Thionicotinamide
- Product Name
- Thionicotinamide
- CAS No.
- 4621-66-3
- Chemical Name
- Thionicotinamide
- Synonyms
- AKOS B028584;THIONICOTINAMIDE;thio-nicotinamid;Nicotinthioamide;nicotinothioamide;Nicotinamide, thio-;3-thioamidopyridine;ART-CHEM-BB B028584;PYRIDINE-3-THIOAMIDE;Thionicotinamide,98%
- CBNumber
- CB4489258
- Molecular Formula
- C6H6N2S
- Formula Weight
- 138.19
- MOL File
- 4621-66-3.mol
Thionicotinamide Property
- Melting point:
- 185-190 °C
- Boiling point:
- 278.9±32.0 °C(Predicted)
- Density
- 1.235 (estimate)
- refractive index
- 1.5300 (estimate)
- Flash point:
- 160 °C
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 12.01±0.29(Predicted)
- form
- Powder
- color
- Yellow to yellow-green
- BRN
- 109593
- InChI
- InChI=1S/C6H6N2S/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
- InChIKey
- XQWBMZWDJAZPPX-UHFFFAOYSA-N
- SMILES
- C1=NC=CC=C1C(N)=S
- LogP
- 0.670
- CAS DataBase Reference
- 4621-66-3(CAS DataBase Reference)
- EPA Substance Registry System
- 3-Pyridinecarbothioamide (4621-66-3)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 24/25-36-26
- RTECS
- QS4488000
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T0765
- Product name
- Thionicotinamide
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $56
- Updated
- 2024/03/01
- Product number
- A11144
- Product name
- Thionicotinamide, 98%
- Packaging
- 25g
- Price
- $33.4
- Updated
- 2021/12/16
- Product number
- A11144
- Product name
- Thionicotinamide, 98%
- Packaging
- 100g
- Price
- $103
- Updated
- 2021/12/16
- Product number
- T367758
- Product name
- Thionicotinamide
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- T367758
- Product name
- Thionicotinamide
- Packaging
- 10g
- Price
- $75
- Updated
- 2021/12/16
Thionicotinamide Chemical Properties,Usage,Production
Chemical Properties
yellow powder
Definition
Thionicotinamide is the active moiety of two previously identified NADK inhibitors, NADS and NADPS. Treatment of C85 cancer cells with thionicotinamide resulted in an identical loss of dihydrofolate reductase levels, a G1/S block, and similar toxicity profiles as NADS and NADPS; that is, thionicotinamide is a prodrug and is converted intracellularly to NADPS[1].
References
[1] Philip M Tedeschi. “Suppression of Cytosolic NADPH Pool by Thionicotinamide Increases Oxidative Stress and Synergizes with Chemotherapy.” Molecular Pharmacology 88 4 (2015): 720–7.
Thionicotinamide Preparation Products And Raw materials
Raw materials
Preparation Products
Thionicotinamide Suppliers
- Tel
- --
- Fax
- --
- art-chem@art-chem.com
- Country
- Russia
- ProdList
- 6560
- Advantage
- 30
View Lastest Price from Thionicotinamide manufacturers
- Product
- THIONICOTINAMIDE 4621-66-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-06
- Product
- Thionicotinamide 4621-66-3
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-08-08
- Product
- Thionicotinamide 4621-66-3
- Price
- US $10.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-19