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Thionicotinamide

Product Name
Thionicotinamide
CAS No.
4621-66-3
Chemical Name
Thionicotinamide
Synonyms
AKOS B028584;THIONICOTINAMIDE;thio-nicotinamid;Nicotinthioamide;nicotinothioamide;Nicotinamide, thio-;3-thioamidopyridine;ART-CHEM-BB B028584;PYRIDINE-3-THIOAMIDE;Thionicotinamide,98%
CBNumber
CB4489258
Molecular Formula
C6H6N2S
Formula Weight
138.19
MOL File
4621-66-3.mol
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Thionicotinamide Property

Melting point:
185-190 °C
Boiling point:
278.9±32.0 °C(Predicted)
Density 
1.235 (estimate)
refractive index 
1.5300 (estimate)
Flash point:
160 °C
storage temp. 
Inert atmosphere,Room Temperature
pka
12.01±0.29(Predicted)
form 
Powder
color 
Yellow to yellow-green
BRN 
109593
InChI
InChI=1S/C6H6N2S/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
InChIKey
XQWBMZWDJAZPPX-UHFFFAOYSA-N
SMILES
C1=NC=CC=C1C(N)=S
LogP
0.670
CAS DataBase Reference
4621-66-3(CAS DataBase Reference)
EPA Substance Registry System
3-Pyridinecarbothioamide (4621-66-3)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
24/25-36-26
RTECS 
QS4488000
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
T0765
Product name
Thionicotinamide
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$56
Updated
2024/03/01
Alfa Aesar
Product number
A11144
Product name
Thionicotinamide, 98%
Packaging
25g
Price
$33.4
Updated
2021/12/16
Alfa Aesar
Product number
A11144
Product name
Thionicotinamide, 98%
Packaging
100g
Price
$103
Updated
2021/12/16
TRC
Product number
T367758
Product name
Thionicotinamide
Packaging
1g
Price
$45
Updated
2021/12/16
TRC
Product number
T367758
Product name
Thionicotinamide
Packaging
10g
Price
$75
Updated
2021/12/16
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Thionicotinamide Chemical Properties,Usage,Production

Chemical Properties

yellow powder

Definition

Thionicotinamide is the active moiety of two previously identified NADK inhibitors, NADS and NADPS. Treatment of C85 cancer cells with thionicotinamide resulted in an identical loss of dihydrofolate reductase levels, a G1/S block, and similar toxicity profiles as NADS and NADPS; that is, thionicotinamide is a prodrug and is converted intracellularly to NADPS[1].

References

[1] Philip M Tedeschi. “Suppression of Cytosolic NADPH Pool by Thionicotinamide Increases Oxidative Stress and Synergizes with Chemotherapy.” Molecular Pharmacology 88 4 (2015): 720–7.

Thionicotinamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Thionicotinamide Suppliers

Austria 1 Belgium 3 China 143 Europe 1 France 1 Germany 9 India 10 Japan 3 Russia 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 11 United States 35 Global 222
Chemspon Bio-Tech Co., Ltd
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View Lastest Price from Thionicotinamide manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
THIONICOTINAMIDE 4621-66-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-06
Shaanxi Dideu Medichem Co. Ltd
Product
Thionicotinamide 4621-66-3
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2024-08-08
Hebei Zhanyao Biotechnology Co. Ltd
Product
Thionicotinamide 4621-66-3
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-19

4621-66-3, ThionicotinamideRelated Search:

6-METHOXYPYRIDINE-3-CARBOTHIOAMIDE Thionicotinamide adenine dinucleotide THIONICOTINAMIDE Nicotinamide 6-(2,2,2-TRIFLUOROETHOXY)PYRIDINE-3-THIOCARBOXAMIDE 6-(TRIFLUOROMETHYL)THIONICOTINAMIDE QUINOLINE-4-CARBOXYLIC ACID HYDRAZIDE ADENOSINE 5'-(TRIHYDROGEN DIPHOSATE), 2'-(SODIUM HYDROGEN PHOSPHATE), P',5'-ESTER WITH 3-(AMINOTHIOXOMETHYL)-1-BETA-D-RIBOFURANOSYLPYRIDIUM INNER SALT 6-METHYLPYRIDINE-3-CARBOTHIOAMIDE 4-(TRIFLUOROMETHYL)PYRIDINE-3-THIOCARBOXAMIDE 3-THIONICOTINAMIDE-N-OXIDE 6-(TRIFLUOROMETHYL)THIONICOTINAMIDE Rocastine 6-(1H-1,2,4-triazol-1-yl)pyridine-3-carbothioamide BUTTPARK 115\40-30 2-pyrrolidin-1-ylpyridine-3-carbothioamide 6-(4-CHLOROPHENOXY)PYRIDINE-3-CARBOTHIOAMIDE ETHYL 5-(AMINOCARBOTHIOYL)-6-METHYL-2-(TRIFLUOROMETHYL)NICOTINATE

  • THIONICOTINAMIDE
  • PYRIDINE-3-CARBOTHIOAMIDE
  • PYRIDINE-3-CARBOTHIOIC ACID AMIDE
  • PYRIDINE-3-THIOAMIDE
  • 3-pyridinecarbothioamide
  • 3-pyridinethiocarboxamide
  • 3-pyridylthioformamide
  • 3-thioamidopyridine
  • ThionicotinaMide, 99% 25GR
  • Amino-3-pyridylmethane-1-thione
  • Nicotinamide, thio-
  • 3-thiocarbamoylpyridine
  • nicotinothioamide
  • thio-3-pyridinecarboxamide
  • thio-nicotinamid
  • ART-CHEM-BB B028584
  • AKOS B028584
  • 3-PYRIDYLTHIOCARBOXAMIDE
  • Pyridine-3-thiocarboxamide
  • Thionicotinamide,98%
  • PYRIDINE-3-THIOCARBOXAMIDE (THIONICOTINAMIDE)
  • Nicotinthioamide
  • Thionicotinamide,99%
  • pyridin-3-ylthioamide
  • Thionicotinamide &gt
  • Pyriding-3-carbothioamide
  • Nicotinamide Impurity 89
  • 4621-66-3