Thionicotinamide

Product Name: Thionicotinamide
CAS No.: 4621-66-3
Chemical Name: Thionicotinamide
Synonyms: AKOS B028584;THIONICOTINAMIDE;thio-nicotinamid;Nicotinthioamide;nicotinothioamide;Nicotinamide, thio-;3-thioamidopyridine;ART-CHEM-BB B028584;PYRIDINE-3-THIOAMIDE;Thionicotinamide,98%
CBNumber: CB4489258
Molecular Formula: C6H6N2S
Formula Weight: 138.19
MOL File: 4621-66-3.mol

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Thionicotinamide Property

Melting point:: 185-190 °C
Boiling point:: 278.9±32.0 °C(Predicted)
Density: 1.235 (estimate)
refractive index: 1.5300 (estimate)
Flash point:: 160 °C
storage temp.: Inert atmosphere,Room Temperature
pka: 12.01±0.29(Predicted)
form: Powder
color: Yellow to yellow-green
BRN: 109593
InChI: InChI=1S/C6H6N2S/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
InChIKey: XQWBMZWDJAZPPX-UHFFFAOYSA-N
SMILES: C1=NC=CC=C1C(N)=S
LogP: 0.670
CAS DataBase Reference: 4621-66-3(CAS DataBase Reference)
EPA Substance Registry System: 3-Pyridinecarbothioamide (4621-66-3)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 24/25-36-26
RTECS: QS4488000
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: T0765
Product name: Thionicotinamide
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $56
Updated: 2024/03/01

Alfa Aesar

Product number: A11144
Product name: Thionicotinamide, 98%
Packaging: 25g
Price: $33.4
Updated: 2021/12/16

Alfa Aesar

Product number: A11144
Product name: Thionicotinamide, 98%
Packaging: 100g
Price: $103
Updated: 2021/12/16

TRC

Product number: T367758
Product name: Thionicotinamide
Packaging: 1g
Price: $45
Updated: 2021/12/16

TRC

Product number: T367758
Product name: Thionicotinamide
Packaging: 10g
Price: $75
Updated: 2021/12/16

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Thionicotinamide Chemical Properties,Usage,Production

Chemical Properties

yellow powder

Definition

Thionicotinamide is the active moiety of two previously identified NADK inhibitors, NADS and NADPS. Treatment of C85 cancer cells with thionicotinamide resulted in an identical loss of dihydrofolate reductase levels, a G1/S block, and similar toxicity profiles as NADS and NADPS; that is, thionicotinamide is a prodrug and is converted intracellularly to NADPS[1].

References

[1] Philip M Tedeschi. “Suppression of Cytosolic NADPH Pool by Thionicotinamide Increases Oxidative Stress and Synergizes with Chemotherapy.” Molecular Pharmacology 88 4 (2015): 720–7.

Thionicotinamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Thionicotinamide Suppliers

Austria 1 Belgium 3 China 143 Europe 1 France 1 Germany 9 India 10 Japan 3 Russia 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 11 United States 35 Global 222

Alfa Aesar, Thermo Fisher Scientific

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Email: es@alfa.com
Country: Germany
ProdList: 5123
Advantage: 58

CHEMOS GmbH & Co. KG

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Email: chemos@chemos.de
Country: Germany
ProdList: 6727
Advantage: 58

Aaron Chemistry GmbH

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Email: sales@aaron-chemistry.de
Country: Germany
ProdList: 579
Advantage: 60

AppliChem GmbH

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Email: service@applichem.de
Country: Germany
ProdList: 968
Advantage: 65

ABCR GmbH & CO. KG

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Email: info@abcr.de
Country: Germany
ProdList: 6831
Advantage: 75

Aaron Chemistry GmbH

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Country: Germany
ProdList: 137
Advantage: 34

Service Chemical Inc.

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Email: sales@chemos-group.com
Country: Germany
ProdList: 6350
Advantage: 71

AKos Consulting & Solutions GmbH

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Email: akos@akosgmbh.de
Country: Germany
ProdList: 6717
Advantage: 72

ChemCollect GmbH

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Email: contact@chemcollect.de
Country: Germany
ProdList: 6214
Advantage: 54

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View Lastest Price from Thionicotinamide manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: THIONICOTINAMIDE 4621-66-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-06

Shaanxi Dideu Medichem Co. Ltd

Product: Thionicotinamide 4621-66-3
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2024-08-08

Hebei Zhanyao Biotechnology Co. Ltd

Product: Thionicotinamide 4621-66-3
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-10-19

4621-66-3, ThionicotinamideRelated Search:

6-METHOXYPYRIDINE-3-CARBOTHIOAMIDE Thionicotinamide adenine dinucleotide THIONICOTINAMIDE Nicotinamide 6-(2,2,2-TRIFLUOROETHOXY)PYRIDINE-3-THIOCARBOXAMIDE 6-(TRIFLUOROMETHYL)THIONICOTINAMIDE QUINOLINE-4-CARBOXYLIC ACID HYDRAZIDE ADENOSINE 5'-(TRIHYDROGEN DIPHOSATE), 2'-(SODIUM HYDROGEN PHOSPHATE), P',5'-ESTER WITH 3-(AMINOTHIOXOMETHYL)-1-BETA-D-RIBOFURANOSYLPYRIDIUM INNER SALT 6-METHYLPYRIDINE-3-CARBOTHIOAMIDE 4-(TRIFLUOROMETHYL)PYRIDINE-3-THIOCARBOXAMIDE 3-THIONICOTINAMIDE-N-OXIDE 6-(TRIFLUOROMETHYL)THIONICOTINAMIDE Rocastine 6-(1H-1,2,4-triazol-1-yl)pyridine-3-carbothioamide BUTTPARK 115\40-30 2-pyrrolidin-1-ylpyridine-3-carbothioamide 6-(4-CHLOROPHENOXY)PYRIDINE-3-CARBOTHIOAMIDE ETHYL 5-(AMINOCARBOTHIOYL)-6-METHYL-2-(TRIFLUOROMETHYL)NICOTINATE

THIONICOTINAMIDE

PYRIDINE-3-CARBOTHIOAMIDE

PYRIDINE-3-CARBOTHIOIC ACID AMIDE

PYRIDINE-3-THIOAMIDE

3-pyridinecarbothioamide

3-pyridinethiocarboxamide

3-pyridylthioformamide

3-thioamidopyridine

ThionicotinaMide, 99% 25GR

Amino-3-pyridylmethane-1-thione

Nicotinamide, thio-

3-thiocarbamoylpyridine

nicotinothioamide

thio-3-pyridinecarboxamide

thio-nicotinamid

ART-CHEM-BB B028584

AKOS B028584

3-PYRIDYLTHIOCARBOXAMIDE

Pyridine-3-thiocarboxamide

Thionicotinamide,98%

PYRIDINE-3-THIOCARBOXAMIDE (THIONICOTINAMIDE)

Nicotinthioamide

Thionicotinamide,99%

pyridin-3-ylthioamide

Thionicotinamide &gt

Pyriding-3-carbothioamide

Nicotinamide Impurity 89

4621-66-3