Ibandronic acid

Product Name: Ibandronic acid
CAS No.: 114084-78-5
Chemical Name: Ibandronic acid
Synonyms: Ibandronic;BPH 24;Ibadronic Acid;Ibandronic acid;Ibandronate Acid;IBANDRONIC ACID-D3;Tirofiban Impurity 67;Ibandronic acid USP/EP/BP;Ibandronic Acid (Ibandronate);[1-Hydroxy-3-(MethylpentylaMino)propylidene]diphosphonic Acid
CBNumber: CB4500836
Molecular Formula: C9H23NO7P2
Formula Weight: 319.23
MOL File: 114084-78-5.mol

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Ibandronic acid Property

Melting point:: 113-115°C
Boiling point:: 587.8±60.0 °C(Predicted)
Density: 1.449±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Aqueous Base (Slightly), Methanol (Slightly), Water (Slightly)
pka: 1.60±0.10(Predicted)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
CAS DataBase Reference: 114084-78-5(CAS DataBase Reference)
EPA Substance Registry System: Phosphonic acid, P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis- (114084-78-5)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: I120000
Product name: IbandronicAcid
Packaging: 25mg
Price: $80
Updated: 2021/12/16

Usbiological

Product number: I0425
Product name: Ibandronic Acid
Packaging: 100mg
Price: $403
Updated: 2021/12/16

Usbiological

Product number: 014694
Product name: Ibandronic Acid-d3
Packaging: 2.5mg
Price: $425
Updated: 2021/12/16

Matrix Scientific

Product number: 100579
Product name: (1-Hydroxy-3-(methyl(pentyl)amino)propane-1,1-diyl)diphosphonic acid
Purity: 95+%
Packaging: 250mg
Price: $189
Updated: 2021/12/16

AK Scientific

Product number: G724
Product name: Ibandronicacid
Packaging: 5g
Price: $390
Updated: 2021/12/16

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Ibandronic acid Chemical Properties,Usage,Production

Description

This third generation biphosphonate was launched in Austria and Germany for the treatment of bone disorders such as hypercalcemia in malignancy and ostedysis, Paget's disease and osteoporosis. It does not effect bone mineralization, therefore, the potential risk of osteomalacia is prevented. This was a problem with first generation derivatives. While the exact mode of action is not understood, they are inhibitors of osteroclast mediated bone resorption. These compounds strongly interact with hydroxyapatite crystals and have a half-life in the skeleton of several years. Despite this observation ibandronate was well tolerated and safe.

Chemical Properties

White Solid

Originator

Boehringer Mannheim (Germany)

Uses

Labelled Ibandronic Acid (I120000). A bisphosphonate antiresorptive agent. Bone resorption inhibitor.

Uses

A bisphosphonate antiresorptive agent. Bone resorption inhibitor.

Uses

A biphosphonate bone resorption inhibitor.

Uses

A labeled biphosphonate bone resorption inhibitor.

brand name

Bondronat

Clinical Use

Bisphosphonate:

Reduction of bone damage in bone metastases in breast cancer

Hypercalcaemia of malignancy

Postmenopausal osteoporosis

Metabolism

After initial systemic exposure, ibandronic acid rapidly binds to bone or is excreted into urine. There is no evidence that ibandronic acid is metabolised in animals or humans. The absorbed fraction of ibandronic acid is removed from the circulation via bone absorption (estimated to be 40-50% in postmenopausal women) and the remainder is eliminated unchanged by the kidney. The unabsorbed fraction of ibandronic acid is eliminated unchanged in the faeces. Renal clearance accounts for 50-60% of total clearance and is related to creatinine clearance. The difference between the apparent total and renal clearances is considered to reflect the uptake by bone.

Ibandronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Ibandronic acid Suppliers

Canada 3 China 110 Europe 1 India 11 United Kingdom 3 United States 19 Global 147

LGM Pharma

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Combi-Blocks Inc.

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Matrix Scientific

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Medical Isotopes

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APAC Pharmaceutical, LLC

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SynFine Research

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View Lastest Price from Ibandronic acid manufacturers

Sinoway Industrial co., ltd.

Product: Ibandronic Acid 114084-78-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20TONS
Release date: 2024-09-03

Hebei Zhanyao Biotechnology Co. Ltd

Product: Ibandronic acid 114084-78-5
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-11-02

Dideu Industries Group Limited

Product: Ibandronic acid 114084-78-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-28

114084-78-5, Ibandronic acidRelated Search:

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{1-Hydroxy-3-(methylpentylamino)propylidene]bisphosphnic Acid

[1-Hydroxy-3-(methyl-d3-pentylamino)propylidene]bisphosphnic Acid

Ibandronic

IBANDRONIC ACID-D3

1-Hydroxy-3-(methylpentylamino)propylidene bisphosphonic acid

Ibandronic acid

P,P'-[1-Hydroxy-3-(methylpentylamino)propylidene]bisphosphonic Acid

Ibadronic Acid

Ibandronate Acid

[1-Hydroxy-3-(MethylpentylaMino)propylidene]diphosphonic Acid

BPH 24

(1-Hydroxy-3-(Methyl(pentyl)aMino)propane-1,1-diyl)diphosphonic acid

Phosphonic acid, P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis-

Ibandronic acid USP/EP/BP

IbandronateQ: What is Ibandronate Q: What is the CAS Number of Ibandronate Q: What is the storage condition of Ibandronate Q: What are the applications of Ibandronate

Tirofiban Impurity 67

Ibandronic Acid (Ibandronate)

114084-78-5

14084-78-5

C9H20D3NO7P2

C9H23NO7P2

C9H25O7NP2

C9H20NO7P2D3

Phosphorylating and Phosphitylating Agents

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Isotope Labeled Compounds

anti-osteoporosis