002246
[2] LINGZHI ZHANG. Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2008: 19532-19537. DOI:10.1073/pnas.0806152105
[3] MINNA PEKKINEN . Effects of phosphodiesterase 7 inhibition by RNA interference on the gene expression and differentiation of human mesenchymal stem cell-derived osteoblasts[J]. Bone, 2008, 43 1: Pages 84-91. DOI:10.1016/j.bone.2008.02.021
BRL 50481 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BRL 50481 manufacturers
- Product
- BRL 50481 433695-36-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26